The search for mechanisms underlying different cellular responses to the treatment with Nutlin-3, an MDM2 inhibitor that unleashes p53, revealed a translational control mechanism involving the RNA binding proteins PCBP2 and, particularly, DHX30. Sifting through a multi-functional p53-dependent transcriptional output, this translational control can modulate the activation of cell death pathways.
Translation control can shape TP53-dependent cell fate / Rizzotto, Dario; Zaccara, Sara; Rossi, Annalisa; Dassi, Erik; Inga, Alberto. - In: MOLECULAR & CELLULAR ONCOLOGY. - ISSN 2372-3556. - 2020, 7:5(2020), pp. 1767483.1-1767483.2. [10.1080/23723556.2020.1767483]
Translation control can shape TP53-dependent cell fate
Rizzotto, Dario;Zaccara, Sara;Rossi, Annalisa;Dassi, Erik;Inga, Alberto
2020
Abstract
The search for mechanisms underlying different cellular responses to the treatment with Nutlin-3, an MDM2 inhibitor that unleashes p53, revealed a translational control mechanism involving the RNA binding proteins PCBP2 and, particularly, DHX30. Sifting through a multi-functional p53-dependent transcriptional output, this translational control can modulate the activation of cell death pathways.| File | Dimensione | Formato | |
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Translation control can shape TP53 dependent cell fate.pdf
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