Purpose: To accommodate the unprecedented number of critically ill patients with pneumonia caused by coronavirus disease 2019 (COVID-19) expansion of the capacity of intensive care unit (ICU) to clinical areas not previously used for critical care was necessary. We describe the global burden of COVID-19 admissions and the clinical and organizational characteristics associated with outcomes in critically ill COVID-19 patients. Methods: Multicenter, international, point prevalence study, including adult patients with SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) and a diagnosis of COVID-19 admitted to ICU between February 15th and May 15th, 2020. Results: 4994 patients from 280 ICUs in 46 countries were included. Included ICUs increased their total capacity from 4931 to 7630 beds, deploying personnel from other areas. Overall, 1986 (39.8%) patients were admitted to surge capacity beds. Invasive ventilation at admission was present in 2325 (46.5%) patients and was required during ICU stay in 85.8% of patients. 60-day mortality was 33.9% (IQR across units: 20%-50%) and ICU mortality 32.7%. Older age, invasive mechanical ventilation, and acute kidney injury (AKI) were associated with increased mortality. These associations were also confirmed specifically in mechanically ventilated patients. Admission to surge capacity beds was not associated with mortality, even after controlling for other factors. Conclusions: ICUs responded to the increase in COVID-19 patients by increasing bed availability and staff, admitting up to 40% of patients in surge capacity beds. Although mortality in this population was high, admission to a surge capacity bed was not associated with increased mortality. Older age, invasive mechanical ventilation, and AKI were identified as the strongest predictors of mortality.

Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study / Massimiliano, Greco; Thomas, De Corte; Ari, Ercole; Massimo, Antonelli; Elie, Azoulay; Giuseppe, Citerio; Andy Conway, Morris; Gennaro, De Pascale; Frantisek, Duska; Paul, Elbers; Sharon, Einav; Lui, Forni; Laura, Galarza; Armand R J, Girbes; Giacomo, Grasselli; Vitaly, Gusarov; Alasdair, Jubb; Jozef, Kesecioglu; Andrea, Lavinio; Maria Cruz Martin, Delgado; Johannes, Mellinghoff; Sheila Nainan, Myatra; Marlies, Ostermann; Mariangela, Pellegrini; Pedro, Povoa; Stefan J, Schaller; Jean-Louis, Teboul; Adrian, Wong; Jan J, De Waele; Maurizio, Cecconi; Bezzi, Marco; Gira, Alicia; Eller, Philipp; Hamid, Tarikul; Ull Haque, Injamam; De Buyser, Wim; Cudia, Antonella; De Backer, Daniel; Foulon, Pierre; Collin, Vincent; De Waele, Jan; Van Hecke, Jolien; De Waele, Elisabeth; Van Malderen, Claire; Mesland, Jean-Baptiste; Biston, Patrick; Piagnerelli, Michael; Haentjens, Lionel; De Schryver, Nicolas; Van Leemput, Jan; Vanhove, Philippe; Bulpa, Pierre; Ilieva, Viktoria; Katz, David; Binnie, Alexandra; Geagea, Anna; Tirapegui, Fernando; Lago, Gustavo; Graf, Jerónimo; Perez-Araos, Rodrigo; Vargas, Patricio; Martinez, Felipe; Labarca, Eduardo; Molano Franco, Daniel; Parra-Tanoux, Daniela; Felipe Reyes, Luis; Yepes, David; Periš, Filip; Stojanović Stipić, Sanda; Vanessa Campozano Burgos, Cynthia; Roberto Navas Boada, Paulo; Luis Barberan Brun, Jose; Pablo Paredes Ballesteros, Juan; Abdelnasser, Gamal; Hammouda, Ahmed; Elmandouh, Omar; Azzam, Ahmed; Mohamed Hussein, Aliae; Galal, Islam; Awad, Ahmed K.; Azab, Mohammed A.; Abdalla, Maged; Assal, Hebatallah; Alfishawy, Mostafa; Ghozy, Sherief; Tharwat, Samar; Eldaly, Abdullah; Ellervee, Anneli; Reinhard, Veronika; Chrisment, Anne; Poyat, Chrystelle; Badie, Julio; Berdaguer Ferrari, Fernando; Weiss, Björn; Schellenberg, Clara; Grunow, Julius J.; Lorenz, Marco; Schaller, Stefan J.; Spieth, Peter; Bota, Marc; Fichtner, Falk; Fuest, Kristina; Lahmer, Tobias; Herrmann, Johannes; Meybohm, Patrick; Markou, Nikolaos; Vasileiadou, Georgia; Chrysanthopoulou, Evangelia; Papamichalis, Panagiotis; Soultati, Ioanna; Jog, Sameer; Kalvit, Kushal; Nainan Myatra, Sheila; Krupa, Ivan; Tharwat, Aisa; Nichol, Alistair; Mccarthy, Aine; Mahmoodpoor, Ata; Tonetti, Tommaso; Isoni, Paolo; Spadaro, Savino; Alberto Volta, Carlo; Mirabella, Lucia; Noto, Alberto; Florio, Gaetano; Guzzardella, Amedeo; Paleari, Chiara; Baccanelli, Federica; Savi, Marzia; Antonelli, Massimo; De Pascale, Gennaro; Luca, San; Vaccarini, Barbara; Montrucchio, Giorgia; Sales, Gabriele; Donadello, Katia; Gottin, Leonardo; Nizzero, Marta; Polati, Enrico; De Rosa, Silvia; Sulemanji, Demet; Abusalama, Abdurraouf; Elhadi, Muhammed; De FelipeJesus, Montelongo; Rodriguez Gonzalez, Daniel; Hugo Madrigal Robles, Victor; Canedo, Nancy; Esquivel Chavez, Alejandro; Dendane, Tarek; Grady, Bart; de Jong, Ben; van der Heiden, Eveline; Thoral, Patrick; van den Bogaard, Bas; Spronk, Peter E.; Achterberg, Sefanja; Groeneveld, Melanie; So, Ralph K. L.; de Wijs, Calvin; Scholten, Harm; Beishuizen, Albertus; Cornet, Alexander D.; Reidinga, Auke C.; Kranen, Hetty; Mensink, Roos; Gasthuis, Spaarne; den Boer, Sylvia; de Groot, Marcel; Beck, Oliver; Bethlehem, Carina; van Bussel, Bas; Frenzel, Tim; de Jong, Celestine; Wilting, Rob; Kesecioglu, Jozef; Mehagnoul-Schipper, Jannet; Alasia, Datonye; Kumar, Ashok; Qayyum, Ahad; Rana, Muhammad; Abu Jayyab, Mustafa; Quispe Sierra, Rosario; Mark Hernandez, Aaron; de Almeida, José; Taborda, Lúcia; Anselmo, Mónica; Ramires, Tiago; Silva, Catarina; Roriz, Carolina; Morais, Rui; Póvoa, Pedro; Patricio, Patricia; Pinto, André; Lurdes Santos, Maria; Costa, Vasco; Cunha, Pedro; Gonçalves, Celina; Nunes, Sandra; Camões, João; Adrião, Diana; Oliveira, Ana; Omrani, Ali; Al Maslamani, Muna; Suei elbuzidi, Abdurrahmaan; Mahmoud Al qudah, Bara; Rauof Akkari, Abdel; Alkhatteb, Mohamed; Baiou, Anas; Husain, Ahmed; Alwraidat, Mohamed; Abdulsalam Saif, Ibrahim; Bakdach, Dana; Ahmed, Amna; Aleef, Mohamed; Bintaher, Awadh; Petrisor, Cristina; Popov, Evgeniy; Popova, Ksenia; Dementienko, Mariia; Teplykh, Boris; Pyregov, Alexey; Davydova, Liubov; Vladislav, Belskii; Neporada, Elena; Zverev, Ivan; Meshchaninova, Svetlana; Sokolov, Dmitry; Gavrilova, Elena; Shlyk, Irina; Poliakov, Igor; Vlasova, Marina; Aljuhani, Ohoud; Alkhalaf, Amina; Bin Humaid, Felwa; Arabi, Yaseen; Kuhail, Ahmed; Elrabi, Omar; Ghannam, Madihah E.; Teng Fong, Ng; Kansal, Amit; Kian Ho, Vui; Ng, Jensen; Rodrígez García, Raquel; Taboada Fraga, Xiana; del Pilar García-Bonillo, Mª; Padilla-Serrano, Antonio; Martin Cuadrado, Marta; Ferrando, Carlos; Catalan-Monzon, Ignacio; Galarza, Laura; Frutos-Vivar, Fernando; Jimenez, Jorge; Rodríguez-Solis, Carmen; Franquesa-Gonzalez, Enric; Pérez Acosta, Guillermo; Santana Cabrera, Luciano; Pablo Aviles Parra, Juan; Muñoyerro Gonzalez, Francisco; del Carmen Lorente Conesa, Maria; Yago Martinez Varela, Ignacio; Victoriano Baez Pravia, Orville; Cruz Martin Delgado, Maria; Munoz de Cabo, Carlos; Ioan, Ana-Maria; Perez-Calvo, Cesar; Santos, Arnoldo; Abad-Motos, Ane; Ripolles-Melchor, Javier; Civantos Martin, Belén; Yus Teruel, Santiago; Higuera Lucas, Juan; Blandino Ortiz, Aaron; de Pablo Sánchez, Raúl; Emilio Barrueco-Francioni, Jesús; Forcelledo Espina, Lorena; Bonell-Goytisolo, José M.; Salaverria, Iñigo; Socias Mir, Antonia; Rodriguez-Ruiz, Emilio; Hidalgo Valverde, Virginia; Jimeno Cubero, Patricia; Arbol Linde, Francisca; Cruza Leganes, Nieves; Maria Romeu, Juan; Concha, Pablo; Angel Berezo-Garcia, José; Fraile, Virginia; Cuenca-Rubio, Cristina; Pérez-Torres, David; Serrano, Ainhoa; Martínez Valero, Clara; Ortiz Suner, Andrea; Larrañaga, Leire; Legaristi, Noemi; Ferrigno, Gerardo; Khlafalla, Safa; Bihariesingh-Sanchit, Rosita; Sjukhus, Hallands; Zoerner, Frank; Grip, Jonathan; Kilsand, Kristina; Mårtensson, Johan; Österlind, Jonas; Sjukhuset, Akademiska; von Seth, Magnus; Sjukhus, Västerviks; Berkius, Johan; Ceruti, Samuele; Glotta, Andrea; Izdes, Seval; Özkoçak Turan, Işıl; Cosar, Ahmet; Halacli, Burcin; Dereli, Necla; Yilmaz, Mehmet; Akbas, Türkay; Elay, Gülseren; Eyüpoğlu, Selin; Bílír, Yelíz; Tolga Saraçoğlu, Kemal; Kaya, Ebru; Sultan Sahin, Ayca; Korkmaz Ekren, Pervin; Mengi, Tuğçe; Ozmen Suner, Kezban; Tomak, Yakup; Eroglu, Ahmet; Alsabbah, Asad; Hanlon, Katie; Gervin, Kevin; Mcmahon, Sean; Hagan, Samantha; Higenbottam, Caroline V.; Mullhi, Randeep; Poulton, Lottie; Torlinski, Tomasz; Gareth, Allen; Truman, Nick; Vijayakumar, Gopal; Hall, Chris; Jubb, Alasdair; Cagova, Lenka; Jones, Nicola; Graham, Sam; Robin, Nicole; Cowton, Amanda; Donnelly, Adrian; Singatullina, Natalia; Kent, Melanie; Boulanger, Carole; Campbell, Zoë; Potter, Elizabeth; Duric, Natalie; Szakmany, Tamas; Brompton, Royal; Kviatkovske, Orinta; Marczin, Nandor; Ellis, Caroline; Saha, Rajnish; Sri-Chandana, Chunda; Allan, John; Mumelj, Lana; Venkatesh, Harish; Nina Gotz, Vera; Cochrane, Anthony; Ficial, Barbara; Kamble, Shruthi; Lumlertgul, Nuttha; Oddy, Christopher; Jain, Susan; Beatrice Crapelli, Giulia; Vlachou, Aikaterini; Golden, David; Garrioch, Sweyn; Henning, Jeremy; Loveleena, Gupta; Davey, Miriam; Grauslyte, Lina; Salciute-Simene, Erika; Cook, Martin; Barling, Danny; Broadhurst, Phil; Purvis, Sarah; Spivey, Michael; Shuker, Benjamin; Grecu, Irina; Harding, Daniel; Singatullina, Natalia; Dean, James T.; Nielsen, Nathan D.; Al-Bayati, Sama; Al-Sadawi, Mohammed; Charron, Mariane; Stubenrauch, Peter; Santanilla, Jairo; Wentowski, Catherine; Rosenberger, Dorothea; Eksarko, Polikseni; Randeep Jawa, And. - In: INTENSIVE CARE MEDICINE. - ISSN 0342-4642. - 48:6(2022), pp. 690-705. [10.1007/s00134-022-06705-1]

Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study

Katia Donadello;Silvia De Rosa;
2022-01-01

Abstract

Purpose: To accommodate the unprecedented number of critically ill patients with pneumonia caused by coronavirus disease 2019 (COVID-19) expansion of the capacity of intensive care unit (ICU) to clinical areas not previously used for critical care was necessary. We describe the global burden of COVID-19 admissions and the clinical and organizational characteristics associated with outcomes in critically ill COVID-19 patients. Methods: Multicenter, international, point prevalence study, including adult patients with SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) and a diagnosis of COVID-19 admitted to ICU between February 15th and May 15th, 2020. Results: 4994 patients from 280 ICUs in 46 countries were included. Included ICUs increased their total capacity from 4931 to 7630 beds, deploying personnel from other areas. Overall, 1986 (39.8%) patients were admitted to surge capacity beds. Invasive ventilation at admission was present in 2325 (46.5%) patients and was required during ICU stay in 85.8% of patients. 60-day mortality was 33.9% (IQR across units: 20%-50%) and ICU mortality 32.7%. Older age, invasive mechanical ventilation, and acute kidney injury (AKI) were associated with increased mortality. These associations were also confirmed specifically in mechanically ventilated patients. Admission to surge capacity beds was not associated with mortality, even after controlling for other factors. Conclusions: ICUs responded to the increase in COVID-19 patients by increasing bed availability and staff, admitting up to 40% of patients in surge capacity beds. Although mortality in this population was high, admission to a surge capacity bed was not associated with increased mortality. Older age, invasive mechanical ventilation, and AKI were identified as the strongest predictors of mortality.
