Coordinated reach-to-grasp movements are often accompanied by rapid eye movements (saccades) that displace the desired object image relative to the retina. Parietal cortex compensates for this by updating reach goals relative to current gaze direction, but its role in the integration of oculomotor and visual orientation signals for updating grasp plans is unknown. Based on a recent perceptual experiment, we hypothesized that inferior parietal cortex (specifically supramarginal gyrus; SMG) integrates saccade and visual signals to update grasp plans in additional intraparietal / superior parietal regions. To test this hypothesis in humans (7 females, 6 males), we employed a functional magnetic resonance adaptation paradigm, where saccades sometimes interrupted grasp preparation toward a briefly presented object that later reappeared (with the same/different orientation) just before movement. Right SMG and several parietal grasp regions, namely left anterior intraparietal sulcus (aIPS) and bilateral superior parietal lobule (SPL), met our criteria for transsaccadic orientation integration: they showed task-dependent saccade modulations and, during grasp execution, they were specifically sensitive to changes in object orientation that followed saccades. Finally, SMG showed enhanced functional connectivity with both prefrontal saccade regions (consistent with oculomotor input) and aIPS / SPL (consistent with sensorimotor output). These results support the general role of parietal cortex for the integration of visuospatial perturbations, and provide specific cortical modules for the integration of oculomotor and visual signals for grasp updating.

Parietal cortex integrates saccade and object orientation signals to update grasp plans / Baltaretu, B. R.; Monaco, S.; Velji-Ibrahim, J.; Luabeya, G. N.; Douglas Crawford, J.. - In: THE JOURNAL OF NEUROSCIENCE. - ISSN 0270-6474. - ELETTRONICO. - 40:23(2020), pp. 4525-4535. [10.1523/JNEUROSCI.0300-20.2020]

Parietal cortex integrates saccade and object orientation signals to update grasp plans

Monaco S.;
2020-01-01

Abstract

Coordinated reach-to-grasp movements are often accompanied by rapid eye movements (saccades) that displace the desired object image relative to the retina. Parietal cortex compensates for this by updating reach goals relative to current gaze direction, but its role in the integration of oculomotor and visual orientation signals for updating grasp plans is unknown. Based on a recent perceptual experiment, we hypothesized that inferior parietal cortex (specifically supramarginal gyrus; SMG) integrates saccade and visual signals to update grasp plans in additional intraparietal / superior parietal regions. To test this hypothesis in humans (7 females, 6 males), we employed a functional magnetic resonance adaptation paradigm, where saccades sometimes interrupted grasp preparation toward a briefly presented object that later reappeared (with the same/different orientation) just before movement. Right SMG and several parietal grasp regions, namely left anterior intraparietal sulcus (aIPS) and bilateral superior parietal lobule (SPL), met our criteria for transsaccadic orientation integration: they showed task-dependent saccade modulations and, during grasp execution, they were specifically sensitive to changes in object orientation that followed saccades. Finally, SMG showed enhanced functional connectivity with both prefrontal saccade regions (consistent with oculomotor input) and aIPS / SPL (consistent with sensorimotor output). These results support the general role of parietal cortex for the integration of visuospatial perturbations, and provide specific cortical modules for the integration of oculomotor and visual signals for grasp updating.
2020
23
Baltaretu, B. R.; Monaco, S.; Velji-Ibrahim, J.; Luabeya, G. N.; Douglas Crawford, J.
Parietal cortex integrates saccade and object orientation signals to update grasp plans / Baltaretu, B. R.; Monaco, S.; Velji-Ibrahim, J.; Luabeya, G. N.; Douglas Crawford, J.. - In: THE JOURNAL OF NEUROSCIENCE. - ISSN 0270-6474. - ELETTRONICO. - 40:23(2020), pp. 4525-4535. [10.1523/JNEUROSCI.0300-20.2020]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/270275
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