08 Tesi di dottorato (Doctoral Thesis)

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08.1 Tesi di dottorato (Doctoral Thesis) 2802

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Design and synthesis of small molecules as inhibitors of YTHDF proteins

In this work, I designed and synthesized two different classes of compounds capable of binding to the YTH domain of the YTHDF1-3 proteins. The first class of inhibitors includes ebselen analogs, an organoselenium compound that emerged as the top hit from a high-throughput screening of an in-house compound library; the second class is derived from a computational study. The YTHDF1-3 reader proteins are a class of three highly conserved paralogs that selectively recognize and bind the m6A modif...

Morphodynamics of multi-thread rivers Theory and Observations of Channel Loops

Using satellite and aerial imagery, the planform of a large number of bifurcations is gathered and interpreted in terms of quantifiable parameters. The majority of the observed bifurcations displays a conspicuous asymmetry in terms of bifurcation angle, upstream channel curvature, length of the downstream bifurcates. The first part of this work focuses on the effect of the differences in channel width between the upstream channel and the bifurcates added together and between the bifurcat...

Intelligent System for the Classification of Mental State Parameters

Mental health is essential for overall well-being, focusing emotional, psychological, and social aspects. Assessing and managing mental health requires understanding mental state parameters, including cognitive load, cognitive impairment, and emotional state. Advanced technologies like eye tracking provide valuable insights into these parameters, transformed mental health evaluation and enabled more targeted interventions and better outcomes. Thesis focused towards developing intelligent sy...

c-Myc dysregulation contributes to the glia-to-neuron miscommunication in Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a non-cell-autonomous disease. In early 2000, seminal and concordant studies demonstrated that glia modulates disease progression in a mouse model expressing a mutant form of SOD1. This effect has not been validated yet in a transgenic mouse expressing TDP-43Q331K, so we selectively deleted the transgenic TDP-43 in astrocytes and observed an improvement of motor symptoms and a rescue of the cognitive impairment. We performed RNA sequencing of astrocytes ...

Emotional Prosody across languages and genders

This dissertation investigates emotional prosody across different languages and gen- ders, with a focus on its role in the development of Automatic Speech Emotion Recogni- tion (ASER) systems. Recognizing the limitations of existing emotional speech datasets, such as their narrow scope, limited number of speakers, and languages, this work intro- duces the Actors Challenge (AC) dataset. The AC is a dynamic, evolving, web-based interactive game designed to generate a rich speech dataset, servin...

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