2022
6
Massimiliano, Greco; Thomas, De Corte; Ari, Ercole; Massimo, Antonelli; Elie, Azoulay; Giuseppe, Citerio; Andy Conway, Morris; Gennaro, De Pascale; Frantisek, Duska; Paul, Elbers; Sharon, Einav; Lui, Forni; Laura, Galarza; Armand R J, Girbes; Giacomo, Grasselli; Vitaly, Gusarov; Alasdair, Jubb; Jozef, Kesecioglu; Andrea, Lavinio; Maria Cruz Martin, Delgado; Johannes, Mellinghoff; Sheila Nainan, Myatra; Marlies, Ostermann; Mariangela, Pellegrini; Pedro, Povoa; Stefan J, Schaller; Jean-Louis, Teboul; Adrian, Wong; Jan J, De Waele; Maurizio, Cecconi; Bezzi, Marco; Gira, Alicia; Eller, Philipp; Hamid, Tarikul; Ull Haque, Injamam; De Buyser, Wim; Cudia, Antonella; De Backer, Daniel; Foulon, Pierre; Collin, Vincent; De Waele, Jan; Van Hecke, Jolien; De Waele, Elisabeth; Van Malderen, Claire; Mesland, Jean-Baptiste; Biston, Patrick; Piagnerelli, Michael; Haentjens, Lionel; De Schryver, Nicolas; Van Leemput, Jan; Vanhove, Philippe; Bulpa, Pierre; Ilieva, Viktoria; Katz, David; Binnie, Alexandra; Geagea, Anna; Tirapegui, Fernando; Lago, Gustavo; Graf, Jerónimo; Perez-Araos, Rodrigo; Vargas, Patricio; Martinez, Felipe; Labarca, Eduardo; Molano Franco, Daniel; Parra-Tanoux, Daniela; Felipe Reyes, Luis; Yepes, David; Periš, Filip; Stojanović Stipić, Sanda; Vanessa Campozano Burgos, Cynthia; Roberto Navas Boada, Paulo; Luis Barberan Brun, Jose; Pablo Paredes Ballesteros, Juan; Abdelnasser, Gamal; Hammouda, Ahmed; Elmandouh, Omar; Azzam, Ahmed; Mohamed Hussein, Aliae; Galal, Islam; Awad, Ahmed K.; Azab, Mohammed A.; Abdalla, Maged; Assal, Hebatallah; Alfishawy, Mostafa; Ghozy, Sherief; Tharwat, Samar; Eldaly, Abdullah; Ellervee, Anneli; Reinhard, Veronika; Chrisment, Anne; Poyat, Chrystelle; Badie, Julio; Berdaguer Ferrari, Fernando; Weiss, Björn; Schellenberg, Clara; Grunow, Julius J.; Lorenz, Marco; Schaller, Stefan J.; Spieth, Peter; Bota, Marc; Fichtner, Falk; Fuest, Kristina; Lahmer, Tobias; Herrmann, Johannes; Meybohm, Patrick; Markou, Nikolaos; Vasileiadou, Georgia; Chrysanthopoulou, Evangelia; Papamichalis, Panagiotis; Soultati, Ioanna; Jog, Sameer; Kalvit, Kushal; Nainan Myatra, Sheila; Krupa, Ivan; Tharwat, Aisa; Nichol, Alistair; Mccarthy, Aine; Mahmoodpoor, Ata; Tonetti, Tommaso; Isoni, Paolo; Spadaro, Savino; Alberto Volta, Carlo; Mirabella, Lucia; Noto, Alberto; Florio, Gaetano; Guzzardella, Amedeo; Paleari, Chiara; Baccanelli, Federica; Savi, Marzia; Antonelli, Massimo; De Pascale, Gennaro; Luca, San; Vaccarini, Barbara; Montrucchio, Giorgia; Sales, Gabriele; Donadello, Katia; Gottin, Leonardo; Nizzero, Marta; Polati, Enrico; De Rosa, Silvia; Sulemanji, Demet; Abusalama, Abdurraouf; Elhadi, Muhammed; De FelipeJesus, Montelongo; Rodriguez Gonzalez, Daniel; Hugo Madrigal Robles, Victor; Canedo, Nancy; Esquivel Chavez, Alejandro; Dendane, Tarek; Grady, Bart; de Jong, Ben; van der Heiden, Eveline; Thoral, Patrick; van den Bogaard, Bas; Spronk, Peter E.; Achterberg, Sefanja; Groeneveld, Melanie; So, Ralph K. L.; de Wijs, Calvin; Scholten, Harm; Beishuizen, Albertus; Cornet, Alexander