The PIDDosome is a Caspase-2-activating platform assembling in response to centrosome amplification or genotoxic stress. We have recently shown that both stimuli depend on ANKRD26 (ankyrin repeat domain-containing protein 26)-mediated localization of PIDD1 (p53-inducible protein with death domain) at the centrosome, demonstrating how this organelle can directly influence cell fate.
The PIDDosome: centrosome guardian and backup on the DNA damage response / Burigotto, M.; Fava, L.. - In: MOLECULAR & CELLULAR ONCOLOGY. - ISSN 2372-3556. - ELETTRONICO. - 8:3(2021), p. 1893625. [10.1080/23723556.2021.1893625]
The PIDDosome: centrosome guardian and backup on the DNA damage response
Burigotto M.;Fava L.
2021-01-01
Abstract
The PIDDosome is a Caspase-2-activating platform assembling in response to centrosome amplification or genotoxic stress. We have recently shown that both stimuli depend on ANKRD26 (ankyrin repeat domain-containing protein 26)-mediated localization of PIDD1 (p53-inducible protein with death domain) at the centrosome, demonstrating how this organelle can directly influence cell fate.File in questo prodotto:
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