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EnglishEpsins are part of the internalization machinery pivotal to control clathrin-mediated endocytosis. Here, we report that epsin family members are expressed in mouse embryonic stem cells (mESCs) and that epsin1/2 knockdown alters both mESC exits from pluripotency and their differentiation. Furthermore, we show that epsin1/2 knockdown compromises the correct polarization and division of mESC-derived neural progenitors and their conversion into expandable radial glia-like neural stem cells. Finally, we provide evidence that Notch signaling is impaired following epsin1/2 knockdown and that experimental restoration of Notch signaling rescues the epsin-mediated phenotypes. We conclude that epsins contribute to control mESC exit from pluripotency and allow their neural differentiation by appropriate modulation of Notch signaling.
Epsins regulate mouse embryonic stem cell exit from pluripotency and neural commitment by controlling notch activation / Cardano, M.; Zasso, J.; Ruggiero, L.; Di Giacomo, G.; Marcatili, M.; Cremona, O.; Conti, L.. - In: STEM CELLS INTERNATIONAL. - ISSN 1687-966X. - ELETTRONICO. - 2019(2019), p. 4084351. [10.1155/2019/4084351]
| Titolo: | Epsins regulate mouse embryonic stem cell exit from pluripotency and neural commitment by controlling notch activation | |
| Autori: | Cardano, M.; Zasso, J.; Ruggiero, L.; Di Giacomo, G.; Marcatili, M.; Cremona, O.; Conti, L. | |
| Autori Unitn: | ||
| Titolo del periodico: | STEM CELLS INTERNATIONAL | |
| Anno di pubblicazione: | 2019 | |
| Codice identificativo Scopus: | 2-s2.0-85062840815 | |
| Codice identificativo Pubmed: | 30930949 | |
| Codice identificativo WOS: | WOS:000460925100001 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1155/2019/4084351 | |
| Handle: | http://hdl.handle.net/11572/239157 | |
| Citazione: | Epsins regulate mouse embryonic stem cell exit from pluripotency and neural commitment by controlling notch activation / Cardano, M.; Zasso, J.; Ruggiero, L.; Di Giacomo, G.; Marcatili, M.; Cremona, O.; Conti, L.. - In: STEM CELLS INTERNATIONAL. - ISSN 1687-966X. - ELETTRONICO. - 2019(2019), p. 4084351. [10.1155/2019/4084351] | |
| Appare nelle tipologie: | 03.1 Articolo su rivista (Journal article) |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 4084351-1.pdf | Articolo principale | Versione editoriale (Publisher’s layout) |  | Open Access Visualizza/Apri |
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