Gastritis is a widely spread inflammatory disease, mostly caused by Helicobacter pylori infection. Release of IL-8 by the stomach epithelium is a hallmark of gastritis and contributes to the amplification of the inflammatory state. Pharmacological modulation of IL-8 release is a strategy to relieve gastric inflammation and prevent more severe clinical outcomes. In search of nutraceuticals with potential anti-gastritis properties we used a bio-guided approach based on IL-8 secretion by gastric cells to characterize extracts from the fruits of different chestnut varieties. We found that the ability to inhibit IL-8 secretion correlated with the amount of proanthocyanidins and was associated to the not edible parts of chestnut in all the tested varieties. We also found that the anti-inflammatory activity is preserved upon mild thermal treatment and after in vitro simulated gastric digestion. By combining a robust bio-guided approach with a comprehensive analysis of the tannin fraction of chestnut extracts, we provide evidence for the potential use of chestnut-based nutraceuticals in human gastritis. The bioactive components of chestnut fruits inhibit IL-8 secretion by impairing NF-κB signaling and by other mechanisms, thus opening new applications of proanthocyanidins for inflammation-based diseases.

A bio-guided approach for the development of a chestnut-based proanthocyanidin-enriched nutraceutical with potential anti-gastritis properties / Sangiovanni, Enrico; Piazza, Stefano; Vrhovsek, Urska; Fumagalli, Marco; Khalilpour, Saba; Masuero, Domenico; Di Lorenzo, Chiara; Colombo, Luca; Mattivi, Fulvio; De Fabiani, Emma; Dell'Agli, Mario. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - ELETTRONICO. - 134:(2018), pp. 145-155. [10.1016/j.phrs.2018.06.016]

A bio-guided approach for the development of a chestnut-based proanthocyanidin-enriched nutraceutical with potential anti-gastritis properties

Vrhovsek, Urska;Masuero, Domenico;Mattivi, Fulvio;
2018

Abstract

Gastritis is a widely spread inflammatory disease, mostly caused by Helicobacter pylori infection. Release of IL-8 by the stomach epithelium is a hallmark of gastritis and contributes to the amplification of the inflammatory state. Pharmacological modulation of IL-8 release is a strategy to relieve gastric inflammation and prevent more severe clinical outcomes. In search of nutraceuticals with potential anti-gastritis properties we used a bio-guided approach based on IL-8 secretion by gastric cells to characterize extracts from the fruits of different chestnut varieties. We found that the ability to inhibit IL-8 secretion correlated with the amount of proanthocyanidins and was associated to the not edible parts of chestnut in all the tested varieties. We also found that the anti-inflammatory activity is preserved upon mild thermal treatment and after in vitro simulated gastric digestion. By combining a robust bio-guided approach with a comprehensive analysis of the tannin fraction of chestnut extracts, we provide evidence for the potential use of chestnut-based nutraceuticals in human gastritis. The bioactive components of chestnut fruits inhibit IL-8 secretion by impairing NF-κB signaling and by other mechanisms, thus opening new applications of proanthocyanidins for inflammation-based diseases.
Sangiovanni, Enrico; Piazza, Stefano; Vrhovsek, Urska; Fumagalli, Marco; Khalilpour, Saba; Masuero, Domenico; Di Lorenzo, Chiara; Colombo, Luca; Mattivi, Fulvio; De Fabiani, Emma; Dell'Agli, Mario
A bio-guided approach for the development of a chestnut-based proanthocyanidin-enriched nutraceutical with potential anti-gastritis properties / Sangiovanni, Enrico; Piazza, Stefano; Vrhovsek, Urska; Fumagalli, Marco; Khalilpour, Saba; Masuero, Domenico; Di Lorenzo, Chiara; Colombo, Luca; Mattivi, Fulvio; De Fabiani, Emma; Dell'Agli, Mario. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - ELETTRONICO. - 134:(2018), pp. 145-155. [10.1016/j.phrs.2018.06.016]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11572/210749
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