BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique with potential for cost-effective therapeutic neuromodulation. Although positive therapeutic effects were found by stimulating the dorsolateral prefrontal cortex (DLPFC), few studies have investigated physiological effects of DLPFC-tDCS. OBJECTIVES: To investigate effects of tDCS with different parameter settings applied to the left DLPFC on cortical responses, measured by resting-state electroencephalography (rs-EEG) and transcranial magnetic stimulation (TMS)-evoked/induced EEG responses. METHODS: 22 healthy subjects underwent 5 tDCS sessions with different tDCS parameter settings in a double-blinded randomized crossover design (1: 1.5 mA, anode left-DLPFC, cathode right-DLPFC; 2: 1.5 mA, cathode left-DLPFC, anode right-DLPFC; 3: 0.5 mA, anode left-DLPFC, cathode right-DLPFC; 4: 1.5 mA, anode left-DLPFC, cathode left deltoid muscle; 5: sham stimulation). Rs-EEG and TMS-EEG were recorded before and after tDCS. RESULTS: Rs-EEG power spectrum analysis showed no difference comparing baseline with post stimulation in any of the tDCS conditions. TMS-EEG evoked potential amplitude decreased in parietal cortex after 1.5 mA left-DLPFC anodal tDCS, and TMS-induced gamma and theta oscillations decreased after all conditions using left-DLPFC anodal tDCS. Left-DLPFC cathodal tDCS did not lead to significant change. None of the post-intervention changes was different when comparing the effects across conditions, including sham. CONCLUSIONS: Our study does not provide evidence that a single tDCS session results in significant changes in rs-EEG, using the current stimulation parameters. Significant changes in EEG responses to TMS pulses were observed following the anodal 1.5 mA tDCS interventions, although these changes were not statistically significant in a group comparison.

Modulation of cortical responses by transcranial direct current stimulation of dorsolateral prefrontal cortex: a resting-state EEG and TMS-EEG study / Caldana Gordona, Pedro; Zrennera, Christoph; Desideria, Debora; Belardinelli, Paolo; Zrennera, Brigitte; Russowsky Brunoni, André; Ziemann, Ulf. - In: BRAIN STIMULATION. - ISSN 1935-861X. - 2018, 11:5(2018), pp. 1024-1032. [10.1016/j.brs.2018.06.004]

Modulation of cortical responses by transcranial direct current stimulation of dorsolateral prefrontal cortex: a resting-state EEG and TMS-EEG study

Belardinelli, Paolo;
2018-01-01

Abstract

BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique with potential for cost-effective therapeutic neuromodulation. Although positive therapeutic effects were found by stimulating the dorsolateral prefrontal cortex (DLPFC), few studies have investigated physiological effects of DLPFC-tDCS. OBJECTIVES: To investigate effects of tDCS with different parameter settings applied to the left DLPFC on cortical responses, measured by resting-state electroencephalography (rs-EEG) and transcranial magnetic stimulation (TMS)-evoked/induced EEG responses. METHODS: 22 healthy subjects underwent 5 tDCS sessions with different tDCS parameter settings in a double-blinded randomized crossover design (1: 1.5 mA, anode left-DLPFC, cathode right-DLPFC; 2: 1.5 mA, cathode left-DLPFC, anode right-DLPFC; 3: 0.5 mA, anode left-DLPFC, cathode right-DLPFC; 4: 1.5 mA, anode left-DLPFC, cathode left deltoid muscle; 5: sham stimulation). Rs-EEG and TMS-EEG were recorded before and after tDCS. RESULTS: Rs-EEG power spectrum analysis showed no difference comparing baseline with post stimulation in any of the tDCS conditions. TMS-EEG evoked potential amplitude decreased in parietal cortex after 1.5 mA left-DLPFC anodal tDCS, and TMS-induced gamma and theta oscillations decreased after all conditions using left-DLPFC anodal tDCS. Left-DLPFC cathodal tDCS did not lead to significant change. None of the post-intervention changes was different when comparing the effects across conditions, including sham. CONCLUSIONS: Our study does not provide evidence that a single tDCS session results in significant changes in rs-EEG, using the current stimulation parameters. Significant changes in EEG responses to TMS pulses were observed following the anodal 1.5 mA tDCS interventions, although these changes were not statistically significant in a group comparison.
2018
5
Caldana Gordona, Pedro; Zrennera, Christoph; Desideria, Debora; Belardinelli, Paolo; Zrennera, Brigitte; Russowsky Brunoni, André; Ziemann, Ulf...espandi
Modulation of cortical responses by transcranial direct current stimulation of dorsolateral prefrontal cortex: a resting-state EEG and TMS-EEG study / Caldana Gordona, Pedro; Zrennera, Christoph; Desideria, Debora; Belardinelli, Paolo; Zrennera, Brigitte; Russowsky Brunoni, André; Ziemann, Ulf. - In: BRAIN STIMULATION. - ISSN 1935-861X. - 2018, 11:5(2018), pp. 1024-1032. [10.1016/j.brs.2018.06.004]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/290398
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