Purpose: Positron emission tomography (PET) with amyloid tracers (amy-PET) allows the quantification of pathological amyloid deposition in the brain tissues, including the white matter (WM). Here, we evaluate amy-PET uptake in WM lesions (WML) and in the normal-appearing WM (NAWM) of patients with Alzheimer’s disease (AD) and non-AD type of dementia. Methods: Thirty-three cognitively impaired subjects underwent brain magnetic resonance imaging (MRI), Aβ1-42 (Aβ) determination in the cerebrospinal fluid (CSF) and amy-PET. Twenty-three patients exhibiting concordant results in both CSF analysis and amy-PET for cortical amyloid deposition were recruited and divided into two groups, amyloid positive (A+) and negative (A−). WML quantification and brain volumes’ segmentation were performed. Standardized uptake values ratios (SUVR) were calculated in the grey matter (GM), NAWM and WML on amy-PET coregistered to MRI images. Results: A+ compared to A− showed a higher WML load (p = 0.049) alongside higher SUVR in all brain tissues (p < 0.01). No correlations between CSF Aβ levels and WML and NAWM SUVR were found in A+, while, in A−, CSF Aβ levels were directly correlated to NAWM SUVR (p = 0.04). CSF Aβ concentration was the only predictor of NAWM SUVR (adj R2 = 0.91; p = 0.04) in A−. In A+ but not in A− direct correlations were identified between WM and GM SUVR (p < 0.01). Conclusions: Our data provide evidence on the role of amy-PET in the assessment of microstructural WM injury in non-AD dementia, whereas amy-PET seems less suitable to assess WM damage in AD patients due to a plausible amyloid accrual therein.

Amyloid PET imaging and dementias: potential applications in detecting and quantifying early white matter damage / Pietroboni, A. M.; Colombi, A.; Carandini, T.; Sacchi, L.; Fenoglio, C.; Marotta, G.; Arighi, A.; De Riz, M. A.; Fumagalli, G. G.; Castellani, M.; Bozzali, M.; Scarpini, E.; Galimberti, D.. - In: ALZHEIMER'S RESEARCH & THERAPY. - ISSN 1758-9193. - 14:1(2022), pp. 331-338. [10.1186/s13195-021-00933-1]

Amyloid PET imaging and dementias: potential applications in detecting and quantifying early white matter damage

Fumagalli G. G.;
2022-01-01

Abstract

Purpose: Positron emission tomography (PET) with amyloid tracers (amy-PET) allows the quantification of pathological amyloid deposition in the brain tissues, including the white matter (WM). Here, we evaluate amy-PET uptake in WM lesions (WML) and in the normal-appearing WM (NAWM) of patients with Alzheimer’s disease (AD) and non-AD type of dementia. Methods: Thirty-three cognitively impaired subjects underwent brain magnetic resonance imaging (MRI), Aβ1-42 (Aβ) determination in the cerebrospinal fluid (CSF) and amy-PET. Twenty-three patients exhibiting concordant results in both CSF analysis and amy-PET for cortical amyloid deposition were recruited and divided into two groups, amyloid positive (A+) and negative (A−). WML quantification and brain volumes’ segmentation were performed. Standardized uptake values ratios (SUVR) were calculated in the grey matter (GM), NAWM and WML on amy-PET coregistered to MRI images. Results: A+ compared to A− showed a higher WML load (p = 0.049) alongside higher SUVR in all brain tissues (p < 0.01). No correlations between CSF Aβ levels and WML and NAWM SUVR were found in A+, while, in A−, CSF Aβ levels were directly correlated to NAWM SUVR (p = 0.04). CSF Aβ concentration was the only predictor of NAWM SUVR (adj R2 = 0.91; p = 0.04) in A−. In A+ but not in A− direct correlations were identified between WM and GM SUVR (p < 0.01). Conclusions: Our data provide evidence on the role of amy-PET in the assessment of microstructural WM injury in non-AD dementia, whereas amy-PET seems less suitable to assess WM damage in AD patients due to a plausible amyloid accrual therein.
2022
1
Pietroboni, A. M.; Colombi, A.; Carandini, T.; Sacchi, L.; Fenoglio, C.; Marotta, G.; Arighi, A.; De Riz, M. A.; Fumagalli, G. G.; Castellani, M.; Bozzali, M.; Scarpini, E.; Galimberti, D.
Amyloid PET imaging and dementias: potential applications in detecting and quantifying early white matter damage / Pietroboni, A. M.; Colombi, A.; Carandini, T.; Sacchi, L.; Fenoglio, C.; Marotta, G.; Arighi, A.; De Riz, M. A.; Fumagalli, G. G.; Castellani, M.; Bozzali, M.; Scarpini, E.; Galimberti, D.. - In: ALZHEIMER'S RESEARCH & THERAPY. - ISSN 1758-9193. - 14:1(2022), pp. 331-338. [10.1186/s13195-021-00933-1]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/355698
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