Background: During its persistence in cystic fibrosis (CF) airways, P. aeruginosa develops a series of phenotypic changes by the accumulation of pathoadaptive mutations. A better understanding of the role of these mutations in the adaptive process, with particular reference to the development of multidrug resistance (MDR), is essential for future development of novel therapeutic approaches, including the identification of new drug targets and the implementation of more efficient antibiotic therapy. Although several whole-genome sequencing studies on P. aeruginosa CF lineages have been published, the evolutionary trajectories in relation to the development of antimicrobial resistance remain mostly unexplored to date. In this study, we monitored the adaptive changes of P. aeruginosa during its microevolution in the CF airways to provide an innovative, genome-wide picture of mutations and persistent phenotypes and to point out potential novel mechanisms allowing survival in CF patients un...

Persistence and Microevolution of Pseudomonas aeruginosa in the Cystic Fibrosis Lung: A Single-Patient Longitudinal Genomic Study / Bianconi, Irene; D’Arcangelo, Silvia; Esposito, Alfonso; Benedet, Mattia; Piffer, Elena; Dinnella, Grazia; Gualdi, Paola; Schinella, Michele; Baldo, Ermanno; Donati, Claudio; Jousson, Olivier. - In: FRONTIERS IN MICROBIOLOGY. - ISSN 1664-302X. - 9:(2019). [10.3389/fmicb.2018.03242]

Persistence and Microevolution of Pseudomonas aeruginosa in the Cystic Fibrosis Lung: A Single-Patient Longitudinal Genomic Study

Bianconi, Irene;Esposito, Alfonso;Benedet, Mattia;Piffer, Elena;Jousson, Olivier
2019-01-01

Abstract

Background: During its persistence in cystic fibrosis (CF) airways, P. aeruginosa develops a series of phenotypic changes by the accumulation of pathoadaptive mutations. A better understanding of the role of these mutations in the adaptive process, with particular reference to the development of multidrug resistance (MDR), is essential for future development of novel therapeutic approaches, including the identification of new drug targets and the implementation of more efficient antibiotic therapy. Although several whole-genome sequencing studies on P. aeruginosa CF lineages have been published, the evolutionary trajectories in relation to the development of antimicrobial resistance remain mostly unexplored to date. In this study, we monitored the adaptive changes of P. aeruginosa during its microevolution in the CF airways to provide an innovative, genome-wide picture of mutations and persistent phenotypes and to point out potential novel mechanisms allowing survival in CF patients un...
2019
Bianconi, Irene; D’Arcangelo, Silvia; Esposito, Alfonso; Benedet, Mattia; Piffer, Elena; Dinnella, Grazia; Gualdi, Paola; Schinella, Michele; Baldo, E...espandi
Persistence and Microevolution of Pseudomonas aeruginosa in the Cystic Fibrosis Lung: A Single-Patient Longitudinal Genomic Study / Bianconi, Irene; D’Arcangelo, Silvia; Esposito, Alfonso; Benedet, Mattia; Piffer, Elena; Dinnella, Grazia; Gualdi, Paola; Schinella, Michele; Baldo, Ermanno; Donati, Claudio; Jousson, Olivier. - In: FRONTIERS IN MICROBIOLOGY. - ISSN 1664-302X. - 9:(2019). [10.3389/fmicb.2018.03242]
File in questo prodotto:
File Dimensione Formato  
Bianconi2019_FrontMicrobiol.pdf

accesso aperto

Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Creative commons
Dimensione 3.84 MB
Formato Adobe PDF
3.84 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/224187
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 27
  • ???jsp.display-item.citation.isi??? 31
  • OpenAlex ND
social impact