The traditional use of extracts of Euphrasia rostkoviana to relieve ocular inflammation or infections is well documented and supported by clinical studies. Various classes of chemical compounds such as iridoids, phenylethanoids, flavonoids and hydroxycinnamic acids have been reported. The present work aims to assess the chemical diversity among seven populations of Euphrasia rostkoviana found in northern Italy. A meticulous separation of components led to the isolation and structural characterization of two previously unrecorded phenylethanoids methoxycrassifolioside and deoxycrassifolioside and one previously undescribed terpene glucoside (1E,6E)-8-hydroxy-3,7-dimethyl-octa-1,6-dienyl 1-O-b-D-glucopyranoside. We have also identified known phenylethanoids and iridoids that are reported in this genus for the first time. Finally, a targeted quantitative analysis for the standardization of herbal preparations revealed that iridoids occur in all populations whereas the presence and the levels of rutin and phenylethanoids are highly variable.

Research survey on iridoid and phenylethanoid glycosides among seven populations of Euphrasia rostkoviana Hayne from the Alps / Mari, Angela; Ciocarlan, Alexandru; Aiello, Nicola; Scartezzini, Fabrizio; Pizza, Cosimo; D'Ambrosio, Michele. - In: PHYTOCHEMISTRY. - ISSN 0031-9422. - 137:(2017), pp. 72-80. [10.1016/j.phytochem.2017.02.013]

Research survey on iridoid and phenylethanoid glycosides among seven populations of Euphrasia rostkoviana Hayne from the Alps

D'Ambrosio, Michele
2017-01-01

Abstract

The traditional use of extracts of Euphrasia rostkoviana to relieve ocular inflammation or infections is well documented and supported by clinical studies. Various classes of chemical compounds such as iridoids, phenylethanoids, flavonoids and hydroxycinnamic acids have been reported. The present work aims to assess the chemical diversity among seven populations of Euphrasia rostkoviana found in northern Italy. A meticulous separation of components led to the isolation and structural characterization of two previously unrecorded phenylethanoids methoxycrassifolioside and deoxycrassifolioside and one previously undescribed terpene glucoside (1E,6E)-8-hydroxy-3,7-dimethyl-octa-1,6-dienyl 1-O-b-D-glucopyranoside. We have also identified known phenylethanoids and iridoids that are reported in this genus for the first time. Finally, a targeted quantitative analysis for the standardization of herbal preparations revealed that iridoids occur in all populations whereas the presence and the levels of rutin and phenylethanoids are highly variable.
2017
Mari, Angela; Ciocarlan, Alexandru; Aiello, Nicola; Scartezzini, Fabrizio; Pizza, Cosimo; D'Ambrosio, Michele
Research survey on iridoid and phenylethanoid glycosides among seven populations of Euphrasia rostkoviana Hayne from the Alps / Mari, Angela; Ciocarlan, Alexandru; Aiello, Nicola; Scartezzini, Fabrizio; Pizza, Cosimo; D'Ambrosio, Michele. - In: PHYTOCHEMISTRY. - ISSN 0031-9422. - 137:(2017), pp. 72-80. [10.1016/j.phytochem.2017.02.013]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/197475
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