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EnglishA new beta-lactamase that hydrolyses methicillin was found in the membrane fraction of two clinical isolates of Staphylococcus aureus with borderline susceptibility to this drug. 'Methicillinase' activity was detected in renatured sodium dodecyl sulfate polyacrylamide gel electrophoretograms of staphylococcal membrane proteins. The enzyme activity appeared to be inducible and was more easily detected using penicillin G (or methicillin) rather than nitrocefin as substrate. Similar activity was not detected in the membrane fraction of a methicillin-susceptible strain. These results suggest that, in the two borderline susceptible strains, rather than a hyperproduction of the penicillinase a specific methicillin-hydrolysing activity is responsible for the borderline susceptible phenotype
Evidence for a methicillin-hydrolyzing beta-lactamase in Staphylococcus aureus strains with borderline susceptibility to this drug / Massidda, Orietta; Montanari, M. P.; Varaldo, P. E.. - In: FEMS MICROBIOLOGY LETTERS. - ISSN 0378-1097. - 92:3(1992), pp. 223-228. [10.1111/j.1574-6968.1992.tb05265.x]
| Titolo: | Evidence for a methicillin-hydrolyzing beta-lactamase in Staphylococcus aureus strains with borderline susceptibility to this drug | |
| Autori: | Massidda, Orietta; Montanari, M. P.; Varaldo, P. E. | |
| Autori Unitn: | ||
| Titolo del periodico: | FEMS MICROBIOLOGY LETTERS | |
| Anno di pubblicazione: | 1992 | |
| Numero e parte del fascicolo: | 3 | |
| Codice identificativo Scopus: | 2-s2.0-0034669389 | |
| Codice identificativo WOS: | WOS:A1992HR63900003 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/j.1574-6968.1992.tb05265.x | |
| Handle: | http://hdl.handle.net/11572/187559 | |
| Citazione: | Evidence for a methicillin-hydrolyzing beta-lactamase in Staphylococcus aureus strains with borderline susceptibility to this drug / Massidda, Orietta; Montanari, M. P.; Varaldo, P. E.. - In: FEMS MICROBIOLOGY LETTERS. - ISSN 0378-1097. - 92:3(1992), pp. 223-228. [10.1111/j.1574-6968.1992.tb05265.x] | |
| Appare nelle tipologie: | 03.1 Articolo su rivista (Journal article) |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Massidda et al_FEMS MLett_1992.pdf | Versione editoriale (Publisher’s layout) | Tutti i diritti riservati (All rights reserved) | Administrator |
http://hdl.handle.net/11572/187559
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