Disrupted differentiation during development can lead to oncogenesis, but the underlying mechanisms remain poorly understood. Here we identify BCL6, a transcriptional repressor and lymphoma oncoprotein, as a pivotal factor required for neurogenesis and tumor suppression of medulloblastoma (MB). BCL6 is necessary for and capable of preventing the development of GNP-derived MB in mice, and can block the growth of humanMBcells in vitro. BCL6 neurogenic and oncosuppressor effects rely on direct transcriptional repression of Gli1 and Gli2 effectors of the SHH pathway, through recruitment of BCOR corepressor and SIRT1 deacetylase. Our findings identify the BCL6/BCOR/SIRT1 complex as a potent repressor of the SHH pathway in normal and oncogenic neural development, with direct diagnostic and/or therapeutic relevance for SHH MB.

A BCL6/BCOR/SIRT1 Complex Triggers Neurogenesis and Suppresses Medulloblastoma by Repressing Sonic Hedgehog Signaling / Tiberi, Luca; Bonnefont, Jérôme; Van den Ameele, Jelle; Le Bon, Serge-Daniel; Herpoel, Adèle; Bilheu, Angéline; Baron, Beverly W.; Vanderhaeghen, Pierre. - In: CANCER CELL. - ISSN 1535-6108. - ELETTRONICO. - 26:6(2014), pp. 797-812. [10.1016/j.ccell.2014.10.021]

A BCL6/BCOR/SIRT1 Complex Triggers Neurogenesis and Suppresses Medulloblastoma by Repressing Sonic Hedgehog Signaling

Tiberi, Luca;
2014

Abstract

Disrupted differentiation during development can lead to oncogenesis, but the underlying mechanisms remain poorly understood. Here we identify BCL6, a transcriptional repressor and lymphoma oncoprotein, as a pivotal factor required for neurogenesis and tumor suppression of medulloblastoma (MB). BCL6 is necessary for and capable of preventing the development of GNP-derived MB in mice, and can block the growth of humanMBcells in vitro. BCL6 neurogenic and oncosuppressor effects rely on direct transcriptional repression of Gli1 and Gli2 effectors of the SHH pathway, through recruitment of BCOR corepressor and SIRT1 deacetylase. Our findings identify the BCL6/BCOR/SIRT1 complex as a potent repressor of the SHH pathway in normal and oncogenic neural development, with direct diagnostic and/or therapeutic relevance for SHH MB.
6
Tiberi, Luca; Bonnefont, Jérôme; Van den Ameele, Jelle; Le Bon, Serge-Daniel; Herpoel, Adèle; Bilheu, Angéline; Baron, Beverly W.; Vanderhaeghen, Pierre
A BCL6/BCOR/SIRT1 Complex Triggers Neurogenesis and Suppresses Medulloblastoma by Repressing Sonic Hedgehog Signaling / Tiberi, Luca; Bonnefont, Jérôme; Van den Ameele, Jelle; Le Bon, Serge-Daniel; Herpoel, Adèle; Bilheu, Angéline; Baron, Beverly W.; Vanderhaeghen, Pierre. - In: CANCER CELL. - ISSN 1535-6108. - ELETTRONICO. - 26:6(2014), pp. 797-812. [10.1016/j.ccell.2014.10.021]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11572/149458
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