D.; Reidinga, Auke C.; Kranen, Hetty; Mensink, Roos; Gasthuis, Spaarne; den Boer, Sylvia; de Groot, Marcel; Beck, Oliver; Bethlehem, Carina; van Bussel, Bas; Frenzel, Tim; de Jong, Celestine; Wilting, Rob; Kesecioglu, Jozef; Mehagnoul-Schipper, Jannet; Alasia, Datonye; Kumar, Ashok; Qayyum, Ahad; Rana, Muhammad; Abu Jayyab, Mustafa; Quispe Sierra, Rosario; Mark Hernandez, Aaron; de Almeida, José; Taborda, Lúcia; Anselmo, Mónica; Ramires, Tiago; Silva, Catarina; Roriz, Carolina; Morais, Rui; Póvoa, Pedro; Patricio, Patricia; Pinto, André; Lurdes Santos, Maria; Costa, Vasco; Cunha, Pedro; Gonçalves, Celina; Nunes, Sandra; Camões, João; Adrião, Diana; Oliveira, Ana; Omrani, Ali; Al Maslamani, Muna; Suei elbuzidi, Abdurrahmaan; Mahmoud Al qudah, Bara; Rauof Akkari, Abdel; Alkhatteb, Mohamed; Baiou, Anas; Husain, Ahmed; Alwraidat, Mohamed; Abdulsalam Saif, Ibrahim; Bakdach, Dana; Ahmed, Amna; Aleef, Mohamed; Bintaher, Awadh; Petrisor, Cristina; Popov, Evgeniy; Popova, Ksenia; Dementienko, Mariia; Teplykh, Boris; Pyregov, Alexey; Davydova, Liubov; Vladislav, Belskii; Neporada, Elena; Zverev, Ivan; Meshchaninova, Svetlana; Sokolov, Dmitry; Gavrilova, Elena; Shlyk, Irina; Poliakov, Igor; Vlasova, Marina; Aljuhani, Ohoud; Alkhalaf, Amina; Bin Humaid, Felwa; Arabi, Yaseen; Kuhail, Ahmed; Elrabi, Omar; Ghannam, Madihah E.; Teng Fong, Ng; Kansal, Amit; Kian Ho, Vui; Ng, Jensen; Rodrígez García, Raquel; Taboada Fraga, Xiana; del Pilar García-Bonillo, Mª; Padilla-Serrano, Antonio; Martin Cuadrado, Marta; Ferrando, Carlos; Catalan-Monzon, Ignacio; Galarza, Laura; Frutos-Vivar, Fernando; Jimenez, Jorge; Rodríguez-Solis, Carmen; Franquesa-Gonzalez, Enric; Pérez Acosta, Guillermo; Santana Cabrera, Luciano; Pablo Aviles Parra, Juan; Muñoyerro Gonzalez, Francisco; del Carmen Lorente Conesa, Maria; Yago Martinez Varela, Ignacio; Victoriano Baez Pravia, Orville; Cruz Martin Delgado, Maria; Munoz de Cabo, Carlos; Ioan, Ana-Maria; Perez-Calvo, Cesar; Santos, Arnoldo; Abad-Motos, Ane; Ripolles-Melchor, Javier; Civantos Martin, Belén; Yus Teruel, Santiago; Higuera Lucas, Juan; Blandino Ortiz, Aaron; de Pablo Sánchez, Raúl; Emilio Barrueco-Francioni, Jesús; Forcelledo Espina, Lorena; Bonell-Goytisolo, José M.; Salaverria, Iñigo; Socias Mir, Antonia; Rodriguez-Ruiz, Emilio; Hidalgo Valverde, Virginia; Jimeno Cubero, Patricia; Arbol Linde, Francisca; Cruza Leganes, Nieves; Maria Romeu, Juan; Concha, Pablo; Angel Berezo-Garcia, José; Fraile, Virginia; Cuenca-Rubio, Cristina; Pérez-Torres, David; Serrano, Ainhoa; Martínez Valero, Clara; Ortiz Suner, Andrea; Larrañaga, Leire; Legaristi, Noemi; Ferrigno, Gerardo; Khlafalla, Safa; Bihariesingh-Sanchit, Rosita; Sjukhus, Hallands; Zoerner, Frank; Grip, Jonathan; Kilsand, Kristina; Mårtensson, Johan; Österlind, Jonas; Sjukhuset, Akademiska; von Seth, Magnus; Sjukhus, Västerviks; Berkius, Johan; Ceruti, Samuele; Glotta, Andrea; Izdes, Seval; Özkoçak Turan, Işıl; Cosar, Ahmet; Halacli, Burcin; Dereli, Necla; Yilmaz, Mehmet; Akbas, Türkay; Elay, Gülseren; Eyüpoğlu, Selin; Bílír, Yelíz; Tolga