Abundant evidence points to a crucial physiological role for cellular senescence in combating tumorigenesis. Thus, the engagement of senescence may represent a key component for therapeutic intervention in the eradication of cancer. In this Opinion article, we focus on concepts that are relevant to a pro-senescence approach to therapy and we propose potential therapeutic strategies that aim to enhance the pro-senescence response in tumours. © 2011 Macmillan Publishers Limited. All rights reserved.
Pro-senescence therapy for cancer treatment / Nardella, C.; Clohessy, J. G.; Alimonti, A.; Pandolfi, P. P.. - In: NATURE REVIEWS CANCER. - ISSN 1474-175X. - 11:7(2011), pp. 503-511. [10.1038/nrc3057]
Pro-senescence therapy for cancer treatment
Nardella C.;
2011-01-01
Abstract
Abundant evidence points to a crucial physiological role for cellular senescence in combating tumorigenesis. Thus, the engagement of senescence may represent a key component for therapeutic intervention in the eradication of cancer. In this Opinion article, we focus on concepts that are relevant to a pro-senescence approach to therapy and we propose potential therapeutic strategies that aim to enhance the pro-senescence response in tumours. © 2011 Macmillan Publishers Limited. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione
