Neoplastic overgrowth depends on the cooperation of several mutations ultimately leading to major rearrangements in cellular behaviour. Precancerous cells are often removed by cell death from normal tissues in the early steps of the tumourigenic process, but the molecules responsible for such a fundamental safeguard process remain in part elusive. With the aim to investigate the molecular crosstalk occurring between precancerous and normal cells in vivo, we took advantage of the clonal analysis methods that are available in Drosophila for studying the phenotypes due to lethal giant larvae (lgl) neoplastic mutation induced in different backgrounds and tissues.

The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy / Froldi, F.; Ziosi, Marcello; G., Flavio; Pession, A.; Grzeschik, N. A; Bellosta, Paola; Strand, D.; Richardson, H. E; Pession, A.; Grifoni, D.. - In: BMC BIOLOGY. - ISSN 1741-7007. - STAMPA. - 8:(2010), p. 33. [10.1186/1741-7007-8-33]

The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy

Bellosta, Paola;
2010-01-01

Abstract

Neoplastic overgrowth depends on the cooperation of several mutations ultimately leading to major rearrangements in cellular behaviour. Precancerous cells are often removed by cell death from normal tissues in the early steps of the tumourigenic process, but the molecules responsible for such a fundamental safeguard process remain in part elusive. With the aim to investigate the molecular crosstalk occurring between precancerous and normal cells in vivo, we took advantage of the clonal analysis methods that are available in Drosophila for studying the phenotypes due to lethal giant larvae (lgl) neoplastic mutation induced in different backgrounds and tissues.
2010
Froldi, F.; Ziosi, Marcello; G., Flavio; Pession, A.; Grzeschik, N. A; Bellosta, Paola; Strand, D.; Richardson, H. E; Pession, A.; Grifoni, D....espandi
The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy / Froldi, F.; Ziosi, Marcello; G., Flavio; Pession, A.; Grzeschik, N. A; Bellosta, Paola; Strand, D.; Richardson, H. E; Pession, A.; Grifoni, D.. - In: BMC BIOLOGY. - ISSN 1741-7007. - STAMPA. - 8:(2010), p. 33. [10.1186/1741-7007-8-33]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/187213
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