Saraçoğlu, Kemal; Kaya, Ebru; Sultan Sahin, Ayca; Korkmaz Ekren, Pervin; Mengi, Tuğçe; Ozmen Suner, Kezban; Tomak, Yakup; Eroglu, Ahmet; Alsabbah, Asad; Hanlon, Katie; Gervin, Kevin; Mcmahon, Sean; Hagan, Samantha; Higenbottam, Caroline V.; Mullhi, Randeep; Poulton, Lottie; Torlinski, Tomasz; Gareth, Allen; Truman, Nick; Vijayakumar, Gopal; Hall, Chris; Jubb, Alasdair; Cagova, Lenka; Jones, Nicola; Graham, Sam; Robin, Nicole; Cowton, Amanda; Donnelly, Adrian; Singatullina, Natalia; Kent, Melanie; Boulanger, Carole; Campbell, Zoë; Potter, Elizabeth; Duric, Natalie; Szakmany, Tamas; Brompton, Royal; Kviatkovske, Orinta; Marczin, Nandor; Ellis, Caroline; Saha, Rajnish; Sri-Chandana, Chunda; Allan, John; Mumelj, Lana; Venkatesh, Harish; Nina Gotz, Vera; Cochrane, Anthony; Ficial, Barbara; Kamble, Shruthi; Lumlertgul, Nuttha; Oddy, Christopher; Jain, Susan; Beatrice Crapelli, Giulia; Vlachou, Aikaterini; Golden, David; Garrioch, Sweyn; Henning, Jeremy; Loveleena, Gupta; Davey, Miriam; Grauslyte, Lina; Salciute-Simene, Erika; Cook, Martin; Barling, Danny; Broadhurst, Phil; Purvis, Sarah; Spivey, Michael; Shuker, Benjamin; Grecu, Irina; Harding, Daniel; Singatullina, Natalia; Dean, James T.; Nielsen, Nathan D.; Al-Bayati, Sama; Al-Sadawi, Mohammed; Charron, Mariane; Stubenrauch, Peter; Santanilla, Jairo; Wentowski, Catherine; Rosenberger, Dorothea; Eksarko, Polikseni; Randeep Jawa, And
Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study / Massimiliano, Greco; Thomas, De Corte; Ari, Ercole; Massimo, Antonelli; Elie, Azoulay; Giuseppe, Citerio; Andy Conway, Morris; Gennaro, De Pascale; Frantisek, Duska; Paul, Elbers; Sharon, Einav; Lui, Forni; Laura, Galarza; Armand R J, Girbes; Giacomo, Grasselli; Vitaly, Gusarov; Alasdair, Jubb; Jozef, Kesecioglu; Andrea, Lavinio; Maria Cruz Martin, Delgado; Johannes, Mellinghoff; Sheila Nainan, Myatra; Marlies, Ostermann; Mariangela, Pellegrini; Pedro, Povoa; Stefan J, Schaller; Jean-Louis, Teboul; Adrian, Wong; Jan J, De Waele; Maurizio, Cecconi; Bezzi, Marco; Gira, Alicia; Eller, Philipp; Hamid, Tarikul; Ull Haque, Injamam; De Buyser, Wim; Cudia, Antonella; De Backer, Daniel; Foulon, Pierre; Collin, Vincent; De Waele, Jan; Van Hecke, Jolien; De Waele, Elisabeth; Van Malderen, Claire; Mesland, Jean-Baptiste; Biston, Patrick; Piagnerelli, Michael; Haentjens, Lionel; De Schryver, Nicolas; Van Leemput, Jan; Vanhove, Philippe; Bulpa, Pierre; Ilieva, Viktoria; Katz, David; Binnie, Alexandra; Geagea, Anna; Tirapegui, Fernando; Lago, Gustavo; Graf, Jerónimo; Perez-Araos, Rodrigo; Vargas, Patricio; Martinez, Felipe; Labarca, Eduardo; Molano Franco, Daniel; Parra-Tanoux, Daniela; Felipe Reyes, Luis; Yepes, David; Periš, Filip; Stojanović Stipić, Sanda; Vanessa Campozano Burgos, Cynthia; Roberto Navas Boada, Paulo; Luis Barberan Brun, Jose; Pablo Paredes Ballesteros, Juan; Abdelnasser, Gamal; Hammouda, Ahmed; Elmandouh, Omar; Azzam, Ahmed; Mohamed Hussein, Aliae; Galal, Islam; Awad, Ahmed K.; Azab, Mohammed