Identifying accurate biomarkers of cognitive decline is essential for advancing early diagnosis and prevention therapies in Alzheimer's disease. The Alzheimer's disease DREAM Challenge was designed as a computational crowdsourced project to benchmark the current state-of-the-art in predicting cognitive outcomes in Alzheimer's disease based on high dimensional, publicly available genetic and structural imaging data. This meta-analysis failed to identify a meaningful predictor developed from either data modality, suggesting that alternate approaches should be considered for prediction of cognitive performance. © 2016 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease / Allen, G.I., Amoroso, N., Anghel, C., Balagurusamy, V., Bare, C.J., Beaton, D., Bellotti, R., Bennett, D.A., Boehme, K.L., Boutros, P.C., Caberlotto, L., Caloian, C., Campbell, F., Chaibub Neto, E., Chang, Y.C., Chen, B., Chen, C.Y., Chien, T.Y., Clark, T., Das, S., et al.. - In: ALZHEIMER'S & DEMENTIA. - ISSN 1552-5260. - 12:6(2016), pp. 645-653. [10.1016/j.jalz.2016.02.006]
Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease
Lauria, Mario;Priami, Corrado;
2016-01-01
Abstract
Identifying accurate biomarkers of cognitive decline is essential for advancing early diagnosis and prevention therapies in Alzheimer's disease. The Alzheimer's disease DREAM Challenge was designed as a computational crowdsourced project to benchmark the current state-of-the-art in predicting cognitive outcomes in Alzheimer's disease based on high dimensional, publicly available genetic and structural imaging data. This meta-analysis failed to identify a meaningful predictor developed from either data modality, suggesting that alternate approaches should be considered for prediction of cognitive performance. © 2016 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).| File | Dimensione | Formato | |
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