The charged particle community is looking for techniques exploiting proton interactions instead of X-ray absorption for creating images of human tissue. Due to multiple Coulomb scattering inside the measured object it has shown to be highly non-trivial to achieve sufficient spatial resolution. We present imaging of biological tissue with a proton microscope. This device relies on magnetic optics, distinguishing it from most published proton imaging methods. For these methods reducing the data acquisition time to a clinically acceptable level has turned out to be challenging. In a proton microscope, data acquisition and processing are much simpler. This device even allows imaging in real time. The primary medical application will be image guidance in proton radiosurgery. Proton images demonstrating the potential for this application are presented. Tomographic reconstructions are included to raise awareness of the possibility of high-resolution proton tomography using magneto-optics.

High-energy proton imaging for biomedical applications / Prall, M; Durante, Marco; Berger, T; Przybyla, B; Graeff, C; Lang, P. M; La Tessa, Chiara; Shestov, L; Simoniello, P; Danly, C; Mariam, F; Merrill, F; Nedrow, P; Wilde, C; Varentsov, D.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 6:1(2016), p. 27651. [10.1038/srep27651]

High-energy proton imaging for biomedical applications

Durante, Marco;La Tessa, Chiara;
2016-01-01

Abstract

The charged particle community is looking for techniques exploiting proton interactions instead of X-ray absorption for creating images of human tissue. Due to multiple Coulomb scattering inside the measured object it has shown to be highly non-trivial to achieve sufficient spatial resolution. We present imaging of biological tissue with a proton microscope. This device relies on magnetic optics, distinguishing it from most published proton imaging methods. For these methods reducing the data acquisition time to a clinically acceptable level has turned out to be challenging. In a proton microscope, data acquisition and processing are much simpler. This device even allows imaging in real time. The primary medical application will be image guidance in proton radiosurgery. Proton images demonstrating the potential for this application are presented. Tomographic reconstructions are included to raise awareness of the possibility of high-resolution proton tomography using magneto-optics.
2016
1
Prall, M; Durante, Marco; Berger, T; Przybyla, B; Graeff, C; Lang, P. M; La Tessa, Chiara; Shestov, L; Simoniello, P; Danly, C; Mariam, F; Merrill, F;...espandi
High-energy proton imaging for biomedical applications / Prall, M; Durante, Marco; Berger, T; Przybyla, B; Graeff, C; Lang, P. M; La Tessa, Chiara; Shestov, L; Simoniello, P; Danly, C; Mariam, F; Merrill, F; Nedrow, P; Wilde, C; Varentsov, D.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 6:1(2016), p. 27651. [10.1038/srep27651]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/181842
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 22
  • OpenAlex ND
social impact