A.; Abdalla, Maged; Assal, Hebatallah; Alfishawy, Mostafa; Ghozy, Sherief; Tharwat, Samar; Eldaly, Abdullah; Ellervee, Anneli; Reinhard, Veronika; Chrisment, Anne; Poyat, Chrystelle; Badie, Julio; Berdaguer Ferrari, Fernando; Weiss, Björn; Schellenberg, Clara; Grunow, Julius J.; Lorenz, Marco; Schaller, Stefan J.; Spieth, Peter; Bota, Marc; Fichtner, Falk; Fuest, Kristina; Lahmer, Tobias; Herrmann, Johannes; Meybohm, Patrick; Markou, Nikolaos; Vasileiadou, Georgia; Chrysanthopoulou, Evangelia; Papamichalis, Panagiotis; Soultati, Ioanna; Jog, Sameer; Kalvit, Kushal; Nainan Myatra, Sheila; Krupa, Ivan; Tharwat, Aisa; Nichol, Alistair; Mccarthy, Aine; Mahmoodpoor, Ata; Tonetti, Tommaso; Isoni, Paolo; Spadaro, Savino; Alberto Volta, Carlo; Mirabella, Lucia; Noto, Alberto; Florio, Gaetano; Guzzardella, Amedeo; Paleari, Chiara; Baccanelli, Federica; Savi, Marzia; Antonelli, Massimo; De Pascale, Gennaro; Luca, San; Vaccarini, Barbara; Montrucchio, Giorgia; Sales, Gabriele; Donadello, Katia; Gottin, Leonardo; Nizzero, Marta; Polati, Enrico; De Rosa, Silvia; Sulemanji, Demet; Abusalama, Abdurraouf; Elhadi, Muhammed; De FelipeJesus, Montelongo; Rodriguez Gonzalez, Daniel; Hugo Madrigal Robles, Victor; Canedo, Nancy; Esquivel Chavez, Alejandro; Dendane, Tarek; Grady, Bart; de Jong, Ben; van der Heiden, Eveline; Thoral, Patrick; van den Bogaard, Bas; Spronk, Peter E.; Achterberg, Sefanja; Groeneveld, Melanie; So, Ralph K. L.; de Wijs, Calvin; Scholten, Harm; Beishuizen, Albertus; Cornet, Alexander D.; Reidinga, Auke C.; Kranen, Hetty; Mensink, Roos; Gasthuis, Spaarne; den Boer, Sylvia; de Groot, Marcel; Beck, Oliver; Bethlehem, Carina; van Bussel, Bas; Frenzel, Tim; de Jong, Celestine; Wilting, Rob; Kesecioglu, Jozef; Mehagnoul-Schipper, Jannet; Alasia, Datonye; Kumar, Ashok; Qayyum, Ahad; Rana, Muhammad; Abu Jayyab, Mustafa; Quispe Sierra, Rosario; Mark Hernandez, Aaron; de Almeida, José; Taborda, Lúcia; Anselmo, Mónica; Ramires, Tiago; Silva, Catarina; Roriz, Carolina; Morais, Rui; Póvoa, Pedro; Patricio, Patricia; Pinto, André; Lurdes Santos, Maria; Costa, Vasco; Cunha, Pedro; Gonçalves, Celina; Nunes, Sandra; Camões, João; Adrião, Diana; Oliveira, Ana; Omrani, Ali; Al Maslamani, Muna; Suei elbuzidi, Abdurrahmaan; Mahmoud Al qudah, Bara; Rauof Akkari, Abdel; Alkhatteb, Mohamed; Baiou, Anas; Husain, Ahmed; Alwraidat, Mohamed; Abdulsalam Saif, Ibrahim; Bakdach, Dana; Ahmed, Amna; Aleef, Mohamed; Bintaher, Awadh; Petrisor, Cristina; Popov, Evgeniy; Popova, Ksenia; Dementienko, Mariia; Teplykh, Boris; Pyregov, Alexey; Davydova, Liubov; Vladislav, Belskii; Neporada, Elena; Zverev, Ivan; Meshchaninova, Svetlana; Sokolov, Dmitry; Gavrilova, Elena; Shlyk, Irina; Poliakov, Igor; Vlasova, Marina; Aljuhani, Ohoud; Alkhalaf, Amina; Bin Humaid, Felwa; Arabi, Yaseen; Kuhail, Ahmed; Elrabi, Omar; Ghannam, Madihah E.; Teng Fong, Ng; Kansal, Amit; Kian Ho, Vui; Ng, Jensen; Rodrígez García, Raquel; Taboada Fraga, Xiana; del Pilar García-Bonillo, Mª; Padilla-Serrano, Antonio; Martin