Introduction More than 300million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI.Methods and analysis EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI.Ethics and dissemination EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Munster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials.

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): study protocol for a multicentre, observational trial / Raphael, Weiss; Khaschayar, Saadat-Gilani; Laura, Kerschke; Carola, Wempe; Melanie, Meersch; Zarbock, ; Hichem Makhloufi, Alexander; Cherak, Anis; Lakhel Ghanem, Lamine; Gouaglia, Zohier; Nasrine Guadouri, Dina; Naouel Hama, Fayrouz; Kara, Mustafa; Saadi, Omayma; Sakhraoui, Rachida; Bourou, Fadila; Cherifi, Abdelhadi; Ghania Sadaoui, Rahmoune; Ouyahia, Amel; Ouahab, Ilhem; Bouaoud, Souad; Abdoun, Meriem; Tidjane, Anisse; Tabeti, Benali; Boudjenan-Serradj, Nabil; Jose Pérez Rivera, Carlos; Cabrer, Paulo; Corso, Julián; Pablo García, Juan; Idarraga, Sharon; Montoya, Christopher; Figueroa, Rafael; Aldana, Eduar; Alejandra Torrado, María; Peng, Ke; Ma, Zheng-Min; Yang, Yu-Fan; Zhu, Ya-Juan; Sklienka, Peter; Frelich, Michal; Jarkulis, Vojtech; Sevcik, Pavel; Vodicka, Vojtech; Gamal Elbahnasawy, Mohamed; Elsalhawy, Shady; Motawea, Sara; Othman, Zeinab; Sahma, Mohamed; Mahmoud Nafea, Ahmed; Ahmed, Nermin; Ali Attia, Doaa; Maher Emara, Moataz; Mamdouh Bonna, Mohamed; Ahmed Gabr, Mohamed; Ismail Tarbay, Amany; Abdelmonaem Abdehaleem, Ibrahim; Elsayed Mohamed, Esraa; Mahmoud Eldeeb, Amr; Mohamed Abbas, Ahmed; Ashraf Magdy, John; Hassan Hamed, Zyad; Mostafa Esmaeil Osman, Hany; Samy Abbas, Mostafa; Joannes-Boyau, Oliver; Barraud, Nicolas; Berthelot, Corentin; Camus, Thibault; Dahmi, Anissa; Defaye, Mylène; Derville, Sébastien; El-Boustani, Younes; Deloge, Elsa; Jacob, Hélène; Monziols, Simon; Priem, Fred; Robin, Jean-Jacques; Legros, Vincent; Floch, Therry; Muccio, Salvatore; Geneve, Claire; Lim Legouge, Marie; Tao Mauny, Stéphanie; Mfam, Willy; Pascot, Léa; Aveline, Christophe; Chartier, Mireille; Duteurtre, Benjamin; Francois Gautier, Jean; Le Cousin, Aidren; Vautier, Pierre; Nadaud, Julien; Begel, Nathalie; Chekirine, Claire-Annissa; Derlon, Vincent; Grein, Elodie; Lehair, Marie-Annick; Magazzeni, Laurent; Magazzeni, Philippe; Potter, Carsten; Roth, Catherine; Voivret, Florence; Rimmelé, Thomas; Cerro, Valérie; Suria, Stéphanie; Elmawieh, Jamil; Stoclin, Annabelle; Cirenei, Cédric; Andrieu, Gregoire; Couloumy, Sven; Falcone, Jeremy; Fajardy, Marion; Gagneuil, Arsène; Girardet, Emeline; Mazereeuw, Agnès; Ponsonnard, Sébastien; Egreteau, Pierre-Yves; Bertel, Mélanie; Bocher, Simon; Carn, Vanessa; Le Guen, Lenaïg; Le Loup, Guillaume; Lefevre, Montaine; Ichai, Carole; Diop, Amanita; Jean-Michel, Vanessa; Devlieger, Sylvie; Duthoit, Juliette; El