[The full abstract is available to authorized users only in the full text of the thesis.] Duchenne muscular dystrophy (DMD) is the most common inherited muscle disease of childhood. Although under normal conditions muscle stem cells present a very powerful regenerative response, the regenerative potential is progressively lost in patients affected by DMD and fibrotic tissue progressively replaces muscle fibers leading to an impairment of muscle function. Elevated Wnt-signaling has been shown to play a detrimental role in the regenerative process and promotes the accumulation of fibrotic tissue in dystrophic muscles. However, the molecular and cellular pathways responsible for this process are poorly characterized. [...] By increasing the comprehension of the link existing between the complement system and degenerative diseases like DMD the findings presented here will contribute to open to the definition of novel therapeutic strategies to investigate in the clinical setting.

Insight into the role of complement C1/WNT axis in dystrophic muscles / Florio, Francesca. - (2022 Apr 20), pp. 1-134. [10.15168/11572_338532]

Insight into the role of complement C1/WNT axis in dystrophic muscles.

Florio, Francesca
2022-04-20

Abstract

[The full abstract is available to authorized users only in the full text of the thesis.] Duchenne muscular dystrophy (DMD) is the most common inherited muscle disease of childhood. Although under normal conditions muscle stem cells present a very powerful regenerative response, the regenerative potential is progressively lost in patients affected by DMD and fibrotic tissue progressively replaces muscle fibers leading to an impairment of muscle function. Elevated Wnt-signaling has been shown to play a detrimental role in the regenerative process and promotes the accumulation of fibrotic tissue in dystrophic muscles. However, the molecular and cellular pathways responsible for this process are poorly characterized. [...] By increasing the comprehension of the link existing between the complement system and degenerative diseases like DMD the findings presented here will contribute to open to the definition of novel therapeutic strategies to investigate in the clinical setting.
XXXIII
2019-2020
CIBIO (29/10/12-)
Biomolecular Sciences
Conti, Luciano
Biressi, Stefano Augusto Maria
no
Inglese
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Descrizione: Tesi di dottorato di Francesca Florio
Tipologia: Tesi di dottorato (Doctoral Thesis)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11572/338532
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