Clinical trials and case reports of cancer therapies combining radiation therapy with immunotherapy have at times demonstrated total reduction or elimination of metastatic disease. While virtually all trials focus on the use of immunotherapy combined with conventional photon irradiation, the dose-distributive benefits of particles, in particular the distinct biological effects of heavy ions, have unknown potential vis-a-vis systemic disease response. Here, we review recent developments and evidence with a focus on the potential for heavy-ion combination therapy.

Combining heavy-ion therapy with immunotherapy: An update on recent developments / Helm, A.; Ebner, D. K.; Tinganelli, W.; Simoniello, P.; Bisio, A.; Marchesano, V.; Durante, M.; Yamada, S.; Shimokawa, T.. - In: INTERNATIONAL JOURNAL OF PARTICLE THERAPY. - ISSN 2331-5180. - 5:1(2018), pp. 84-93. [10.14338/IJPT-18-00024.1]

Combining heavy-ion therapy with immunotherapy: An update on recent developments

Bisio A.;
2018

Abstract

Clinical trials and case reports of cancer therapies combining radiation therapy with immunotherapy have at times demonstrated total reduction or elimination of metastatic disease. While virtually all trials focus on the use of immunotherapy combined with conventional photon irradiation, the dose-distributive benefits of particles, in particular the distinct biological effects of heavy ions, have unknown potential vis-a-vis systemic disease response. Here, we review recent developments and evidence with a focus on the potential for heavy-ion combination therapy.
1
Helm, A.; Ebner, D. K.; Tinganelli, W.; Simoniello, P.; Bisio, A.; Marchesano, V.; Durante, M.; Yamada, S.; Shimokawa, T.
Combining heavy-ion therapy with immunotherapy: An update on recent developments / Helm, A.; Ebner, D. K.; Tinganelli, W.; Simoniello, P.; Bisio, A.; Marchesano, V.; Durante, M.; Yamada, S.; Shimokawa, T.. - In: INTERNATIONAL JOURNAL OF PARTICLE THERAPY. - ISSN 2331-5180. - 5:1(2018), pp. 84-93. [10.14338/IJPT-18-00024.1]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11572/270746
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