08 Tesi di dottorato (Doctoral Thesis)

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08.1 Tesi di dottorato (Doctoral Thesis) 2775

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Built Heritage Interface Models Multipurpose information access and data exchange

The research investigates models as interfaces to the built heritage, intended as representation forms and strategies for multipurpose information access and data exchange to enhance collaboration among practitioners and promote communication with stakeholders and generic audiences. After analyzing the research keywords through a theoretical framework, the study focuses on different methods and techniques for digital model development from data acquisition and processing, according to specifi...

Exploring the network’s world: From omics-driven machine learning workflow for drug target identification to quantification of signaling model diversity.

The drug discovery process is challenging, time-consuming, and costly, with drug target identification being an essential step in developing effective therapies. Drug repurposing offers a strategy for identifying new uses for existing drugs, aiming to simplify the process. Machine learning models and network analysis methods have demonstrated promise in both drug target identification and repurposing, providing powerful tools for analyzing complex biological data. This thesis will explore the...

READY-MADE MODEL. Digital tools for reality-based virtual landscapes

Over the past three decades, the digital and information revolution has reshaped design methodologies, offering dynamic and multi-level modelling approaches. Urban Digital Twins have emerged as a powerful tool for Smart Cities, facilitating scenario assessments and citizen engagement. However, rural and mountainous areas face challenges due to poor connectivity and digital infrastructure, hindering technological advancements in design processes. This doctoral thesis aims to develop sustainabl...

Understanding the metabolic mechanisms stimulated by plant-associated bacteria to enhance cold tolerance in tomato plants

Climate change is expected to increase the frequency of mild winters and warm springs, which can induce premature plant development. This premature development results in a high risk of exposure of young plant tissues to cold stress leading to severe reductions in plant growth and agricultural production. Plants are associated with complex bacterial communities that can activate acclimation processes and positively affect plant performance at low temperatures. Beneficial effects of plant colo...

Rise and Pitfalls of Synthetic Data for Abusive Language Detection

Synthetic data has been proposed as a method to potentially mitigate a number of issues with existing models and datasets for abusive language detection online, such as negative psychological impact on annotators, privacy issues, dataset obsolescence and representation bias. However, previous work on the topic has mostly focused on downstream task performance of models, without paying much attention to the evaluation of other aspects. In this thesis, we carry out a series of experiments and a...

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