Atrial fibrillation (AF) is a multifactorial disease, which often occurs in the presence of underlying cardiac abnormalities and is supported by electrophysiological and structural alterations, generally referred to as atrial remodeling. Abnormal substrates are commonly encountered in various conditions that predispose to AF, such as hypertension, heart failure, obesity, and sleep apnea, in which atrial stretch plays a key mechanistic role. Emerging evidence suggests a role for microRNAs (small non-coding RNAs) in the pathogenesis of AF, where they can act as post-transcriptional regulators of the genes involved in atrial remodeling. This review summarizes the experimental and clinical evidence that supports the role of microRNAs in the modulation of atrial electrical and structural remodeling with a focus on overload-induced atrial alterations, and discusses the potential contribution of microRNAs to mechano-electrical coupling and AF.

MicroRNAs: New contributors to mechano-electric coupling and atrial fibrillation / Ravelli, F.; Masè, M.. - In: PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY. - ISSN 0079-6107. - 159:(2021), pp. 146-156. [10.1016/j.pbiomolbio.2020.09.007]

MicroRNAs: New contributors to mechano-electric coupling and atrial fibrillation

Ravelli, F.;Masè, M.
2021-01-01

Abstract

Atrial fibrillation (AF) is a multifactorial disease, which often occurs in the presence of underlying cardiac abnormalities and is supported by electrophysiological and structural alterations, generally referred to as atrial remodeling. Abnormal substrates are commonly encountered in various conditions that predispose to AF, such as hypertension, heart failure, obesity, and sleep apnea, in which atrial stretch plays a key mechanistic role. Emerging evidence suggests a role for microRNAs (small non-coding RNAs) in the pathogenesis of AF, where they can act as post-transcriptional regulators of the genes involved in atrial remodeling. This review summarizes the experimental and clinical evidence that supports the role of microRNAs in the modulation of atrial electrical and structural remodeling with a focus on overload-induced atrial alterations, and discusses the potential contribution of microRNAs to mechano-electrical coupling and AF.
2021
Ravelli, F.; Masè, M.
MicroRNAs: New contributors to mechano-electric coupling and atrial fibrillation / Ravelli, F.; Masè, M.. - In: PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY. - ISSN 0079-6107. - 159:(2021), pp. 146-156. [10.1016/j.pbiomolbio.2020.09.007]
File in questo prodotto:
File Dimensione Formato  
Progress in Biophysics and Molecular Biology 2021.pdf

Solo gestori archivio

Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 823.65 kB
Formato Adobe PDF
823.65 kB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/289748
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 6
social impact