Bistable biological regulatory systems need to cope with stochastic noise to fine tune their function close to bifurcation points. Here, we study stability properties of this regime in generic systems to demonstrate that cooperative interactions buffer system variability, hampering noise-induced regime shifts. Our analysis also shows that, in the considered cooperativity range, impending regime shifts can be generically detected by statistical early warning signals from distributional data. Our generic framework, based on minimal models, can be used to extract robustness and variability properties of more complex models and empirical data close to criticality.

Buffering variability in cell regulation motifs close to criticality / Proverbio, Daniele; Montanari, Arthur N.; Skupin, Alexander; Gonsalves, Jorge. - In: PHYSICAL REVIEW. E. - ISSN 2470-0045. - 106:3(2022). [10.1103/PhysRevE.106.L032402]

Buffering variability in cell regulation motifs close to criticality

Proverbio, Daniele
Primo
;
2022-01-01

Abstract

Bistable biological regulatory systems need to cope with stochastic noise to fine tune their function close to bifurcation points. Here, we study stability properties of this regime in generic systems to demonstrate that cooperative interactions buffer system variability, hampering noise-induced regime shifts. Our analysis also shows that, in the considered cooperativity range, impending regime shifts can be generically detected by statistical early warning signals from distributional data. Our generic framework, based on minimal models, can be used to extract robustness and variability properties of more complex models and empirical data close to criticality.
2022
3
Proverbio, Daniele; Montanari, Arthur N.; Skupin, Alexander; Gonsalves, Jorge
Buffering variability in cell regulation motifs close to criticality / Proverbio, Daniele; Montanari, Arthur N.; Skupin, Alexander; Gonsalves, Jorge. - In: PHYSICAL REVIEW. E. - ISSN 2470-0045. - 106:3(2022). [10.1103/PhysRevE.106.L032402]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/397189
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