Tumor purity (TP) is the proportion of cancer cells in a tumor sample. TP impacts on the accurate assessment of molecular and genomics features as assayed with NGS approaches. State-of-the-art tools mainly rely on somatic copy-number alterations (SCNA) to quantify TP and therefore fail when a tumor genome is nearly euploid, i.e. "non-aberrant" in terms of identifiable SCNAs.
TPES: Tumor Purity Estimation from SNVs / Locallo, Alessio; Prandi, Davide; Fedrizzi, Tarcisio; Demichelis, Francesca. - In: BIOINFORMATICS. - ISSN 1367-4803. - 2019:(2019). [10.1093/bioinformatics/btz406]
TPES: Tumor Purity Estimation from SNVs
Prandi, Davide;Fedrizzi, Tarcisio;Demichelis, Francesca
2019-01-01
Abstract
Tumor purity (TP) is the proportion of cancer cells in a tumor sample. TP impacts on the accurate assessment of molecular and genomics features as assayed with NGS approaches. State-of-the-art tools mainly rely on somatic copy-number alterations (SCNA) to quantify TP and therefore fail when a tumor genome is nearly euploid, i.e. "non-aberrant" in terms of identifiable SCNAs.File in questo prodotto:
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