Cyclin Dependent Kinases (CDKs) regulate the cell division cycle, apoptosis, transcription and differentiation in addition to functions in the nervous system. They are regulated by their cyclin partners and by a variety of additional protein effectors (inhibitors, kinases, phosphatases). Each CDK serves its function by means of specific protein recognition properties. These are also responsible for the differential regulation of CDKs/Cyclin couples involved in processes as different as cell cycle and transcription. The structural features determining general and specific properties for CDKs/Cyclin complexes are analyzed. They reside in an overall conserved architecture with divergent spots used by the complexes to present themselves to specific substrates or other protein effectors.

Structural dissection of cyclin dependent kinases regulation and protein recognition properties / Lolli, Graziano. - In: CELL CYCLE. - ISSN 1538-4101. - STAMPA. - 9:(2010), pp. 1551-1561. [10.4161/cc.9.8.11195]

Structural dissection of cyclin dependent kinases regulation and protein recognition properties

LOLLI, GRAZIANO
2010-01-01

Abstract

Cyclin Dependent Kinases (CDKs) regulate the cell division cycle, apoptosis, transcription and differentiation in addition to functions in the nervous system. They are regulated by their cyclin partners and by a variety of additional protein effectors (inhibitors, kinases, phosphatases). Each CDK serves its function by means of specific protein recognition properties. These are also responsible for the differential regulation of CDKs/Cyclin couples involved in processes as different as cell cycle and transcription. The structural features determining general and specific properties for CDKs/Cyclin complexes are analyzed. They reside in an overall conserved architecture with divergent spots used by the complexes to present themselves to specific substrates or other protein effectors.
2010
Lolli, Graziano
Structural dissection of cyclin dependent kinases regulation and protein recognition properties / Lolli, Graziano. - In: CELL CYCLE. - ISSN 1538-4101. - STAMPA. - 9:(2010), pp. 1551-1561. [10.4161/cc.9.8.11195]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/284420
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