OBJECTIVE: Clinical data suggest early involvement of the corticospinal tract (CST) in spinocerebellar ataxia type 2 (SCA2). Here we tested if early CST degeneration can be detected in prodromal SCA2 mutation carriers by electrophysiological markers of CST integrity. METHODS: CST integrity was tested in 15 prodromal SCA2 mutation carriers, 19 SCA2 patients and 25 age-matched healthy controls, using corticomuscular (EEG-EMG) and intermuscular (EMG-EMG) coherence measures in upper and lower limb muscles. RESULTS: Significant reductions of EEG-EMG and EMG-EMG coherences were observed in the SCA2 patients, and to a similar extent in the prodromal SCA2 mutation carriers. In prodromal SCA2, EEG-EMG and EMG-EMG coherences correlated with the predicted time to ataxia onset. CONCLUSIONS: Findings indicate early CST neurodegeneration in SCA2. EEG-EMG and EMG-EMG coherence may serve as biomarkers of early CST neurodegeneration in prodromal SCA2 mutation carriers. SIGNIFICANCE: Findings are important for developing preclinical disease markers in the context of currently emerging disease-modifying therapies of neurodegenerative disorders. © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Early corticospinal tract damage in prodromal SCA2 revealed by EEG-EMG and EMG-EMG coherence / Luis, Velázquez-Pérez; Johannes, Tünnerhoff; Roberto, Rodríguez-Labrada; Reidenis, Torres-Vega; Yusely, Ruiz-Gonzalez; Belardinelli, P; Jacqueline, Medrano-Montero; Nalia, Canales-Ochoa; Yanetza, González-Zaldivar; Yaimeé, Vazquez-Mojena; Georg, Auburger; Ulf, Ziemann. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 2017, 128:12(2017), pp. 2493-2502. [https:// doi.org/10.1016/j.clinph.2017.10.009]

Early corticospinal tract damage in prodromal SCA2 revealed by EEG-EMG and EMG-EMG coherence

Belardinelli P;
2017-01-01

Abstract

OBJECTIVE: Clinical data suggest early involvement of the corticospinal tract (CST) in spinocerebellar ataxia type 2 (SCA2). Here we tested if early CST degeneration can be detected in prodromal SCA2 mutation carriers by electrophysiological markers of CST integrity. METHODS: CST integrity was tested in 15 prodromal SCA2 mutation carriers, 19 SCA2 patients and 25 age-matched healthy controls, using corticomuscular (EEG-EMG) and intermuscular (EMG-EMG) coherence measures in upper and lower limb muscles. RESULTS: Significant reductions of EEG-EMG and EMG-EMG coherences were observed in the SCA2 patients, and to a similar extent in the prodromal SCA2 mutation carriers. In prodromal SCA2, EEG-EMG and EMG-EMG coherences correlated with the predicted time to ataxia onset. CONCLUSIONS: Findings indicate early CST neurodegeneration in SCA2. EEG-EMG and EMG-EMG coherence may serve as biomarkers of early CST neurodegeneration in prodromal SCA2 mutation carriers. SIGNIFICANCE: Findings are important for developing preclinical disease markers in the context of currently emerging disease-modifying therapies of neurodegenerative disorders. © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
2017
12
Luis, Velázquez-Pérez; Johannes, Tünnerhoff; Roberto, Rodríguez-Labrada; Reidenis, Torres-Vega; Yusely, Ruiz-Gonzalez; Belardinelli, P; Jacqueline, Me...espandi
Early corticospinal tract damage in prodromal SCA2 revealed by EEG-EMG and EMG-EMG coherence / Luis, Velázquez-Pérez; Johannes, Tünnerhoff; Roberto, Rodríguez-Labrada; Reidenis, Torres-Vega; Yusely, Ruiz-Gonzalez; Belardinelli, P; Jacqueline, Medrano-Montero; Nalia, Canales-Ochoa; Yanetza, González-Zaldivar; Yaimeé, Vazquez-Mojena; Georg, Auburger; Ulf, Ziemann. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 2017, 128:12(2017), pp. 2493-2502. [https:// doi.org/10.1016/j.clinph.2017.10.009]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/290406
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