Background and purpose: Grey matter (GM) atrophy is present from the earliest stages of multiple sclerosis (MS) and occurs largely in a nonrandom manner. However, the biological mechanisms underlying the progression of regional atrophy are still unclear. Aim of this study is to investigate whether amyloid pathology might be involved in determining the pattern of GM atrophy over time. Methods: Forty-six subjects were recruited: 31 newly diagnosed relapsing-remitting (RR-) MS patients and 15 age- and sex-matched healthy controls (HC). Aβ levels were determined in CSF samples from all subjects. All participants underwent brain magnetic resonance imaging (MRI) at baseline, and 23 out of 31 patients at one year follow-up. T1-weighted scans were segmented using the Geodesic Information Flows software. Non-parametric statistical tests were used for between-group comparisons and multiple regression analyses. Results: CSF Aβ concentration was the best predictor of global GM loss over time after age (β = 0.403; p = 0.024), in particular in the left precuneus (p = 0.045), in the left middle cingulate gyrus (p = 0.009), in the left precentral gyrus (p = 0.021) and in the right angular gyrus (p = 0.029). Conclusions: CSF Aβ levels seem to be crucial in MS early brain volume loss as GM atrophy manifests in regions particularly vulnerable to early Aβ deposition.

Low CSF β-amyloid levels predict early regional grey matter atrophy in multiple sclerosis / Pietroboni, A. M.; Colombi, A.; Carandini, T.; Contarino, V. E.; Ghezzi, L.; Fumagalli, G. G.; Arighi, A.; Fenoglio, C.; De Riz, M. A.; Triulzi, F.; Scarpini, E.; Galimberti, D.. - In: MULTIPLE SCLEROSIS AND RELATED DISORDERS. - ISSN 2211-0348. - 39:(2020), pp. 1018991-1018997. [10.1016/j.msard.2019.101899]

Low CSF β-amyloid levels predict early regional grey matter atrophy in multiple sclerosis

Fumagalli G. G.;
2020-01-01

Abstract

Background and purpose: Grey matter (GM) atrophy is present from the earliest stages of multiple sclerosis (MS) and occurs largely in a nonrandom manner. However, the biological mechanisms underlying the progression of regional atrophy are still unclear. Aim of this study is to investigate whether amyloid pathology might be involved in determining the pattern of GM atrophy over time. Methods: Forty-six subjects were recruited: 31 newly diagnosed relapsing-remitting (RR-) MS patients and 15 age- and sex-matched healthy controls (HC). Aβ levels were determined in CSF samples from all subjects. All participants underwent brain magnetic resonance imaging (MRI) at baseline, and 23 out of 31 patients at one year follow-up. T1-weighted scans were segmented using the Geodesic Information Flows software. Non-parametric statistical tests were used for between-group comparisons and multiple regression analyses. Results: CSF Aβ concentration was the best predictor of global GM loss over time after age (β = 0.403; p = 0.024), in particular in the left precuneus (p = 0.045), in the left middle cingulate gyrus (p = 0.009), in the left precentral gyrus (p = 0.021) and in the right angular gyrus (p = 0.029). Conclusions: CSF Aβ levels seem to be crucial in MS early brain volume loss as GM atrophy manifests in regions particularly vulnerable to early Aβ deposition.
2020
Pietroboni, A. M.; Colombi, A.; Carandini, T.; Contarino, V. E.; Ghezzi, L.; Fumagalli, G. G.; Arighi, A.; Fenoglio, C.; De Riz, M. A.; Triulzi, F.; Scarpini, E.; Galimberti, D.
Low CSF β-amyloid levels predict early regional grey matter atrophy in multiple sclerosis / Pietroboni, A. M.; Colombi, A.; Carandini, T.; Contarino, V. E.; Ghezzi, L.; Fumagalli, G. G.; Arighi, A.; Fenoglio, C.; De Riz, M. A.; Triulzi, F.; Scarpini, E.; Galimberti, D.. - In: MULTIPLE SCLEROSIS AND RELATED DISORDERS. - ISSN 2211-0348. - 39:(2020), pp. 1018991-1018997. [10.1016/j.msard.2019.101899]
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S2211034819309708-main.pdf

Solo gestori archivio

Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.4 MB
Formato Adobe PDF
1.4 MB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/355778
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 4
social impact