Our current scientific abilities do not allow for the synthesis of life in the laboratory. In order to reach this demanding goal, scientists are using cellular mimics of life to gain insight into the origin-of-life and the chemical complexity of biology and bioinspired systems. In the first part of this thesis, I characterize the behavior of prebiotically plausible single-chain lipids that can survive the – presumably – hostile conditions of the prebiotic Earth. Eventually, I aim to provide some answers towards the emergence of Darwinian evolution, and thus life as we know it. In the second part, I demonstrate a bioinspired complex chemical system that can influence the behavior of eukaryotic cells and neurons. This study highlights the plausibility of similar non-living cellular mimics for therapeutic applications.
Mimics of Protocellular and Extant Life / Toparlak, Omer Duhan. - (2019 Oct 21), pp. 1-284. [10.15168/11572_243297]
Titolo: | Mimics of Protocellular and Extant Life | |
Anno di pubblicazione: | 2019-10-21 | |
Ciclo: | XXXI | |
Anno Accademico: | 2017-2018 | |
Struttura: | Dipartimento di Biologia Cellulare, Computazionale e Integrata - CIBIO | |
Corso di dottorato: | Biomolecular Sciences | |
Autori Unitn: | ||
Relatore: | Mansy, Sheref Samir | |
Tesi in cotutela: | no | |
Lingua: | Inglese | |
Digital Object Identifier (DOI): | 10.15168/11572_243297 | |
Appare nelle tipologie: | 08.1 Tesi di dottorato (Doctoral Thesis) |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
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phd_unitn_omerduhan_toparlak.pdf | Main document | Tesi di dottorato (Doctoral Thesis) | Tutti i diritti riservati (All rights reserved) | Open Access Visualizza/Apri |