BACKGROUND: Anodal transcranial direct current stimulation (A-tDCS) is a non-invasive technique in which cortical polarization can be used to increase excitability and facilitate learning through the modulation of neuroplasticity. Although the facilitatory effects of A-tDCS are well documented, there is evidence that they are not always present and may even be reversed during task execution. OBJECTIVE: In this study, we explored the interaction between A-tDCS and task execution. We aimed to test how the excitability induced by the task interacts with the excitability induced by A-tDCS and determines the behavioral outcome. METHODS: We performed an experiment in which A-tDCS or a control stimulation (Ctrl) were combined with one of two motor practices (MP), one inducing learning and increasing cortical excitability (F-MP) and the other neither inducing learning nor changing cortical excitability (S-MP). Six blocks of MP were performed while the primary motor cortex was stimulated. Moreover, one block of F-MP was performed before the stimulation (baseline) and one after. In an additional experiment, motor evoked potentials (MEPs) were recorded before the baseline block (TMS-pre) and after the MP (TMS-post). RESULTS: We observed that A-tDCS reduced learning when participants performed the F-MP and facilitated learning for the S-MP. MEPs data paralleled behavioral results, confirming that the effects generated by A-tDCS depend on the excitability changes induced by the task. CONCLUSIONS: Our results demonstrate that tDCS-induced plasticity is task-dependent, and the concurrent combination of A-tDCS with another excitability-increasing event, e.g., motor practice, may trigger non-additive mechanisms, hindering neuroplasticity.
The interaction with task-induced activity is more important than polarization: a tDCS study / Bortoletto, M; Pellicciari, Mc; Rodella, C; Miniussi, Carlo. - In: BRAIN STIMULATION. - ISSN 1935-861X. - 2015, 8:2(2015), pp. 269-276.
|Titolo:||The interaction with task-induced activity is more important than polarization: a tDCS study|
|Autori:||Bortoletto, M; Pellicciari, Mc; Rodella, C; Miniussi, Carlo|
|Titolo del periodico:||BRAIN STIMULATION|
|Anno di pubblicazione:||2015|
|Numero e parte del fascicolo:||2|
|Codice identificativo Scopus:||2-s2.0-84922942486|
|Codice identificativo Pubmed:||25464828|
|Codice identificativo ISI:||WOS:000348856800014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.brs.2014.11.006|
|Citazione:||The interaction with task-induced activity is more important than polarization: a tDCS study / Bortoletto, M; Pellicciari, Mc; Rodella, C; Miniussi, Carlo. - In: BRAIN STIMULATION. - ISSN 1935-861X. - 2015, 8:2(2015), pp. 269-276.|
|Appare nelle tipologie:||03.1 Articolo su rivista (Journal article)|
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