Kadiri, Mohamed; Léger, Maxime; Cassisa, Viviane; Lasocki, Sigismond; Masson, Charline; Rineau, Emmanuel; Verrier, Pierre; Coquerel, Axel; Montravers, Philippe; Atchade, Enora; Rochon, Charles-Edouard; Delerue, Céline; Quentin, Vidal; Latry, Vanessa; Queixalos, Nina; Cottenceau, Vincent; Braun, Thierry; Bouzoubaa, Saad; Christ, Basile; Geiger, Audrey; Gomille, Joachim; Kieffer, Vianney; Mangeant, Simone; Prochilo, Christelle; Schmitt, Christian; Skwirba, Stefan; Grand, Hubert; Boury, Frédérique; Mayeur, Nicolas; Pasquie, Marie; Garçon, Pierre; Bruckert, Vincent; Arnould, Vincent; Bonciu, Mona; Chapelle, Thibault; Facchino, Luc; Fagot-Gandet, Florence; Iachim, Andrea; Mannu, Elena; Perus, Olivier; Plattier, Rémi; Rozier, Romain; Pradel, Gaël; Boudinaud, Michel; Hausermann, Marie-Hélène; Hue Nguyen, My; Ramorasata, Andersen; Barreau, Amélie; Boivin, Anne-Hélène; Ravry, Céline; Mottard, Nicolas; Beuvelot, Johanne; Prunier Bossion, Florence; Desebbe, Olivier; Zarbock, Alexander; Dörr, Christian; Caspar von Groote, Thilo; Küllmar, Mira; Massoth, Christina; Meersch, Melanie; Saadat-Gilani, Khaschayar; Weiss, Raphael; Wempe, Carola; Ziemann, Sebastian; Grüßer, Linda; Kowark, Ana; Wittig, Pia; Brandenburger, Timo; Dimski, Thomas; Döhmen, Niklas; Huthmann, Laura; Kaierle, Daniela; Pelletier, Claude; Schleß, Manon; Hohn, Andreas; Cleophas, Sebastian; Haunhorst, Stephanie; Jansen, Marina; Schmitt, Alexandra; Soisch, Julia; Sturm, Kilian; Rosenberger, Peter; Bendig, Alexander; Flohr, Lena; Häberle, Helene; Hofmann, Pascal; Kuhle, Jonathan; Michaela Leser, Nora; Pfister, Kathrin; Prohaska, Stefanie; Sennholz, Franziska; Stetz, Lena; Weber, Kathrin; Stehr, Sebastian; Klaus, Stephan; Sadlo, Marco; Boschin, Matthias; Sengelhoff, Christian; Michael Göbel, Ulrich; Gerrit Haaker, Jan; Göttker, Carina-Kristin; Gründel, Matthias; Heringlake, Matthias; Baumgärtel, Romina; Berggren, Astrid; Gülzow, Madeleine; Muras, Lennart; Paarmann, Hauke; Thal, Serge; Bentley, Alexander; El-Masri, Dschamil; Sebastiani, Anne; Arnaoutoglou, Eleni; Ntalouka, Maria; Stratigopoulou, Paula; Analytis, Anastasia; Mavrommatis, Efthymios; Tzimas, Petros; Karakosta, Agathi; Pantazi, Danai; Dimakopoulou, Antonia; Dimitropoulou, Katerina; Ioannidis, Orestis; Jalaawiy, Humam; Anwar, Aeshah; Talib Hashim, Hashim; Imad Rasheed Aldawoody, Hogir; Cortegiani, Andrea; Catalisano, Giulia; Ingoglia, Gilia; Ippolito, Mariachiara; De Rosa, Silvia; Cattin, Lucia; Bianchin, Andrea; Barone, Marisa; Paternoster, Gianluca; Lucio Cutuli, Salvatore; Russo, Andrea; Sollazzi, Liliana; Cascarano, Laura; Antonelli, Massimo; Aceto, Paola; Romanò, Bruno; Spadaro, Savino; Francesco Tripodi, Vincenzo; Rossi, Michele; Scappatura, Rosamaria; Cristina Vadalà, Maria; Fiume, Diego; Teresa Strano, Maria; Oddo, Giulia; Santorsola, Clemente; Abu Hussain, Bilal; Raed Alnaser, Adnan; Hassouneh Ghassan, Anas; Hasanein, Khaled; Theab, Mohammed; Shin, Seokyung; Jung, Seungho; Lee, Kyuho; Mee Jung, Sung; Baek, Jongyoon; K Elhadi, Muhammed; Abuzeid, Issa; Albaraesi, Mohammed; Aldressi, Sarah; Khalel, Wegdan; Abdulwahed, Eman; Abdulhamid Ashur Abujrad, Akram; Almaghrabi, Amer; Mohammed