The market of olive-based dietary supplements (OBDS) is composed of a broad range of natural extracts claiming different health effects and often sold without a clear statement on their chemical composition. The aim of this survey was to characterize the chemical profiles of 14 commercially available OBDS. As many as 378 compounds were tentatively annotated in the analyzed samples. Although for most of metabolites the annotation at level I was prevented due to the lack of the analytical standard, the spectra obtained from high-resolution tandem mass spectrometry (MS/MS) measurements were very informative, allowing annotation of dozens of metabolites at level II or III. A targeted method allowed the quantification of 26 selected compounds. A large qualitative and quantitative variability was observed. The products obtained from buds by glyceric maceration were those with the lowest concentrations of all the quantified elements. The dose of 5 mg of hydroxytyrosol, corresponding to the European Food Safety Authority (EFSA) health claim, was only reached by four products, all of them originating from the olive fruit or the leaves. If we also take into consideration oleuropein, two additional products provide this daily amount. This work demonstrates the high complexity and diversity in the composition of OBDS.

Exploratory Analysis of Commercial Olive-Based Dietary Supplements Using Untargeted and Targeted Metabolomics / Garcia-Aloy, Mar; Groff, Nelli; Masuero, Domenico; Nisi, Mauro; Franco, Antonio; Battelini, Furio; Vrhovsek, Urska; Mattivi, Fulvio. - In: METABOLITES. - ISSN 2218-1989. - 10:12(2020), pp. 51601-51626. [10.3390/metabo10120516]

Exploratory Analysis of Commercial Olive-Based Dietary Supplements Using Untargeted and Targeted Metabolomics

Masuero, Domenico;Vrhovsek, Urska;Mattivi, Fulvio
2020

Abstract

The market of olive-based dietary supplements (OBDS) is composed of a broad range of natural extracts claiming different health effects and often sold without a clear statement on their chemical composition. The aim of this survey was to characterize the chemical profiles of 14 commercially available OBDS. As many as 378 compounds were tentatively annotated in the analyzed samples. Although for most of metabolites the annotation at level I was prevented due to the lack of the analytical standard, the spectra obtained from high-resolution tandem mass spectrometry (MS/MS) measurements were very informative, allowing annotation of dozens of metabolites at level II or III. A targeted method allowed the quantification of 26 selected compounds. A large qualitative and quantitative variability was observed. The products obtained from buds by glyceric maceration were those with the lowest concentrations of all the quantified elements. The dose of 5 mg of hydroxytyrosol, corresponding to the European Food Safety Authority (EFSA) health claim, was only reached by four products, all of them originating from the olive fruit or the leaves. If we also take into consideration oleuropein, two additional products provide this daily amount. This work demonstrates the high complexity and diversity in the composition of OBDS.
12
Garcia-Aloy, Mar; Groff, Nelli; Masuero, Domenico; Nisi, Mauro; Franco, Antonio; Battelini, Furio; Vrhovsek, Urska; Mattivi, Fulvio
Exploratory Analysis of Commercial Olive-Based Dietary Supplements Using Untargeted and Targeted Metabolomics / Garcia-Aloy, Mar; Groff, Nelli; Masuero, Domenico; Nisi, Mauro; Franco, Antonio; Battelini, Furio; Vrhovsek, Urska; Mattivi, Fulvio. - In: METABOLITES. - ISSN 2218-1989. - 10:12(2020), pp. 51601-51626. [10.3390/metabo10120516]
File in questo prodotto:
File Dimensione Formato  
Garcia-Aloy_et_al_Metabolites_2020.pdf

accesso aperto

Descrizione: articolo principale
Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Creative commons
Dimensione 1.26 MB
Formato Adobe PDF
1.26 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11572/284834
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact