The present work describes a novel nanocrystalline, multidoped hydroxyapatite featuring excellent eukaryotic versus prokaryotic cell selectivity, attested by excellent osteoinductive character and evaluated with human stem cells, and anti-infective ability, tested against different pathogens. Physicochemical analysis and transmission electron microscopy (TEM)/scanning STEM observations highlighted that such enhanced biological features are related to the lower crystallinity level and increased surface charge of hydroxyapatite, both induced by multiple-ion doping. Specifically, the lattice substitution of Ca2+ with Zn2+ promotes the segregation of Ca2+ and doping Mg2+ cations to a less-ordered surface layer, thus promoting dynamic ion absorption/release acting as bioactive signals for cells and exerting an antiproliferative effect on all tested pathogens. These findings open the design of new biodevices, combining regenerative ability and effective microbial inhibition without using any antibiotic drugs. This is extremely important to circumvent bacterial resistance to antibiotics, which is today considered as one of the biggest threats to global health.

Surface Phenomena Enhancing the Antibacterial and Osteogenic Ability of Nanocrystalline Hydroxyapatite, Activated by Multiple-Ion Doping / Sprio, S.; Preti, L.; Montesi, M.; Panseri, S.; Adamiano, A.; Vandini, A.; Pugno, N. M.; Tampieri, A.. - In: ACS BIOMATERIALS SCIENCE & ENGINEERING. - ISSN 2373-9878. - 5:11(2019), pp. 5947-5959. [10.1021/acsbiomaterials.9b00893]

Surface Phenomena Enhancing the Antibacterial and Osteogenic Ability of Nanocrystalline Hydroxyapatite, Activated by Multiple-Ion Doping

Preti L.;Pugno N. M.;
2019-01-01

Abstract

The present work describes a novel nanocrystalline, multidoped hydroxyapatite featuring excellent eukaryotic versus prokaryotic cell selectivity, attested by excellent osteoinductive character and evaluated with human stem cells, and anti-infective ability, tested against different pathogens. Physicochemical analysis and transmission electron microscopy (TEM)/scanning STEM observations highlighted that such enhanced biological features are related to the lower crystallinity level and increased surface charge of hydroxyapatite, both induced by multiple-ion doping. Specifically, the lattice substitution of Ca2+ with Zn2+ promotes the segregation of Ca2+ and doping Mg2+ cations to a less-ordered surface layer, thus promoting dynamic ion absorption/release acting as bioactive signals for cells and exerting an antiproliferative effect on all tested pathogens. These findings open the design of new biodevices, combining regenerative ability and effective microbial inhibition without using any antibiotic drugs. This is extremely important to circumvent bacterial resistance to antibiotics, which is today considered as one of the biggest threats to global health.
2019
11
Sprio, S.; Preti, L.; Montesi, M.; Panseri, S.; Adamiano, A.; Vandini, A.; Pugno, N. M.; Tampieri, A.
Surface Phenomena Enhancing the Antibacterial and Osteogenic Ability of Nanocrystalline Hydroxyapatite, Activated by Multiple-Ion Doping / Sprio, S.; Preti, L.; Montesi, M.; Panseri, S.; Adamiano, A.; Vandini, A.; Pugno, N. M.; Tampieri, A.. - In: ACS BIOMATERIALS SCIENCE & ENGINEERING. - ISSN 2373-9878. - 5:11(2019), pp. 5947-5959. [10.1021/acsbiomaterials.9b00893]
File in questo prodotto:
File Dimensione Formato  
437-ACSBSE19-Antibacterial-ability-hydroxyapatite-doping.pdf

Solo gestori archivio

Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 6.29 MB
Formato Adobe PDF
6.29 MB Adobe PDF   Visualizza/Apri
sprio2019.pdf

Open Access dal 24/10/2020

Tipologia: Post-print referato (Refereed author’s manuscript)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 6.24 MB
Formato Adobe PDF
6.24 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/247341
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 28
  • ???jsp.display-item.citation.isi??? 26
social impact