Alteleeb, Muhand; Ahmed Ali Alshareea, Entisar; Isa Biala, Marwa; Deeknah, Abdulqudus; Ali Gheddim, Dooua; Ghmagh, Reem; Salih Ali AbuIkhrays, Nawras; Sinan, Marwa; Soula, Enas; Ghayth Bahroun, Sumayyah; Derwish, Khawla; Munir Mohamed, Aya; Sayed Younes, Eman; Al Islam Benjouira, Rayet; Aliwa, Mohamed; Abdullah Altashani, Najwa; Omar Alteb, Mohammed; Msherghi, Ahmed; Alagelli, Fatima; Albarouni, Sufyan; Albishti, Ahmed; Aljamal, Sarah; Alsori, Mohamed; Ekhuja, Taha; Elzwai, Suha; Ghula, Mohammed; Mustafa, Tahani; Tuwaib, Ahmed; Zriba, Haifa; Mahmoud Agilla, Hamza; Andriamahefa Rafanomezantsoa, Toky; Marie Camilleri Podesta, Anne; Mifsud Bonnici, Denise; Pirotta, Tiziana; Adrián Gasca López, Gilberto; Mojsova Mijovska, Maja; Davitkovska, Tatjana; Gavrilovska, Aleksandra; Lukikj, Sanja; Vesova, Marija; Zafirova, Dina; Amro, Sarah; F Hajjaj, Baraa N; Alkhazendar, Muawia; Barakat, Yousuf; Abdulaziz Elejla, Sewar; Elhissi, Ahmed; Khader, Ahmed; Salem, Ali; de Freitas Regufe, Rita; Filipe de Oliveira Eloy, André; Marisa Neto Cordeiro Perdigão, Lisbete; Grigoriev, Evgeny; Ivkin, Artem; Kornelyuk, Roman; Yaroustovsky, Michael; Abramyan, Marina; Komardina, Ekaterina; Lesteva, Nataliya; Aybazova, Medina; Kumykova, Elmira; Lesina, Svetlana; Rybakov, Gennady; Shestov, Alexey; Ahmad Ahmad Barmou, Abdulnaser; Lotfi Altayeb Ahmed, Bushra; Mohammad Eliyas, Aisha; Emadeldin, Yousra; Kaserer, Alexander; Castellucci, Clara; Rössler, Julian; Akbas, Samira; Möller Petrun, Andreja; Gregorcic, Irena; Sok, Vesna; Čičak, Roman; Bárcena, Elizabeth; Guisado, Antonio; Wi, Ismail; Ripollés Melchor, Javier; Becerra-Bolaños, Ángel; Cabrera-Doreste, Sergio; Domínguez-Arbelo, Ancor; Candelaria Delgado-Alonso, María; Muiño-Palomar, Virginia; Rodríguez-Pérez, Aurelio; Mata Estévez, Javier; Begona Covas Munoz, Maria; Mulet Matas, Juan; Perez Palao, Sara; Dolores Mira Quirós, Maria; Cezara Teslev, Alisia; Garcia Alvarez, Mercedes; Argilaga, Marga; Campos, María; Bainac, Albert; Batalla, Astrid; Garcia Alvarez, Mercedes; Giné, Marta; Herránz, Gracia; Hinojal, Ignacio; Logroño Ejea, Margarita; de la Rosa Ruiz, Noelia; Gastaca Abasolo, María; Rosario Houhton Acuna, Carla; Iriarte Zaranton, Ibai; Mendigurenmurua, Ana; José Munoz Sanz, María; Olea de la Fuente, Erika; Pilar Pérez Vaquero, María; Soto Iglesias, Ana; Ugarte Mieres, Ana; Urtiaga Urrestizala, Alaitz; Ferreira, Lourdes; Lobato, Félix; Aguado Sevilla, Marta; Erazo, Andres; Miró, Pere; Sabaté, Sergi; Vernetta, Diana; Castellano Paulis, Berta; Adell Perez, Anabel; Aseguinolaza Pagola, Marta; Castellano Paulis, Berta; delVal Peciña, Elena; Garmendia Odriozola, Ainhoa; Lopetegi Aizpurua, Amaia; Pavón Piquer, Olatz; Plou Garcia, Pilar; Ortega Rezola, Paula; Osorio Lopez, Antia; de la Calle Gil, Isabel; Navarro Casado, Rosalía; Adamove, Peter; Bayona Domenge, Roser; Miguel Blasco Blasco, Francho; Alexandra Rueda Villamizar, Adriana; Antonia Perelló Llaneras, Maria; Ignacio García-Sánchez, Jose; Fernandez Téllez, Laura; García Zamorano, Sara; Gijón Herreros, Natalia; Rodriguez Esteve, Andrea; Monedero Rodríguez, Pablo; García Trigo, Isabel; Alcaraz, Agustín; Lara Jiménez, Andrea; Rubio, Iñigo; García, Nuria; Callejas, Raquel; Manuel Candela Toha, Angel; Claros, Eli; Cobeta, Pilar; Crespo, Pascual; Dorado, Trini; Elías, Elena; Felices, Javier; Gil, Diego; Gómez, María; Mané, Nuria; Martín, María; Martínez, Adolfo; Pereira, Lucía; Balvis Noemí Samaranch, Alberto; Serrano, Ana; Tiscar, Carlos; Villahoz, Judith; Galán Menéndez, Patricia; Cardona, Elena; Conesa, Anna; Estepa, Veronica; Galán, Patricia; Llinares Espí, Laura; Loaiza Aldeán, Yuri; Manrique, Susana; Morales Ariza, Víctor; Villarino Villa, Laura; Saidahmed Mohamed Amed Suliman, Elfayadh; Hamid, Hytham; Mohamed Ibrahim, Ahmed; Mohamed Saeed, Modather; Sungur Mukadder, Orhan; Altun, Demet; Canbolat, Nur; Beril Dinçer, Müşerref; Özkan Seyhan, Tulay; Aktaş Yıldırım, Serap; İyigün, Müzeyyen; Yapıcı, Davut; Özdemir, Levent; Sagun, Aslinur; Boztug, Neval; Cetintas, Yesim; Dinc, Bora; Gündüz, Emel; Ünlügenç, Hakkı; Lafli Tunay, Demet; Karakaya, Deniz; Dost, Burhan; Komurcu, Ozgur; Korkmaz Dilmen, Özlem; Fatma Akcil, Eren; Korkmaz Dilmen, Özlem; Tunali, Yusuf; Ok, Gülay; Tok Alsina, Eda; Hakli, Özge; Polat, Cengiz; Turgut, Namigar; Kızılcık, Nurcan; Köner, Özge; Şen, Öznur; Aydin, Nurdan; Basaran, Burcu; Sertac Bingul, Emre; Gürkan, Yavuz; Darcin, Kamil; Ugur, Semra; Tolga Saracoglu, Kemal; Demir, Asli; Aysegül, Özgök; Balci, Eda; Girgin, Behic; Guler, Aygun; Karadeniz, Ümit; Özaslan, Nihal; Özay Hülya, Yigit; Ozcan, Namik; Postaci, Aysun; Sahap, Mehmet; Salman, Nevriye; Sağır, Özlem; Atik, Bulent; Bicakcioglu, Murat; Fisun Demir, Hafize; Fatih, Ugün; Kocaoglu, Nazan; Ilksen Toprak, Hüseyin; Demiröz Aslan, Duygu; Ziya Colak, Yusuf; Soner Ozcan, Mustafa; Yilmaz, Mehmet; Karaca, Umran; Hekimoglu Sahin, Sevtap; Ersoy Karka, Özlem; Demir Şenoğlu, Gizem; Erkoç Karadağ, Süheyla; Alkis, Neslihan; Baytaş, Volkan; Erturk, Engin; Akdogan, Ali; Besir, Ahmet; Erturk, Engin; Kutanis, Dilek; Saylan, Sedat; Tugcugil, Ersagun; Ayvat, Pinar; Günaydın, Berrin; Mehri Büyükgebiz, Beyza; Faruk Boran, Omer; Calisir, Feyza; Orak, Yavuz; Kuvaki Balkan, Bahar; Kuvaki Balkan, Bahar; Büyükcoban, Sibel; Gökel, Erol; Ferim Günenc, Sakize; Özbilgin, Sule; Göre, Suna; Akesen, Selcan; Cansabuncu, Seda; Momot, Natalia; Panchenko, Anna; Pittet, Jean-Francois; Rutledge, Kristen. - In: BMJ OPEN. - ISSN 2044-6055. - 11:12(2021), pp. e0557051-e0557059. [10.1136/bmjopen-2021-055705]

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): study protocol for a multicentre, observational trial

Silvia De Rosa;
2021-01-01

Abstract

Introduction More than 300million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI.Methods and analysis EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI.Ethics and dissemination EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Munster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials.
