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EnglishA bio-inspired multifunctionalized silk fibroin (BMS) was synthesized in order to mimic the interaction of nidogen with the type IV collagen and laminin of basement membranes. The designed BMS consists of a motif of laminin αchain-derived, called IK peptide, and type IV collagen covalently bound to the silk fibroin (SF) by using EDC/NHS coupling and a Cu-free click chemistry reaction, respectively. Silk fibroin was chosen as the main component of the BMS because it is versatile and biocompatible, induces an in vivo favorable bioresponse, and moreover can be functionalized with different methods. The chemical structure of BMS was analyzed by using X-ray photoelectron spectroscopy, attenuated total reflection-Fourier transform infrared, cross-polarization magic angle spinning nuclear magnetic resonance techniques, and colorimetric assay. The SF and BMS solutions were cross-linked by sonication to form hydrogels or casted to make films in order to evaluate and compare the early adhesion and viability of MRC5 cells. BMS hydrogels were also characterized by rheological and thermal analyses.
A bio-inspired multifunctionalized silk fibroin / Santi, S.; Mancini, I.; Dirè, S.; Callone, E.; Speranza, G.; Pugno, N.; Migliaresi, C.; Motta, A.. - In: ACS BIOMATERIALS SCIENCE & ENGINEERING. - ISSN 2373-9878. - 7:2(2021), pp. 507-516. [10.1021/acsbiomaterials.0c01567]
| Titolo: | A bio-inspired multifunctionalized silk fibroin | |
| Autori: | Santi, S.; Mancini, I.; Dirè, S.; Callone, E.; Speranza, G.; Pugno, N.; Migliaresi, C.; Motta, A. | |
| Autori Unitn: | ||
| Titolo del periodico: | ACS BIOMATERIALS SCIENCE & ENGINEERING | |
| Anno di pubblicazione: | 2021 | |
| Numero e parte del fascicolo: | 2 | |
| Codice identificativo Scopus: | 2-s2.0-85100232929 | |
| Codice identificativo Pubmed: | 33476122 | |
| Codice identificativo WOS: | WOS:000618655200013 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1021/acsbiomaterials.0c01567 | |
| Handle: | http://hdl.handle.net/11572/293887 | |
| Citazione: | A bio-inspired multifunctionalized silk fibroin / Santi, S.; Mancini, I.; Dirè, S.; Callone, E.; Speranza, G.; Pugno, N.; Migliaresi, C.; Motta, A.. - In: ACS BIOMATERIALS SCIENCE & ENGINEERING. - ISSN 2373-9878. - 7:2(2021), pp. 507-516. [10.1021/acsbiomaterials.0c01567] | |
| Appare nelle tipologie: | 03.1 Articolo su rivista (Journal article) |
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