Iridoids and anti-inflammatory properties of n-butanol extract of Linaria tingitana Boiss. & Reut

Aerial parts of Linaria reflexa, used in North African folk medicine for treating certain skin diseases, were investigated by HPLC-DAD-ESI/MS technique able to identify the glycosyl flavonoids pectolinarin (), isolinariin A (), isolinariin B (), linariin (), isolinariin D () and isolinariin E () as the most abundant components in both hydroalcoholic (HAE) and ultrasoundassisted (UAE) exts. profiles. Metabolite , isolated and fully characterized by extensive NMR (NMR) anal., has been very recently reported from L. japonica together with the compd. . Good antioxidant activities (DPPH radical scavenging, b- carotene bleaching and reducing power assays) were obsd. for the exts. The remarkable antidiabetic activity displayed by UAE (300 mg/kg) has yielded the most marked decrease in blood glucose levels of the alloxan diabetic rats (- 72.09%), greater than the effects by the drug glybenclamide (-63.29%). This study reports the first correlation of antidiabetic activity of Linaria sp. exts. with their chem. compn.