n Motor Neglect (MN) syndrome, a specific impairment in non-congruent bimanual movements has been described. In the present case-control study, we investigated the neuro-functional correlates of this behavioral deficit. Two right-brain-damaged (RBD) patients, one with (MN+) and one without (MN−) MN, were evaluated by means of functional Magnetic Resonance Imaging (fMRI) in a bimanual Circles-Lines (CL) paradigm. Patients were requested to perform right-hand movements (lines-drawing) and, simultaneously, congruent (lines-drawing) or non-congruent (circles-drawing) left-hand movements. In the behavioral task, MN− patient showed a bimanual-coupling-effect, while MN+ patient did not. The fMRI study showed that in MN−, a fronto-parietal network, mainly involving the pre-supplementary motor area (pre-SMA) and the posterior parietal cortex (PPC), was significantly more active in non-congruent than in congruent conditions, as previously shown in healthy subjects. On the contrary, MN+ patient showed an opposite pattern of activation both in pre-SMA and in PPC. Within this fronto-parietal network, the pre-SMA is supposed to exert an inhibitory influence on the default coupling of homologous muscles, thus allowing the execution of non-congruent movements. In MN syndrome, the described abnormal pre-SMA activity supports the hypothesis that a failure to inhibit ipsilesional motor programs might determine a specific impairment of non-congruent movements.

Bimanual non-congruent actions in motor neglect syndrome: a combined behavioral/fMRI study / Garbarini, F.; Turella, Luca; Rabuffetti, M. .; Cantagallo, A. .; Piedimonte, A.; Fainardi, E.; Berti, A.; Fadiga, L.. - In: FRONTIERS IN HUMAN NEUROSCIENCE. - ISSN 1662-5161. - 2015:(2015).

Bimanual non-congruent actions in motor neglect syndrome: a combined behavioral/fMRI study

Turella, Luca;
2015-01-01

Abstract

n Motor Neglect (MN) syndrome, a specific impairment in non-congruent bimanual movements has been described. In the present case-control study, we investigated the neuro-functional correlates of this behavioral deficit. Two right-brain-damaged (RBD) patients, one with (MN+) and one without (MN−) MN, were evaluated by means of functional Magnetic Resonance Imaging (fMRI) in a bimanual Circles-Lines (CL) paradigm. Patients were requested to perform right-hand movements (lines-drawing) and, simultaneously, congruent (lines-drawing) or non-congruent (circles-drawing) left-hand movements. In the behavioral task, MN− patient showed a bimanual-coupling-effect, while MN+ patient did not. The fMRI study showed that in MN−, a fronto-parietal network, mainly involving the pre-supplementary motor area (pre-SMA) and the posterior parietal cortex (PPC), was significantly more active in non-congruent than in congruent conditions, as previously shown in healthy subjects. On the contrary, MN+ patient showed an opposite pattern of activation both in pre-SMA and in PPC. Within this fronto-parietal network, the pre-SMA is supposed to exert an inhibitory influence on the default coupling of homologous muscles, thus allowing the execution of non-congruent movements. In MN syndrome, the described abnormal pre-SMA activity supports the hypothesis that a failure to inhibit ipsilesional motor programs might determine a specific impairment of non-congruent movements.
2015
Garbarini, F.; Turella, Luca; Rabuffetti, M. .; Cantagallo, A. .; Piedimonte, A.; Fainardi, E.; Berti, A.; Fadiga, L.
Bimanual non-congruent actions in motor neglect syndrome: a combined behavioral/fMRI study / Garbarini, F.; Turella, Luca; Rabuffetti, M. .; Cantagallo, A. .; Piedimonte, A.; Fainardi, E.; Berti, A.; Fadiga, L.. - In: FRONTIERS IN HUMAN NEUROSCIENCE. - ISSN 1662-5161. - 2015:(2015).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/148775
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