08 Tesi di dottorato (Doctoral Thesis)

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08.1 Tesi di dottorato (Doctoral Thesis) 3191

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OptoTrkB activation for in-vivo translation of optogenetic memory engram consolidation

The consolidation of memory engrams relies fundamentally on robust synaptic plasticity, specifically Late-phase Long-Term Potentiation (L-LTP), which is governed by the Brain-Derived Neurotrophic Factor (BDNF) and its high-affinity receptor, TrkB. While neuronal BDNF synthesis is critical, recent evidence suggests that astrocytes play an equally pivotal role in maintaining the pool of bioactive neurotrophins through a p75NTR-dependent recycling mechanism. This doctoral thesis investigates the...

Tracing the Dynamics of Value-Based Attention: from Generalization to Disengagement

In complex environments, the ability to selectively orient attention is crucial for adaptive behavior. A growing body of research has shown that stimuli previously associated with reward can capture attention even when they are no longer relevant or physically salient—a phenomenon known as Value-Modulated Attentional Capture (VMAC). While such value-driven biases are typically adaptive, facilitating the prioritization of motivationally relevant information, they may become maladaptive when th...

Development of tailored CRISPR tools for gene therapy applications: treatment of autosomal dominant retinitis pigmentosa

The CRISPR-Cas technology transformed the field of genome editing by allowing the easy and permanent modification of a target DNA sequence. Despite great improvements, the currently available gene editing toolbox still presents significant issues regarding specificity, deliverability and genomic target coverage. The aim of my thesis is to expand the number of available CRISPR enzymes by mining the human microbiome through Alia’s proprietary discovery platform. Novel nucleases with improved ch...

Delta-development of a critical space mechanism based on on-ground and in-flight testing experience

For centuries, our understanding of the cosmos has relied on observations of electromagnetic radiation - from radio waves to optical light. Yet, a revolutionary new mean has emerged: gravitational waves. These weak ripples in the fabric of spacetime offer a new way to listen to the cosmos. Unlike traditional astronomy, gravitational-wave unlocks the observation of some of the most energetic processes in the Universe. The first direct detection occurred in September 2015, when two ground-based...

Ricerche sull'epigramma romano da Catullo a Marziale

La presente tesi di dottorato discute lo sviluppo del genere epigrammatico tra la tarda repubblica e l’avvento dei Flavi, ovvero nell’arco cronologico che percorre dall’esperienza di Gaio Valerio Catullo a quella di Marco Valerio Marziale, i due principali rappresentanti del genere a Roma. Il lavoro è strutturato in cinque capitoli, raggruppati in due sezioni. La tesi è aperta da un’Introduzione che motiva la scelta del periodo preso in esame, inteso non solamente in funzione dei possibili mo...

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