Background: Households are an important location for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, especially during periods when travel and work was restricted to essential services. We aimed to assess the association of close-range contact patterns with SARS-CoV2 transmission.Methods: We deployed proximity sensors for two weeks to measure face-to- face interactions between household members after SARS-CoV- 2 was identified in the household, in South Africa, 2020-2021. We calculated the duration, frequency, and average duration of close-range proximity events with SARS-CoV-2 index cases. We assessed the association of contact parameters with SARS-CoV2 transmission using mixed effects logistic regression accounting for index and household member characteristics.Results: We included 340 individuals (88 SARS-CoV- 2 index cases and 252 household members). On multivariable analysis, factors associated with SARS-CoV- 2 acquisition were index cases with minimum Ct value <30 (aOR 16.8 95% CI 3.1-93.1) vs >35, and female contacts (aOR 2.5 95% CI 1.3-5.0). No contact parameters were associated with acquisition (aOR 1.0-1.1) for any of the duration, frequency, cumulative time in contact, or average duration parameters.Conclusions: We did not find an association between close-range proximity events and SARS-CoV-2 household transmission. Our findings may be due to study limitations, that droplet-mediated transmission during close-proximity contacts plays a smaller role than airborne transmission of SARS-CoV-2 in the household, or due to high contact rates in households.

Association of close-range contact patterns with SARS-CoV-2: a household transmission study / Kleynhans, Jackie; Dall'Amico, Lorenzo; Gauvin, Laetitia; Tizzoni, Michele; Maloma, Lucia; Walaza, Sibongile; Martinson, Neil A; von Gottberg, Anne; Wolter, Nicole; Makhasi, Mvuyo; Cohen, Cheryl; Cattuto, Ciro; Tempia, Stefano. - In: ELIFE. - ISSN 2050-084X. - 12:(2023), p. e84753. [10.7554/eLife.84753]

Association of close-range contact patterns with SARS-CoV-2: a household transmission study

Tizzoni, Michele;Cattuto, Ciro
Penultimo
;
2023-01-01

Abstract

Background: Households are an important location for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, especially during periods when travel and work was restricted to essential services. We aimed to assess the association of close-range contact patterns with SARS-CoV2 transmission.Methods: We deployed proximity sensors for two weeks to measure face-to- face interactions between household members after SARS-CoV- 2 was identified in the household, in South Africa, 2020-2021. We calculated the duration, frequency, and average duration of close-range proximity events with SARS-CoV-2 index cases. We assessed the association of contact parameters with SARS-CoV2 transmission using mixed effects logistic regression accounting for index and household member characteristics.Results: We included 340 individuals (88 SARS-CoV- 2 index cases and 252 household members). On multivariable analysis, factors associated with SARS-CoV- 2 acquisition were index cases with minimum Ct value <30 (aOR 16.8 95% CI 3.1-93.1) vs >35, and female contacts (aOR 2.5 95% CI 1.3-5.0). No contact parameters were associated with acquisition (aOR 1.0-1.1) for any of the duration, frequency, cumulative time in contact, or average duration parameters.Conclusions: We did not find an association between close-range proximity events and SARS-CoV-2 household transmission. Our findings may be due to study limitations, that droplet-mediated transmission during close-proximity contacts plays a smaller role than airborne transmission of SARS-CoV-2 in the household, or due to high contact rates in households.
2023
Kleynhans, Jackie; Dall'Amico, Lorenzo; Gauvin, Laetitia; Tizzoni, Michele; Maloma, Lucia; Walaza, Sibongile; Martinson, Neil A; von Gottberg, Anne; W...espandi
Association of close-range contact patterns with SARS-CoV-2: a household transmission study / Kleynhans, Jackie; Dall'Amico, Lorenzo; Gauvin, Laetitia; Tizzoni, Michele; Maloma, Lucia; Walaza, Sibongile; Martinson, Neil A; von Gottberg, Anne; Wolter, Nicole; Makhasi, Mvuyo; Cohen, Cheryl; Cattuto, Ciro; Tempia, Stefano. - In: ELIFE. - ISSN 2050-084X. - 12:(2023), p. e84753. [10.7554/eLife.84753]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/390549
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