The search for mechanisms underlying different cellular responses to the treatment with Nutlin-3, an MDM2 inhibitor that unleashes p53, revealed a translational control mechanism involving the RNA binding proteins PCBP2 and, particularly, DHX30. Sifting through a multi-functional p53-dependent transcriptional output, this translational control can modulate the activation of cell death pathways.

Translation control can shape TP53-dependent cell fate / Rizzotto, Dario; Zaccara, Sara; Rossi, Annalisa; Dassi, Erik; Inga, Alberto. - In: MOLECULAR & CELLULAR ONCOLOGY. - ISSN 2372-3556. - 2020, 7:5(2020), pp. 1767483.1-1767483.2. [10.1080/23723556.2020.1767483]

Translation control can shape TP53-dependent cell fate

Rizzotto, Dario;Zaccara, Sara;Rossi, Annalisa;Dassi, Erik;Inga, Alberto
2020

Abstract

The search for mechanisms underlying different cellular responses to the treatment with Nutlin-3, an MDM2 inhibitor that unleashes p53, revealed a translational control mechanism involving the RNA binding proteins PCBP2 and, particularly, DHX30. Sifting through a multi-functional p53-dependent transcriptional output, this translational control can modulate the activation of cell death pathways.
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Rizzotto, Dario; Zaccara, Sara; Rossi, Annalisa; Dassi, Erik; Inga, Alberto
Translation control can shape TP53-dependent cell fate / Rizzotto, Dario; Zaccara, Sara; Rossi, Annalisa; Dassi, Erik; Inga, Alberto. - In: MOLECULAR & CELLULAR ONCOLOGY. - ISSN 2372-3556. - 2020, 7:5(2020), pp. 1767483.1-1767483.2. [10.1080/23723556.2020.1767483]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11572/280369
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