SCOPE: Milk powder is commonly consumed throughout the world. However, advanced glycation end products (AGEs) will form in milk powder during thermal processing and long-term storage. This study aimed to identify such compounds with potential as new urinary biomarkers of intake of heat-treated skimmed milk powder (HSMP). METHODS AND RESULTS: A parallel study is performed with different dosages of HSMP as well as hydrolyzed HSMP and untreated skimmed milk powder (SMP) in 36 rats. The 24-h urine samples on day 7 or 8 are collected and profiled by untargeted UPLC-Qtof-MS metabolomics. Statistical analysis revealed 25 metabolites differentiating SMP and HSMP; nineteen of these structures are proposed as lysine- and arginine-derived AGEs, and heterocyclic compounds. CONCLUSION: These metabolites may potentially serve as biomarkers of food intake pending further validation to assess intakes of heat-processed dairy foods and thus help to elucidate the effects of HSMP consumption or dietary AGEs on human health.

New Advanced Glycation End Products Observed in Rat Urine by Untargeted Metabolomics after Feeding with Heat-Treated Skimmed Milk Powder / Zhou, Xiaomin; Ulaszewska, Maria M; De Gobba, Cristian; Rinnan, Åsmund; Poulsen, Malene W; Chen, Jie; Mattivi, Fulvio; Hedegaard, Rikke Vingborg; Skibsted, Leif Horsfelt; Dragsted, Lars Ove. - In: MOLECULAR NUTRITION & FOOD RESEARCH. - ISSN 1613-4125. - 2021, 65:7(2021), pp. 2001049.1-2001049.9. [10.1002/mnfr.202001049]

New Advanced Glycation End Products Observed in Rat Urine by Untargeted Metabolomics after Feeding with Heat-Treated Skimmed Milk Powder

Mattivi, Fulvio;
2021-01-01

Abstract

SCOPE: Milk powder is commonly consumed throughout the world. However, advanced glycation end products (AGEs) will form in milk powder during thermal processing and long-term storage. This study aimed to identify such compounds with potential as new urinary biomarkers of intake of heat-treated skimmed milk powder (HSMP). METHODS AND RESULTS: A parallel study is performed with different dosages of HSMP as well as hydrolyzed HSMP and untreated skimmed milk powder (SMP) in 36 rats. The 24-h urine samples on day 7 or 8 are collected and profiled by untargeted UPLC-Qtof-MS metabolomics. Statistical analysis revealed 25 metabolites differentiating SMP and HSMP; nineteen of these structures are proposed as lysine- and arginine-derived AGEs, and heterocyclic compounds. CONCLUSION: These metabolites may potentially serve as biomarkers of food intake pending further validation to assess intakes of heat-processed dairy foods and thus help to elucidate the effects of HSMP consumption or dietary AGEs on human health.
2021
7
Zhou, Xiaomin; Ulaszewska, Maria M; De Gobba, Cristian; Rinnan, Åsmund; Poulsen, Malene W; Chen, Jie; Mattivi, Fulvio; Hedegaard, Rikke Vingborg; Skib...espandi
New Advanced Glycation End Products Observed in Rat Urine by Untargeted Metabolomics after Feeding with Heat-Treated Skimmed Milk Powder / Zhou, Xiaomin; Ulaszewska, Maria M; De Gobba, Cristian; Rinnan, Åsmund; Poulsen, Malene W; Chen, Jie; Mattivi, Fulvio; Hedegaard, Rikke Vingborg; Skibsted, Leif Horsfelt; Dragsted, Lars Ove. - In: MOLECULAR NUTRITION & FOOD RESEARCH. - ISSN 1613-4125. - 2021, 65:7(2021), pp. 2001049.1-2001049.9. [10.1002/mnfr.202001049]
File in questo prodotto:
File Dimensione Formato  
Zhou_et_al_Mol_Nutr_Food_Res_2021.pdf

Solo gestori archivio

Descrizione: articolo principale
Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 649.26 kB
Formato Adobe PDF
649.26 kB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/295195
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 4
social impact