Peripheral blood mononuclear cells (PBMCs) were collected from a patient with treatment-refractory Schizophrenia who presented an exceptional clinical response to Clozapine. iPSC lines were established with a non-integrating reprogramming system based on Sendai virus. A footprint-free hiPSC line was characterized to confirm the expression of the main endogenous pluripotency markers and have a regular karyotype. Pluripotency was confirmed by differentiation into cells belonging to the three germ layers. This hiPSC line represents a valuable tool to study the molecular, biochemical and electrophysiological properties of mature neuronal populations belonging to Clozapine responder patients with a severe form of Schizophrenia. © 2016 The Authors. Published by Elsevier B.V.

Establishment of an induced pluripotent stem cell (iPSC) line from a patient with Clozapine-responder Schizophrenia / Marcatili, Matteo; Marsoner, Fabio; D'Agostino, Armando; Karnavas, Thodoris; Bottai, Daniele; Scarone, Silvio; Conti, Luciano. - In: STEM CELL RESEARCH. - ISSN 1873-5061. - ELETTRONICO. - 2016, 17:3(2016), pp. 630-633. [10.1016/j.scr.2016.11.009]

Establishment of an induced pluripotent stem cell (iPSC) line from a patient with Clozapine-responder Schizophrenia

Conti, Luciano
2016

Abstract

Peripheral blood mononuclear cells (PBMCs) were collected from a patient with treatment-refractory Schizophrenia who presented an exceptional clinical response to Clozapine. iPSC lines were established with a non-integrating reprogramming system based on Sendai virus. A footprint-free hiPSC line was characterized to confirm the expression of the main endogenous pluripotency markers and have a regular karyotype. Pluripotency was confirmed by differentiation into cells belonging to the three germ layers. This hiPSC line represents a valuable tool to study the molecular, biochemical and electrophysiological properties of mature neuronal populations belonging to Clozapine responder patients with a severe form of Schizophrenia. © 2016 The Authors. Published by Elsevier B.V.
3
Marcatili, Matteo; Marsoner, Fabio; D'Agostino, Armando; Karnavas, Thodoris; Bottai, Daniele; Scarone, Silvio; Conti, Luciano
Establishment of an induced pluripotent stem cell (iPSC) line from a patient with Clozapine-responder Schizophrenia / Marcatili, Matteo; Marsoner, Fabio; D'Agostino, Armando; Karnavas, Thodoris; Bottai, Daniele; Scarone, Silvio; Conti, Luciano. - In: STEM CELL RESEARCH. - ISSN 1873-5061. - ELETTRONICO. - 2016, 17:3(2016), pp. 630-633. [10.1016/j.scr.2016.11.009]
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S1873506116301763-main.pdf

accesso aperto

Descrizione: Articolo principale
Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Creative commons
Dimensione 539.31 kB
Formato Adobe PDF
539.31 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/174786
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 5
social impact