Repetitive Atrial Activation Patterns (RAAPs) detected in the coronary sinus (CS) during atrial fibrillation (AF) may represent a reference to construct composite maps of coincident local RAAPs elsewhere in the atria, potentially improving the identification of AF drivers. RAAP coincidence may however depend on AF complexity and may be affected by structural remodeling. Using computer simulations, we investigated coincidence and coupling of RAAPs in the CS and other regions in the atria, in the absence and presence of fibrosis. In our models, the CS displayed highly repetitive behavior unaffected by fibrosis. RAAP coincidence and coupling of other regions in the atria with the CS was high in the absence of fibrosis, but significantly decreased in the presence of fibrosis, most notably in the left atrium. In coincident RAAPs in the CS and atrial regions, quantification of the degree of RAAP coupling is required to provide further confirmation of the validity of employing CS electrograms as a reference for composite RAAPs maps.

Fibrosis Reduces the Coincidence of Repetitive Activation Patterns between the Coronary Sinus and Atrial Regions in Simulated Atrial Fibrillation / Van Montfoort, Margot; Marques, Victor; Ozgul, Ozan; Gharaviri, Ali; Pezzuto, Simone; Auricchio, Angelo; Bonizzi, Pietro; Schotten, Ulrich; Zeemering, Stef. - In: COMPUTING IN CARDIOLOGY. - ISSN 2325-8861. - 49:(2022). (Intervento presentato al convegno 2022 Computing in Cardiology, CinC 2022 tenutosi a Tampere, Finland nel 4th-7th Sep, 2022) [10.22489/CinC.2022.155].

Fibrosis Reduces the Coincidence of Repetitive Activation Patterns between the Coronary Sinus and Atrial Regions in Simulated Atrial Fibrillation

Pezzuto, Simone;
2022-01-01

Abstract

Repetitive Atrial Activation Patterns (RAAPs) detected in the coronary sinus (CS) during atrial fibrillation (AF) may represent a reference to construct composite maps of coincident local RAAPs elsewhere in the atria, potentially improving the identification of AF drivers. RAAP coincidence may however depend on AF complexity and may be affected by structural remodeling. Using computer simulations, we investigated coincidence and coupling of RAAPs in the CS and other regions in the atria, in the absence and presence of fibrosis. In our models, the CS displayed highly repetitive behavior unaffected by fibrosis. RAAP coincidence and coupling of other regions in the atria with the CS was high in the absence of fibrosis, but significantly decreased in the presence of fibrosis, most notably in the left atrium. In coincident RAAPs in the CS and atrial regions, quantification of the degree of RAAP coupling is required to provide further confirmation of the validity of employing CS electrograms as a reference for composite RAAPs maps.
2022
2022 Computing in Cardiology (CinC)
New York City
IEEE Computer Society
979-8-3503-0097-0
Fibrosis Reduces the Coincidence of Repetitive Activation Patterns between the Coronary Sinus and Atrial Regions in Simulated Atrial Fibrillation / Van Montfoort, Margot; Marques, Victor; Ozgul, Ozan; Gharaviri, Ali; Pezzuto, Simone; Auricchio, Angelo; Bonizzi, Pietro; Schotten, Ulrich; Zeemering, Stef. - In: COMPUTING IN CARDIOLOGY. - ISSN 2325-8861. - 49:(2022). (Intervento presentato al convegno 2022 Computing in Cardiology, CinC 2022 tenutosi a Tampere, Finland nel 4th-7th Sep, 2022) [10.22489/CinC.2022.155].
Van Montfoort, Margot; Marques, Victor; Ozgul, Ozan; Gharaviri, Ali; Pezzuto, Simone; Auricchio, Angelo; Bonizzi, Pietro; Schotten, Ulrich; Zeemering,...espandi
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/382809
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact