The PC3 gene is a marker of dividing neuroepithelial (NE) cells. We transduced single cortical precursors of the ventricular zone (VZ) with a PC3-carrying retroviral vector at E16 stage, and analysed the effects of transgene expression on their progeny in 3-week-old animals. Unlike control-transduced cells, all viable PC3-transduced cells remained close to the ventricle and displayed a round-shaped, undifferentiated morphology.

In vivo PC3 overexpression by retroviral vector affects cell differentiation of rat cortical precursors

Sgadò, Paola;
2001-01-01

Abstract

The PC3 gene is a marker of dividing neuroepithelial (NE) cells. We transduced single cortical precursors of the ventricular zone (VZ) with a PC3-carrying retroviral vector at E16 stage, and analysed the effects of transgene expression on their progeny in 3-week-old animals. Unlike control-transduced cells, all viable PC3-transduced cells remained close to the ventricle and displayed a round-shaped, undifferentiated morphology.
2001
2
Malatesta, P; Sgadò, Paola; Caneparo, L; Barsacchi, G; Cremisi, F.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/126091
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