Cuadrado, Marta; Ferrando, Carlos; Catalan-Monzon, Ignacio; Galarza, Laura; Frutos-Vivar, Fernando; Jimenez, Jorge; Rodríguez-Solis, Carmen; Franquesa-Gonzalez, Enric; Pérez Acosta, Guillermo; Santana Cabrera, Luciano; Pablo Aviles Parra, Juan; Muñoyerro Gonzalez, Francisco; del Carmen Lorente Conesa, Maria; Yago Martinez Varela, Ignacio; Victoriano Baez Pravia, Orville; Cruz Martin Delgado, Maria; Munoz de Cabo, Carlos; Ioan, Ana-Maria; Perez-Calvo, Cesar; Santos, Arnoldo; Abad-Motos, Ane; Ripolles-Melchor, Javier; Civantos Martin, Belén; Yus Teruel, Santiago; Higuera Lucas, Juan; Blandino Ortiz, Aaron; de Pablo Sánchez, Raúl; Emilio Barrueco-Francioni, Jesús; Forcelledo Espina, Lorena; Bonell-Goytisolo, José M.; Salaverria, Iñigo; Socias Mir, Antonia; Rodriguez-Ruiz, Emilio; Hidalgo Valverde, Virginia; Jimeno Cubero, Patricia; Arbol Linde, Francisca; Cruza Leganes, Nieves; Maria Romeu, Juan; Concha, Pablo; Angel Berezo-Garcia, José; Fraile, Virginia; Cuenca-Rubio, Cristina; Pérez-Torres, David; Serrano, Ainhoa; Martínez Valero, Clara; Ortiz Suner, Andrea; Larrañaga, Leire; Legaristi, Noemi; Ferrigno, Gerardo; Khlafalla, Safa; Bihariesingh-Sanchit, Rosita; Sjukhus, Hallands; Zoerner, Frank; Grip, Jonathan; Kilsand, Kristina; Mårtensson, Johan; Österlind, Jonas; Sjukhuset, Akademiska; von Seth, Magnus; Sjukhus, Västerviks; Berkius, Johan; Ceruti, Samuele; Glotta, Andrea; Izdes, Seval; Özkoçak Turan, Işıl; Cosar, Ahmet; Halacli, Burcin; Dereli, Necla; Yilmaz, Mehmet; Akbas, Türkay; Elay, Gülseren; Eyüpoğlu, Selin; Bílír, Yelíz; Tolga Saraçoğlu, Kemal; Kaya, Ebru; Sultan Sahin, Ayca; Korkmaz Ekren, Pervin; Mengi, Tuğçe; Ozmen Suner, Kezban; Tomak, Yakup; Eroglu, Ahmet; Alsabbah, Asad; Hanlon, Katie; Gervin, Kevin; Mcmahon, Sean; Hagan, Samantha; Higenbottam, Caroline V.; Mullhi, Randeep; Poulton, Lottie; Torlinski, Tomasz; Gareth, Allen; Truman, Nick; Vijayakumar, Gopal; Hall, Chris; Jubb, Alasdair; Cagova, Lenka; Jones, Nicola; Graham, Sam; Robin, Nicole; Cowton, Amanda; Donnelly, Adrian; Singatullina, Natalia; Kent, Melanie; Boulanger, Carole; Campbell, Zoë; Potter, Elizabeth; Duric, Natalie; Szakmany, Tamas; Brompton, Royal; Kviatkovske, Orinta; Marczin, Nandor; Ellis, Caroline; Saha, Rajnish; Sri-Chandana, Chunda; Allan, John; Mumelj, Lana; Venkatesh, Harish; Nina Gotz, Vera; Cochrane, Anthony; Ficial, Barbara; Kamble, Shruthi; Lumlertgul, Nuttha; Oddy, Christopher; Jain, Susan; Beatrice Crapelli, Giulia; Vlachou, Aikaterini; Golden, David; Garrioch, Sweyn; Henning, Jeremy; Loveleena, Gupta; Davey, Miriam; Grauslyte, Lina; Salciute-Simene, Erika; Cook, Martin; Barling, Danny; Broadhurst, Phil; Purvis, Sarah; Spivey, Michael; Shuker, Benjamin; Grecu, Irina; Harding, Daniel; Singatullina, Natalia; Dean, James T.; Nielsen, Nathan D.; Al-Bayati, Sama; Al-Sadawi, Mohammed; Charron, Mariane; Stubenrauch, Peter; Santanilla, Jairo; Wentowski, Catherine; Rosenberger, Dorothea; Eksarko, Polikseni; Randeep Jawa, And. - In: INTENSIVE CARE MEDICINE. - ISSN 0342-4642. - 48:6(2022), pp. 690-705. [10.1007/s00134-022-06705-1]
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