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EnglishSilicon oxynitride (SiON) microring resonators areused to develop a biosensor device to detect Aflatoxin M1 (AFM1),a carcinogenic mycotoxin present in milk. Two different surfacefunctionalization strategies are tested to realize an affinity biosens-ing device. Both strategies are based on the formation of a silanesurface layer able to bind either specific DNA-aptamers or anti-gen binding fragments (Fab’). The sensing device consists of anarray of four SiON microring resonators, fiber-coupled to a verti-cal cavity surface emitting laser operating at 850 nm. Detection isrealized with off-chip silicon photodetectors. With both function-alizations, we demonstrate a specific detection of AFM1 in buffer,while the nonspecific detection of Ochratoxin is not occurring. Re-peatability and reproducibility of both functionalization strategiesare discussed.
Aptamer- and Fab’- functionalized microring resonators for Aflatoxin M1 detection / Chalyan, Tatevik; Pasquardini, Laura; Gandolfi, Davide; Guider, Romain; Samusenko, Alina; Zanetti, Manuela; Pucker, Georg; Pederzolli, Cecilia; Pavesi, Lorenzo. - In: IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS. - ISSN 1077-260X. - 23:2(2017), pp. 5900208.1-5900208.8.
| Titolo: | Aptamer- and Fab’- functionalized microring resonators for Aflatoxin M1 detection |
| Autori: | Chalyan, Tatevik; Pasquardini, Laura; Gandolfi, Davide; Guider, Romain; Samusenko, Alina; Zanetti, Manuela; Pucker, Georg; Pederzolli, Cecilia; Pavesi, Lorenzo |
| Autori Unitn: | |
| Titolo del periodico: | IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS |
| Anno di pubblicazione: | 2017 |
| Numero e parte del fascicolo: | 2 |
| Codice identificativo Scopus: | 2-s2.0-84994803393 |
| Codice identificativo ISI: | WOS:000386236400001 |
| Handle: | http://hdl.handle.net/11572/192223 |
| Citazione: | Aptamer- and Fab’- functionalized microring resonators for Aflatoxin M1 detection / Chalyan, Tatevik; Pasquardini, Laura; Gandolfi, Davide; Guider, Romain; Samusenko, Alina; Zanetti, Manuela; Pucker, Georg; Pederzolli, Cecilia; Pavesi, Lorenzo. - In: IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS. - ISSN 1077-260X. - 23:2(2017), pp. 5900208.1-5900208.8. |
| Appare nelle tipologie: | 03.1 Articolo su rivista (Journal article) |
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http://hdl.handle.net/11572/192223
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