The shape recognition model of olfaction maintains that odorant reception probes physicochemical properties such as size, shape, electric charge and hydrophobicity of the ligand. Recently, insects were shown to distinguish common from deuterated isotopomers of the same odorant, suggesting the involvement of other molecular properties to odorant reception. Via two-photon functional microscopy we investigated how common and deuterated isoforms of natural odorants are coded within the honeybee brain. Our results provide evidence that (i) different isotopomers generate different neuronal activation maps, (ii) isotopomer sensitivity is a general mechanism common to multiple odorant receptors and (iii) isotopomer specificity is highly consistent across individuals. This indicates that honeybee’s olfactory system discriminates between isotopomers of the same odorant, suggesting that other features, such as molecular vibrations, may contribute to odour signal transduction.

Differential Odour Coding of Isotopomers in the Honeybee Brain / Paoli, Marco; Anesi, Andrea; Antolini, Renzo; Guella, Graziano; Vallortigara, Giorgio; Haase, Albrecht. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - ELETTRONICO. - 6:(2016), pp. 2189301-2189310. [10.1038/srep21893]

Differential Odour Coding of Isotopomers in the Honeybee Brain

Paoli, Marco;Anesi, Andrea;Antolini, Renzo;Guella, Graziano;Vallortigara, Giorgio;Haase, Albrecht
2016-01-01

Abstract

The shape recognition model of olfaction maintains that odorant reception probes physicochemical properties such as size, shape, electric charge and hydrophobicity of the ligand. Recently, insects were shown to distinguish common from deuterated isotopomers of the same odorant, suggesting the involvement of other molecular properties to odorant reception. Via two-photon functional microscopy we investigated how common and deuterated isoforms of natural odorants are coded within the honeybee brain. Our results provide evidence that (i) different isotopomers generate different neuronal activation maps, (ii) isotopomer sensitivity is a general mechanism common to multiple odorant receptors and (iii) isotopomer specificity is highly consistent across individuals. This indicates that honeybee’s olfactory system discriminates between isotopomers of the same odorant, suggesting that other features, such as molecular vibrations, may contribute to odour signal transduction.
2016
Paoli, Marco; Anesi, Andrea; Antolini, Renzo; Guella, Graziano; Vallortigara, Giorgio; Haase, Albrecht
Differential Odour Coding of Isotopomers in the Honeybee Brain / Paoli, Marco; Anesi, Andrea; Antolini, Renzo; Guella, Graziano; Vallortigara, Giorgio; Haase, Albrecht. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - ELETTRONICO. - 6:(2016), pp. 2189301-2189310. [10.1038/srep21893]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/147571
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