Herein, we performed a gene expression profiling in a cohort of 10 mild cognitive impairment (MCI), subdivided, according to the analysis of cerebrospinal fluid biomarkers, in prodromal Alzheimer's disease (AD) and non-AD MCI, as compared with 27 AD patients and 24 controls, in order to detect early gene expression alterations. We observed a significant upregulation of insulin (INS) and INS Receptor (INSR) expression levels in AD both prodromal and fully symptomatic, as compared with controls, but not in MCI subjects. Our results suggest an early dysregulation of INS and INSR in AD pathogenesis and pave the way to a possible utility of these transcripts as peripheral biomarkers.

Profiling of specific gene expression pathways in peripheral cells from prodromal Alzheimer's disease patients / Serpente, M.; Fenoglio, C.; Cioffi, S. M. G.; Oldoni, E.; Arcaro, M.; Arighi, A.; Fumagalli, G. G.; Ghezzi, L.; Scarpini, E.; Galimberti, D.. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 61:4(2018), pp. 1289-1294. [10.3233/JAD-170861]

Profiling of specific gene expression pathways in peripheral cells from prodromal Alzheimer's disease patients

Fumagalli G. G.;
2018-01-01

Abstract

Herein, we performed a gene expression profiling in a cohort of 10 mild cognitive impairment (MCI), subdivided, according to the analysis of cerebrospinal fluid biomarkers, in prodromal Alzheimer's disease (AD) and non-AD MCI, as compared with 27 AD patients and 24 controls, in order to detect early gene expression alterations. We observed a significant upregulation of insulin (INS) and INS Receptor (INSR) expression levels in AD both prodromal and fully symptomatic, as compared with controls, but not in MCI subjects. Our results suggest an early dysregulation of INS and INSR in AD pathogenesis and pave the way to a possible utility of these transcripts as peripheral biomarkers.
2018
4
Serpente, M.; Fenoglio, C.; Cioffi, S. M. G.; Oldoni, E.; Arcaro, M.; Arighi, A.; Fumagalli, G. G.; Ghezzi, L.; Scarpini, E.; Galimberti, D.
Profiling of specific gene expression pathways in peripheral cells from prodromal Alzheimer's disease patients / Serpente, M.; Fenoglio, C.; Cioffi, S. M. G.; Oldoni, E.; Arcaro, M.; Arighi, A.; Fumagalli, G. G.; Ghezzi, L.; Scarpini, E.; Galimberti, D.. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 61:4(2018), pp. 1289-1294. [10.3233/JAD-170861]
File in questo prodotto:
File Dimensione Formato  
2018 Serpente et al.pdf

Solo gestori archivio

Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 442.32 kB
Formato Adobe PDF
442.32 kB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/355723
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
  • OpenAlex ND
social impact