A gene-directed chemical communication pathway between synthetic protocell signaling transmitters (lipid vesicles) and receivers (proteinosomes) was designed, built and tested using a bottom-up modular approach comprising small molecule transcriptional control, cell-free gene expression, porin-directed efflux, substrate signaling, and enzyme cascade-mediated processing.
Gene-Mediated Chemical Communication in Synthetic Protocell Communities / Tang, T-Y Dora; Cecchi, Dario; Fracasso, Giorgio; Accardi, Davide; Coutable-Pennarun, Angelique; Mansy, Sheref S; Perriman, Adam W; Anderson, J L Ross; Mann, Stephen. - In: ACS SYNTHETIC BIOLOGY. - ISSN 2161-5063. - 7:(2018), pp. 339-346. [10.1021/acssynbio.7b00306]
Gene-Mediated Chemical Communication in Synthetic Protocell Communities
Cecchi, Dario;Mansy, Sheref S;
2018-01-01
Abstract
A gene-directed chemical communication pathway between synthetic protocell signaling transmitters (lipid vesicles) and receivers (proteinosomes) was designed, built and tested using a bottom-up modular approach comprising small molecule transcriptional control, cell-free gene expression, porin-directed efflux, substrate signaling, and enzyme cascade-mediated processing.| File | Dimensione | Formato | |
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Main_text_and_materials_and_figures_working_draft_1.pdf
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