The lateral prefrontal cortex of primates (lPFC) plays a central role in complex cognitive behavior, in decision-making as well as in guiding top-down attention. However, how and where in lPFC such behaviorally relevant signals are computed is poorly understood. We analyzed neural recordings from chronic microelectrode arrays implanted in lPFC region 8Av/45 of two rhesus macaques. The animals performed a feature match-to-sample task requiring them to match both motion and color information in a test stimulus. This task allowed to separate the encoding of stimulus motion and color from their current behavioral relevance on a trial-by-trial basis. We found that upcoming motor behavior can be robustly predicted from lPFC activity. In addition, we show that 8Av/45 encodes the color of a visual stimulus, regardless of its behavioral relevance. Most notably, whether a color matches the searched-for color can be decoded independent of a trial’s motor outcome and while subjects detect unique feature conjunctions of color and motion. Thus, macaque area 8Av/45 computes, among other task-relevant information, the behavioral relevance of visual color features. Such a signal is most critical for both the selection of responses as well as the deployment of top-down modulatory signals, like feature-based attention.
The lateral prefrontal cortex of primates encodes stimulus colors and their behavioral relevance during a match-to-sample task / Schwedhelm, P.; Baldauf, D.; Treue, S.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 10:1(2020), p. 4216. [10.1038/s41598-020-61171-3]
Titolo: | The lateral prefrontal cortex of primates encodes stimulus colors and their behavioral relevance during a match-to-sample task | |
Autori: | Schwedhelm, P.; Baldauf, D.; Treue, S. | |
Autori Unitn: | ||
Titolo del periodico: | SCIENTIFIC REPORTS | |
Anno di pubblicazione: | 2020 | |
Numero e parte del fascicolo: | 1 | |
Codice identificativo Scopus: | 2-s2.0-85081531786 | |
Codice identificativo Pubmed: | 32144331 | |
Codice identificativo WOS: | MEDLINE:32144331 | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/s41598-020-61171-3 | |
Handle: | http://hdl.handle.net/11572/282150 | |
Citazione: | The lateral prefrontal cortex of primates encodes stimulus colors and their behavioral relevance during a match-to-sample task / Schwedhelm, P.; Baldauf, D.; Treue, S.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 10:1(2020), p. 4216. [10.1038/s41598-020-61171-3] | |
Appare nelle tipologie: | 03.1 Articolo su rivista (Journal article) |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
---|---|---|---|---|
Schwedhelm_PFC_SciRep2020.pdf | Versione editoriale (Publisher’s layout) | Tutti i diritti riservati (All rights reserved) | Open Access Visualizza/Apri |