Long-term sequelae of symptomatic infection caused by SARS-CoV-2 are largely undiscovered. We performed a prospective cohort study on consecutively hospitalized Sars-CoV-2 patients (March-May 2020) for evaluating COVID-19 outcomes at 6 and 12 months. After hospital discharge, patients were addressed to two follow-up pathways based on respiratory support needed during hospitalization. Outcomes were assessed by telephone consultation or ambulatory visit. Among 471 patients, 80.9% received no respiratory support during hospitalization; 19.1% received non-invasive ventilation (NIV) or invasive mechanical ventilation (IMV). 58 patients died during hospitalization, therefore 413 were enrolled for follow-up. At 6 months, among 355 patients, the 30.3% had any symptoms, 18.0% dyspnea, 6.2% neurological symptoms. Fifty-two out of 105 had major damages in interstitial computed tomography images. NIV/IMV patients had higher probability to suffer of symptoms (aOR = 4.00, 95%CI:1.99-8.05), dyspnea (aOR = 2.80, 95%CI:1.28-6.16), neurological symptoms (aOR = 9.72, 95%CI:2.78-34.00). At 12 months, among 344, the 25.3% suffered on any symptoms, 12.2% dyspnea, 10.1% neurological symptoms. Severe interstitial lesions were present in 37 out of 47 investigated patients. NIV/IMV patients in respect to no respiratory support, had higher probability of experiencing symptoms (aOR = 3.66, 95%CI:1.73-7.74), neurological symptoms (aOR = 8.96, 95%CI:3.22-24.90). COVID-19 patients showed prolonged sequelae up to 12 months, highlighting the need of follow-up pathways for post-COVID-19 syndrome.

"Long COVID" results after hospitalization for SARS-CoV-2 infection / Rigoni, Marta; Torri, Emanuele; Nollo, Giandomenico; Donne, Livia Delle; Rizzardo, Sebastiano; Lenzi, Lorenza; Falzone, Andrea; Cozzio, Susanna. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 12:1(2022), p. 9581. [10.1038/s41598-022-13077-5]

"Long COVID" results after hospitalization for SARS-CoV-2 infection

Rigoni, Marta;Torri, Emanuele;Nollo, Giandomenico;Cozzio, Susanna
2022-01-01

Abstract

Long-term sequelae of symptomatic infection caused by SARS-CoV-2 are largely undiscovered. We performed a prospective cohort study on consecutively hospitalized Sars-CoV-2 patients (March-May 2020) for evaluating COVID-19 outcomes at 6 and 12 months. After hospital discharge, patients were addressed to two follow-up pathways based on respiratory support needed during hospitalization. Outcomes were assessed by telephone consultation or ambulatory visit. Among 471 patients, 80.9% received no respiratory support during hospitalization; 19.1% received non-invasive ventilation (NIV) or invasive mechanical ventilation (IMV). 58 patients died during hospitalization, therefore 413 were enrolled for follow-up. At 6 months, among 355 patients, the 30.3% had any symptoms, 18.0% dyspnea, 6.2% neurological symptoms. Fifty-two out of 105 had major damages in interstitial computed tomography images. NIV/IMV patients had higher probability to suffer of symptoms (aOR = 4.00, 95%CI:1.99-8.05), dyspnea (aOR = 2.80, 95%CI:1.28-6.16), neurological symptoms (aOR = 9.72, 95%CI:2.78-34.00). At 12 months, among 344, the 25.3% suffered on any symptoms, 12.2% dyspnea, 10.1% neurological symptoms. Severe interstitial lesions were present in 37 out of 47 investigated patients. NIV/IMV patients in respect to no respiratory support, had higher probability of experiencing symptoms (aOR = 3.66, 95%CI:1.73-7.74), neurological symptoms (aOR = 8.96, 95%CI:3.22-24.90). COVID-19 patients showed prolonged sequelae up to 12 months, highlighting the need of follow-up pathways for post-COVID-19 syndrome.
2022
1
Rigoni, Marta; Torri, Emanuele; Nollo, Giandomenico; Donne, Livia Delle; Rizzardo, Sebastiano; Lenzi, Lorenza; Falzone, Andrea; Cozzio, Susanna...espandi
"Long COVID" results after hospitalization for SARS-CoV-2 infection / Rigoni, Marta; Torri, Emanuele; Nollo, Giandomenico; Donne, Livia Delle; Rizzardo, Sebastiano; Lenzi, Lorenza; Falzone, Andrea; Cozzio, Susanna. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 12:1(2022), p. 9581. [10.1038/s41598-022-13077-5]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/355623
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