Aerial parts of Linaria reflexa, used in North African folk medicine for treating certain skin diseases, were investigated by HPLC-DAD-ESI/MS technique able to identify the glycosyl flavonoids pectolinarin (), isolinariin A (), isolinariin B (), linariin (), isolinariin D () and isolinariin E () as the most abundant components in both hydroalcoholic (HAE) and ultrasoundassisted (UAE) exts. profiles. Metabolite , isolated and fully characterized by extensive NMR (NMR) anal., has been very recently reported from L. japonica together with the compd. . Good antioxidant activities (DPPH radical scavenging, b- carotene bleaching and reducing power assays) were obsd. for the exts. The remarkable antidiabetic activity displayed by UAE (300 mg/kg) has yielded the most marked decrease in blood glucose levels of the alloxan diabetic rats (- 72.09%), greater than the effects by the drug glybenclamide (-63.29%). This study reports the first correlation of antidiabetic activity of Linaria sp. exts. with their chem. compn.
Iridoids and anti-inflammatory properties of n-butanol extract of Linaria tingitana Boiss. & Reut / Hanfer, M.; Cheriet, T.; Ameddah, S.; Mancini, I.; Seghiri, R.; Menad, A.; Benayache, S.; Benayache, F.. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - STAMPA. - 2017:(2017), pp. 1-8. [10.1080/14786419.2016.1272111]
Iridoids and anti-inflammatory properties of n-butanol extract of Linaria tingitana Boiss. & Reut
Cheriet, T.;Mancini, I.;
2017-01-01
Abstract
Aerial parts of Linaria reflexa, used in North African folk medicine for treating certain skin diseases, were investigated by HPLC-DAD-ESI/MS technique able to identify the glycosyl flavonoids pectolinarin (), isolinariin A (), isolinariin B (), linariin (), isolinariin D () and isolinariin E () as the most abundant components in both hydroalcoholic (HAE) and ultrasoundassisted (UAE) exts. profiles. Metabolite , isolated and fully characterized by extensive NMR (NMR) anal., has been very recently reported from L. japonica together with the compd. . Good antioxidant activities (DPPH radical scavenging, b- carotene bleaching and reducing power assays) were obsd. for the exts. The remarkable antidiabetic activity displayed by UAE (300 mg/kg) has yielded the most marked decrease in blood glucose levels of the alloxan diabetic rats (- 72.09%), greater than the effects by the drug glybenclamide (-63.29%). This study reports the first correlation of antidiabetic activity of Linaria sp. exts. with their chem. compn.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione
