Alzheimer's disease (AD) is the most common form of dementia among the elderly. Research in the AD field has been mostly focused on the biology of the Aβ peptide but increasing evidence is shifting attention toward the physiological role of APP as key to understanding AD pathology. It is becoming apparent that APP plays a central role in the mechanisms that guarantee the accuracy and the robustness of brain wiring. In the present review we explore APP functions with focus on some of the underlying molecular mechanisms.

Beyond pathology: APP, brain development and Alzheimer's disease / Soldano, Alessia; Hassan, Bassem A. - In: CURRENT OPINION IN NEUROBIOLOGY. - ISSN 0959-4388. - 27:(2014), pp. 61-67. [10.1016/j.conb.2014.02.003]

Beyond pathology: APP, brain development and Alzheimer's disease

Soldano, Alessia;
2014-01-01

Abstract

Alzheimer's disease (AD) is the most common form of dementia among the elderly. Research in the AD field has been mostly focused on the biology of the Aβ peptide but increasing evidence is shifting attention toward the physiological role of APP as key to understanding AD pathology. It is becoming apparent that APP plays a central role in the mechanisms that guarantee the accuracy and the robustness of brain wiring. In the present review we explore APP functions with focus on some of the underlying molecular mechanisms.
2014
Soldano, Alessia; Hassan, Bassem A
Beyond pathology: APP, brain development and Alzheimer's disease / Soldano, Alessia; Hassan, Bassem A. - In: CURRENT OPINION IN NEUROBIOLOGY. - ISSN 0959-4388. - 27:(2014), pp. 61-67. [10.1016/j.conb.2014.02.003]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/351762
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 38
  • ???jsp.display-item.citation.isi??? 36
social impact