Brain tumors are a large and heterogeneous group of neoplasms that affect the central nervous system and include some of the deadliest cancers. Almost all the conventional and new treatments fail to hinder tumoral growth of the most malignant brain tumors. This is due to multiple factors, such as intra-tumor heterogeneity, the microenvironmental properties of the human brain, and the lack of reliable models to test new therapies. Therefore, creating faithful models for each tumor and discovering tailored treatments pose great challenges in the fight against brain cancer. Over the years, different types of models have been generated, and, in this review, we investigated the advantages and disadvantages of the models currently used

Modeling Brain Tumors: A Perspective Overview of in vivo and Organoid Models / Antonica, Francesco; Aiello, Giuseppe; Soldano, Alessia; Abballe, Luana; Miele, Evelina; Tiberi, Luca. - In: FRONTIERS IN MOLECULAR NEUROSCIENCE. - ISSN 1662-5099. - 2022, 15:(2022), pp. 818696.1-818696.19. [10.3389/fnmol.2022.818696]

Modeling Brain Tumors: A Perspective Overview of in vivo and Organoid Models

Antonica, Francesco;Aiello, Giuseppe;Soldano, Alessia;Tiberi, Luca
2022

Abstract

Brain tumors are a large and heterogeneous group of neoplasms that affect the central nervous system and include some of the deadliest cancers. Almost all the conventional and new treatments fail to hinder tumoral growth of the most malignant brain tumors. This is due to multiple factors, such as intra-tumor heterogeneity, the microenvironmental properties of the human brain, and the lack of reliable models to test new therapies. Therefore, creating faithful models for each tumor and discovering tailored treatments pose great challenges in the fight against brain cancer. Over the years, different types of models have been generated, and, in this review, we investigated the advantages and disadvantages of the models currently used
Antonica, Francesco; Aiello, Giuseppe; Soldano, Alessia; Abballe, Luana; Miele, Evelina; Tiberi, Luca
Modeling Brain Tumors: A Perspective Overview of in vivo and Organoid Models / Antonica, Francesco; Aiello, Giuseppe; Soldano, Alessia; Abballe, Luana; Miele, Evelina; Tiberi, Luca. - In: FRONTIERS IN MOLECULAR NEUROSCIENCE. - ISSN 1662-5099. - 2022, 15:(2022), pp. 818696.1-818696.19. [10.3389/fnmol.2022.818696]
File in questo prodotto:
File Dimensione Formato  
fnmol-15-818696 (11).pdf

accesso aperto

Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Creative commons
Dimensione 3.39 MB
Formato Adobe PDF
3.39 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11572/351740
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact