08 Tesi di dottorato (Doctoral Thesis)

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08.1 Tesi di dottorato (Doctoral Thesis) 2747

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LA PALAFITTA DI LEDRO METODOLOGIE ED APPROCCI COMBINATI PER LA COMPRENSIONE DI UN SITO E DEL SUO TERRITORIO

Tre livelli di indagine, ad ingrandimenti diversi, sono in estrema sintesi l’immagine dell’opera presentata. Un primo livello pone il focus sulla palafitta di Ledro, sulla storia delle ricerche e sull’aggiornamento relativo allo studio dei materiali. Un secondo quadro di riflessione inserisce lo stesso sito all’interno della Valle di Ledro mostrando l’importanza della contestualizzazione di un ritrovamento nel territorio in cui esso è contenuto. L’ultimo livello di ingradimento raccoglie e co...

Symbolic Computation Methods for the Numerical Solution of Dynamic Systems Described by Differential-Algebraic Equations

In modern engineering, the accurate and efficient numerical simulation of dynamic systems is crucial, providing valuable insights across various fields such as automotive, aerospace, robotics, and electrical engineering. These simulations help to understand system behaviors, to optimize performance, and to guide design decisions. Nonetheless, systems described by Ordinary Differential Equations (ODEs) and Differential-Algebraic Equations (DAEs) are central to such simulations. While ODEs can ...

Translational defects in multiple tissues from the Smn2B/- mouse model of SMA.

Spinal muscular atrophy (SMA) is a devastating disorder caused by deletions and mutations in the survival of motor neuron (SMN1) gene and is marked by motor neuron loss and muscle weakness. While its genetic basis is clear, the underlying molecular mechanisms remain elusive. Decreased levels of the survival of motor neuron (SMN) protein, encoded by the SMN1 gene, are implicated in SMA pathology. Despite splicing has been under the spotlight as a major mechanism impaired in SMA, recent evidenc...

Towards Sustainable Braking: Effects of Alternative Ingredients on the Tribological Properties of Friction Materials

The most important safety device for commercial vehicles is the brake system. It has to satisfy multiple requirements such as braking performance, wear resistance and low noise production. In the last years, a further requirement has been gaining increasing attention: their particulate matter emission. Indeed, brake systems are one of the most relevant sources of non-exhaust traffic-related emission PM. These emissions have been shown to negatively affect both the environment and the human he...

Cancer microbiome characterization: tumor stage, location, genomic instability and patient outcome in CRC and melanoma

The microbiome's link to cancer is well-established, with evidence for its role in initiation, progression in colorectal cancer (CRC), and patient outcomes in melanoma. Additionally, microbiome modulation via fecal microbiota transplantation (FMT) is proposed to improve immunotherapy efficacy. In CRC, the microbiome presents a reproducible microbial signature, which is enriched in oral bacteria, such as Fusobacterium nucleatum and Gemella morbillorum. Despite extensive study of CRC characteri...

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