The effective reproduction ratio r(t) parameter of an epidemic, defined as the average number of secondary infected cases per infectious case in a population in the current state, including both susceptible and non-susceptible hosts, controls the transition between a sub-critical threshold regime (r(t) < 1) and a supercritical threshold regime r(t) > 1). While in sub-critical regimes, an index infected case will cause an outbreak that will die out sooner or later, with large fluctuations observed when approaching the epidemic threshold, the supercritical regimes leads to an exponential growths of infection. The super- or sub-critical regime of an outbreak is often not distinguished when close to the epidemic threshold, but its behaviour is of major importance to understand the course of an epidemic and public health management of disease control. In a sub-critical parameter regime undetected infection, here called “imported case” or import, i.e. a susceptible individual becoming infected from outside the study area e.g., can either spark recurrent isolated outbreaks or keep the ongoing levels of infection, but cannot cause an exponential growths of infection. However, when the community transmission becomes super-critical, any index case or few “imported cases” will lead the epidemic to an exponential growths of infections, hence being distinguished from the sub-critical dynamics by a critical epidemic threshold in which large fluctuations occur in stochastic versions of the considered processes. As a continuation of the COVID-19 Basque Modeling Task Force (BMTF), we now investigate the role of critical fluctuations and import in basic Susceptible-Infected-Susceptible (SIS) and Susceptible-Infected-Recovered (SIR) epidemiological models on disease spreading dynamics. Without loss of generality, these simple models can be treated analytically and, when considering the mean field approximation of more complex underlying stochastic and eventually spatially extended or generalized network processes, results can be applied to more complex models used to describe the COVID-19 epidemics. In this paper, we explore possible features of the course of an epidemic, showing that the sub-critical regime can explain the dynamic behaviour of COVID-19 spreading in the Basque Country, with this theory supported by real data

The interplay between subcritical fluctuations and import: understanding COVID-19 epidemiology dynamics / Stollenwerk, Nico; Van-Dierdonck, Joseba Bidaurrazaga; Mar, Javier; Arrizabalaga, Irati Eguiguren; Cusimano, Nicole; Knopoff, Damián; Anam, Vizda; Aguiar, Maíra. - ELETTRONICO. - 2021:(2021), pp. 1-34. [10.1101/2020.12.25.20248840]

The interplay between subcritical fluctuations and import: understanding COVID-19 epidemiology dynamics

Aguiar, Maíra
2021

Abstract

The effective reproduction ratio r(t) parameter of an epidemic, defined as the average number of secondary infected cases per infectious case in a population in the current state, including both susceptible and non-susceptible hosts, controls the transition between a sub-critical threshold regime (r(t) < 1) and a supercritical threshold regime r(t) > 1). While in sub-critical regimes, an index infected case will cause an outbreak that will die out sooner or later, with large fluctuations observed when approaching the epidemic threshold, the supercritical regimes leads to an exponential growths of infection. The super- or sub-critical regime of an outbreak is often not distinguished when close to the epidemic threshold, but its behaviour is of major importance to understand the course of an epidemic and public health management of disease control. In a sub-critical parameter regime undetected infection, here called “imported case” or import, i.e. a susceptible individual becoming infected from outside the study area e.g., can either spark recurrent isolated outbreaks or keep the ongoing levels of infection, but cannot cause an exponential growths of infection. However, when the community transmission becomes super-critical, any index case or few “imported cases” will lead the epidemic to an exponential growths of infections, hence being distinguished from the sub-critical dynamics by a critical epidemic threshold in which large fluctuations occur in stochastic versions of the considered processes. As a continuation of the COVID-19 Basque Modeling Task Force (BMTF), we now investigate the role of critical fluctuations and import in basic Susceptible-Infected-Susceptible (SIS) and Susceptible-Infected-Recovered (SIR) epidemiological models on disease spreading dynamics. Without loss of generality, these simple models can be treated analytically and, when considering the mean field approximation of more complex underlying stochastic and eventually spatially extended or generalized network processes, results can be applied to more complex models used to describe the COVID-19 epidemics. In this paper, we explore possible features of the course of an epidemic, showing that the sub-critical regime can explain the dynamic behaviour of COVID-19 spreading in the Basque Country, with this theory supported by real data
Stollenwerk, Nico; Van-Dierdonck, Joseba Bidaurrazaga; Mar, Javier; Arrizabalaga, Irati Eguiguren; Cusimano, Nicole; Knopoff, Damián; Anam, Vizda; Aguiar, Maíra
The interplay between subcritical fluctuations and import: understanding COVID-19 epidemiology dynamics / Stollenwerk, Nico; Van-Dierdonck, Joseba Bidaurrazaga; Mar, Javier; Arrizabalaga, Irati Eguiguren; Cusimano, Nicole; Knopoff, Damián; Anam, Vizda; Aguiar, Maíra. - ELETTRONICO. - 2021:(2021), pp. 1-34. [10.1101/2020.12.25.20248840]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11572/292081
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