B-lines are ultrasound-imaging artifacts, which correlate with several lung-pathologies. However, their understanding and characterization is still largely incomplete. To further study B-lines, lung-phantoms were developed by trapping a layer of microbubbles in tissue-mimicking gel. To simulate the alveolar size reduction typical of various pathologies, 170 and 80 µm bubbles were used for phantom-type 1 and 2, respectively. A normal alveolar diameter is approximately 280 µm. A LA332 linear-array connected to the ULA-OP platform was used for imaging. Standard ultrasound (US) imaging at 4.5 MHz was performed. Subsequently, a multi-frequency approach was used where images were sequentially generated using orthogonal sub-bands centered at different frequencies (3, 4, 5, and 6 MHz). Results show that B-lines appear predominantly with phantom-type 2. Moreover, the multi-frequency approach revealed that the B-lines originate from a specific portion of the US spectrum. These results can give rise to significant clinical applications since, if further confirmed by extensive in-vivo studies, the native frequency of B-lines could provide a quantitative-measure of the state of the lung.

Determination of a potential quantitative measure of the state of the lung using lung ultrasound spectroscopy / Demi, Libertario; Van Hoeve, Wim; Van Sloun, Ruud J. G.; Soldati, Gino; Demi, Marcello. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 7:1(2017), pp. 12746.1-12746.7. [10.1038/s41598-017-13078-9]

Determination of a potential quantitative measure of the state of the lung using lung ultrasound spectroscopy

Demi, Libertario;
2017-01-01

Abstract

B-lines are ultrasound-imaging artifacts, which correlate with several lung-pathologies. However, their understanding and characterization is still largely incomplete. To further study B-lines, lung-phantoms were developed by trapping a layer of microbubbles in tissue-mimicking gel. To simulate the alveolar size reduction typical of various pathologies, 170 and 80 µm bubbles were used for phantom-type 1 and 2, respectively. A normal alveolar diameter is approximately 280 µm. A LA332 linear-array connected to the ULA-OP platform was used for imaging. Standard ultrasound (US) imaging at 4.5 MHz was performed. Subsequently, a multi-frequency approach was used where images were sequentially generated using orthogonal sub-bands centered at different frequencies (3, 4, 5, and 6 MHz). Results show that B-lines appear predominantly with phantom-type 2. Moreover, the multi-frequency approach revealed that the B-lines originate from a specific portion of the US spectrum. These results can give rise to significant clinical applications since, if further confirmed by extensive in-vivo studies, the native frequency of B-lines could provide a quantitative-measure of the state of the lung.
2017
1
Demi, Libertario; Van Hoeve, Wim; Van Sloun, Ruud J. G.; Soldati, Gino; Demi, Marcello
Determination of a potential quantitative measure of the state of the lung using lung ultrasound spectroscopy / Demi, Libertario; Van Hoeve, Wim; Van Sloun, Ruud J. G.; Soldati, Gino; Demi, Marcello. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 7:1(2017), pp. 12746.1-12746.7. [10.1038/s41598-017-13078-9]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/209520
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