2021
12
Raphael, Weiss; Khaschayar, Saadat-Gilani; Laura, Kerschke; Carola, Wempe; Melanie, Meersch; Zarbock, ; Hichem Makhloufi, Alexander; Cherak, Anis; Lak...espandi
EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): study protocol for a multicentre, observational trial / Raphael, Weiss; Khaschayar, Saadat-Gilani; Laura, Kerschke; Carola, Wempe; Melanie, Meersch; Zarbock, ; Hichem Makhloufi, Alexander; Cherak, Anis; Lakhel Ghanem, Lamine; Gouaglia, Zohier; Nasrine Guadouri, Dina; Naouel Hama, Fayrouz; Kara, Mustafa; Saadi, Omayma; Sakhraoui, Rachida; Bourou, Fadila; Cherifi, Abdelhadi; Ghania Sadaoui, Rahmoune; Ouyahia, Amel; Ouahab, Ilhem; Bouaoud, Souad; Abdoun, Meriem; Tidjane, Anisse; Tabeti, Benali; Boudjenan-Serradj, Nabil; Jose Pérez Rivera, Carlos; Cabrer, Paulo; Corso, Julián; Pablo García, Juan; Idarraga, Sharon; Montoya, Christopher; Figueroa, Rafael; Aldana, Eduar; Alejandra Torrado, María; Peng, Ke; Ma, Zheng-Min; Yang, Yu-Fan; Zhu, Ya-Juan; Sklienka, Peter; Frelich, Michal; Jarkulis, Vojtech; Sevcik, Pavel; Vodicka, Vojtech; Gamal Elbahnasawy, Mohamed; Elsalhawy, Shady; Motawea, Sara; Othman, Zeinab; Sahma, Mohamed; Mahmoud Nafea, Ahmed; Ahmed, Nermin; Ali Attia, Doaa; Maher Emara, Moataz; Mamdouh Bonna, Mohamed; Ahmed Gabr, Mohamed; Ismail Tarbay, Amany; Abdelmonaem Abdehaleem, Ibrahim; Elsayed Mohamed, Esraa; Mahmoud Eldeeb, Amr; Mohamed Abbas, Ahmed; Ashraf Magdy, John; Hassan Hamed, Zyad; Mostafa Esmaeil Osman, Hany; Samy Abbas, Mostafa; Joannes-Boyau, Oliver; Barraud, Nicolas; Berthelot, Corentin; Camus, Thibault; Dahmi, Anissa; Defaye, Mylène; Derville, Sébastien; El-Boustani, Younes; Deloge, Elsa; Jacob, Hélène; Monziols, Simon; Priem, Fred; Robin, Jean-Jacques; Legros, Vincent; Floch, Therry; Muccio, Salvatore; Geneve, Claire; Lim Legouge, Marie; Tao Mauny, Stéphanie; Mfam, Willy; Pascot, Léa; Aveline, Christophe; Chartier, Mireille; Duteurtre, Benjamin; Francois Gautier, Jean; Le Cousin, Aidren; Vautier, Pierre; Nadaud, Julien; Begel, Nathalie; Chekirine, Claire-Annissa; Derlon, Vincent; Grein, Elodie; Lehair, Marie-Annick; Magazzeni, Laurent; Magazzeni, Philippe; Potter, Carsten; Roth, Catherine; Voivret, Florence; Rimmelé, Thomas; Cerro, Valérie; Suria, Stéphanie; Elmawieh, Jamil; Stoclin, Annabelle; Cirenei, Cédric; Andrieu, Gregoire; Couloumy, Sven; Falcone, Jeremy; Fajardy, Marion; Gagneuil, Arsène; Girardet, Emeline; Mazereeuw, Agnès; Ponsonnard, Sébastien; Egreteau, Pierre-Yves; Bertel, Mélanie; Bocher, Simon; Carn, Vanessa; Le Guen, Lenaïg; Le Loup, Guillaume; Lefevre, Montaine; Ichai, Carole; Diop, Amanita; Jean-Michel, Vanessa; Devlieger, Sylvie; Duthoit, Juliette; El Kadiri, Mohamed; Léger, Maxime; Cassisa, Viviane; Lasocki, Sigismond; Masson, Charline; Rineau, Emmanuel; Verrier, Pierre; Coquerel, Axel; Montravers, Philippe; Atchade, Enora; Rochon, Charles-Edouard; Delerue, Céline; Quentin, Vidal; Latry, Vanessa; Queixalos, Nina; Cottenceau, Vincent; Braun, Thierry; Bouzoubaa, Saad; Christ, Basile; Geiger, Audrey; Gomille, Joachim; Kieffer, Vianney; Mangeant, Simone; Prochilo, Christelle; Schmitt, Christian; Skwirba, Stefan; Grand, Hubert; Boury, Frédérique; Mayeur, Nicolas; Pasquie, Marie; Garçon, Pierre; Bruckert, Vincent; Arnould, Vincent; Bonciu, Mona; Chapelle, Thibault; Facchino, Luc; Fagot-Gandet, Florence; Iachim, Andrea; Mannu, Elena; Perus, Olivier; Plattier, Rémi; Rozier, Romain; Pradel, Gaël; Boudinaud, Michel; Hausermann, Marie-Hélène; Hue Nguyen, My; Ramorasata, Andersen; Barreau, Amélie; Boivin, Anne-Hélène; Ravry, Céline; Mottard, Nicolas; Beuvelot, Johanne; Prunier Bossion, Florence; Desebbe, Olivier; Zarbock, Alexander; Dörr, Christian; Caspar von Groote, Thilo; Küllmar, Mira; Massoth, Christina; Meersch, Melanie; Saadat-Gilani, Khaschayar; Weiss, Raphael; Wempe, Carola; Ziemann, Sebastian; Grüßer, Linda; Kowark, Ana; Wittig, Pia; Brandenburger, Timo; Dimski, Thomas; Döhmen, Niklas; Huthmann, Laura; Kaierle, Daniela; Pelletier, Claude; Schleß, Manon; Hohn, Andreas; Cleophas, Sebastian; Haunhorst, Stephanie; Jansen, Marina; Schmitt, Alexandra; Soisch, Julia; Sturm, Kilian; Rosenberger, Peter; Bendig, Alexander; Flohr, Lena; Häberle, Helene; Hofmann, Pascal; Kuhle, Jonathan; Michaela Leser, Nora; Pfister, Kathrin; Prohaska, Stefanie; Sennholz, Franziska; Stetz, Lena; Weber, Kathrin; Stehr, Sebastian; Klaus, Stephan; Sadlo, Marco; Boschin, Matthias; Sengelhoff, Christian; Michael Göbel, Ulrich; Gerrit Haaker, Jan; Göttker, Carina-Kristin; Gründel, Matthias; Heringlake, Matthias; Baumgärtel, Romina; Berggren, Astrid; Gülzow, Madeleine; Muras, Lennart; Paarmann, Hauke; Thal, Serge; Bentley, Alexander; El-Masri, Dschamil; Sebastiani, Anne; Arnaoutoglou, Eleni; Ntalouka, Maria; Stratigopoulou, Paula; Analytis, Anastasia; Mavrommatis, Efthymios; Tzimas, Petros; Karakosta, Agathi; Pantazi, Danai; Dimakopoulou, Antonia; Dimitropoulou, Katerina; Ioannidis, Orestis; Jalaawiy, Humam; Anwar, Aeshah; Talib Hashim, Hashim; Imad Rasheed Aldawoody, Hogir; Cortegiani, Andrea; Catalisano, Giulia; Ingoglia, Gilia; Ippolito, Mariachiara; De Rosa, Silvia; Cattin, Lucia; Bianchin, Andrea; Barone, Marisa; Paternoster, Gianluca; Lucio Cutuli, Salvatore; Russo, Andrea; Sollazzi, Liliana; Cascarano, Laura; Antonelli, Massimo; Aceto, Paola; Romanò, Bruno; Spadaro, Savino; Francesco Tripodi, Vincenzo; Rossi, Michele; Scappatura, Rosamaria; Cristina Vadalà, Maria; Fiume, Diego; Teresa Strano, Maria; Oddo, Giulia; Santorsola, Clemente; Abu Hussain, Bilal; Raed Alnaser, Adnan; Hassouneh Ghassan, Anas; Hasanein, Khaled; Theab, Mohammed; Shin, Seokyung; Jung, Seungho; Lee, Kyuho; Mee Jung, Sung; Baek, Jongyoon; K Elhadi, Muhammed; Abuzeid, Issa; Albaraesi, Mohammed; Aldressi, Sarah; Khalel, Wegdan; Abdulwahed, Eman; Abdulhamid Ashur Abujrad, Akram; Almaghrabi, Amer; Mohammed Alteleeb, Muhand; Ahmed Ali Alshareea, Entisar; Isa Biala, Marwa; Deeknah, Abdulqudus; Ali Gheddim, Dooua; Ghmagh, Reem; Salih Ali AbuIkhrays, Nawras; Sinan, Marwa; Soula, Enas; Ghayth Bahroun, Sumayyah; Derwish, Khawla; Munir Mohamed, Aya; Sayed Younes, Eman; Al Islam Benjouira, Rayet; Aliwa, Mohamed; Abdullah Altashani, Najwa; Omar Alteb, Mohammed; Msherghi, Ahmed; Alagelli, Fatima; Albarouni, Sufyan; Albishti, Ahmed; Aljamal, Sarah; Alsori, Mohamed; Ekhuja, Taha; Elzwai, Suha; Ghula, Mohammed; Mustafa, Tahani; Tuwaib, Ahmed; Zriba, Haifa; Mahmoud Agilla, Hamza; Andriamahefa Rafanomezantsoa, Toky; Marie Camilleri Podesta, Anne; Mifsud Bonnici, Denise; Pirotta, Tiziana; Adrián Gasca López, Gilberto; Mojsova Mijovska, Maja; Davitkovska, Tatjana; Gavrilovska, Aleksandra; Lukikj, Sanja; Vesova, Marija; Zafirova, Dina; Amro, Sarah; F Hajjaj, Baraa N; Alkhazendar, Muawia; Barakat, Yousuf; Abdulaziz Elejla, Sewar; Elhissi, Ahmed; Khader, Ahmed; Salem, Ali; de Freitas Regufe, Rita; Filipe de Oliveira Eloy, André; Marisa Neto Cordeiro Perdigão, Lisbete; Grigoriev, Evgeny; Ivkin, Artem; Kornelyuk, Roman; Yaroustovsky, Michael; Abramyan, Marina; Komardina, Ekaterina; Lesteva, Nataliya; Aybazova, Medina; Kumykova, Elmira; Lesina, Svetlana; Rybakov, Gennady; Shestov, Alexey; Ahmad Ahmad Barmou, Abdulnaser; Lotfi Altayeb Ahmed, Bushra; Mohammad Eliyas, Aisha; Emadeldin, Yousra; Kaserer, Alexander; 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[10.1136/bmjopen-2021-055705]
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