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EnglishPeripheral blood mononuclear cells (PBMCs) were collected from a patient with treatment-refractory Schizophrenia who presented an exceptional clinical response to Clozapine. iPSC lines were established with a non-integrating reprogramming system based on Sendai virus. A footprint-free hiPSC line was characterized to confirm the expression of the main endogenous pluripotency markers and have a regular karyotype. Pluripotency was confirmed by differentiation into cells belonging to the three germ layers. This hiPSC line represents a valuable tool to study the molecular, biochemical and electrophysiological properties of mature neuronal populations belonging to Clozapine responder patients with a severe form of Schizophrenia. © 2016 The Authors. Published by Elsevier B.V.
Establishment of an induced pluripotent stem cell (iPSC) line from a patient with Clozapine-responder Schizophrenia / Marcatili, Matteo; Marsoner, Fabio; D'Agostino, Armando; Karnavas, Thodoris; Bottai, Daniele; Scarone, Silvio; Conti, Luciano. - In: STEM CELL RESEARCH. - ISSN 1873-5061. - ELETTRONICO. - 2016, 17:3(2016), pp. 630-633. [10.1016/j.scr.2016.11.009]
| Titolo: | Establishment of an induced pluripotent stem cell (iPSC) line from a patient with Clozapine-responder Schizophrenia | |
| Autori: | Marcatili, Matteo; Marsoner, Fabio; D'Agostino, Armando; Karnavas, Thodoris; Bottai, Daniele; Scarone, Silvio; Conti, Luciano | |
| Autori Unitn: | ||
| Titolo del periodico: | STEM CELL RESEARCH | |
| Anno di pubblicazione: | 2016 | |
| Numero e parte del fascicolo: | 3 | |
| Codice identificativo Scopus: | 2-s2.0-85010817989 | |
| Codice identificativo Pubmed: | 27934596 | |
| Codice identificativo WOS: | WOS:000393191300038 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.scr.2016.11.009 | |
| Handle: | http://hdl.handle.net/11572/174786 | |
| Citazione: | Establishment of an induced pluripotent stem cell (iPSC) line from a patient with Clozapine-responder Schizophrenia / Marcatili, Matteo; Marsoner, Fabio; D'Agostino, Armando; Karnavas, Thodoris; Bottai, Daniele; Scarone, Silvio; Conti, Luciano. - In: STEM CELL RESEARCH. - ISSN 1873-5061. - ELETTRONICO. - 2016, 17:3(2016), pp. 630-633. [10.1016/j.scr.2016.11.009] | |
| Appare nelle tipologie: | 03.1 Articolo su rivista (Journal article) |
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