In the nematode Caenorhabditis elegans, the let-7 microRNA (miRNA) controls the timing of key developmental events and terminal differentiation in part by directly regulating lin-41. C. elegans lin-41 mutants display precocious cell cycle exit and terminal differentiation of epidermal skin cells. lin-41 orthologues are found in more complex organisms including both mice and humans, but their roles are not known. We generated Mlin41 mouse mutants to ascertain a functional role for Mlin41. Strong loss of function Mlin41 gene-trap mutants demonstrated a striking neural tube closure defect during development, and embryonic lethality. Like C. elegans lin-41, Mlin41 also appears to be regulated by the let-7 and mir-125 miRNAs. Since Mlin41 is required for neural tube closure and survival it points to human lin-41 (HLIN41/TRIM71) as a potential human development and disease gene.

The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure / Maller Schulman, Betsy R; Liang, Xianping; Stahlhut, Carlos; Delconte, Casey; Stefani, Giovanni; Slack, Frank J.. - In: CELL CYCLE. - ISSN 1551-4005. - 7:24(2008), pp. 3935-3942. [10.4161/cc.7.24.7397]

The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure

Stefani, Giovanni;
2008

Abstract

In the nematode Caenorhabditis elegans, the let-7 microRNA (miRNA) controls the timing of key developmental events and terminal differentiation in part by directly regulating lin-41. C. elegans lin-41 mutants display precocious cell cycle exit and terminal differentiation of epidermal skin cells. lin-41 orthologues are found in more complex organisms including both mice and humans, but their roles are not known. We generated Mlin41 mouse mutants to ascertain a functional role for Mlin41. Strong loss of function Mlin41 gene-trap mutants demonstrated a striking neural tube closure defect during development, and embryonic lethality. Like C. elegans lin-41, Mlin41 also appears to be regulated by the let-7 and mir-125 miRNAs. Since Mlin41 is required for neural tube closure and survival it points to human lin-41 (HLIN41/TRIM71) as a potential human development and disease gene.
24
Maller Schulman, Betsy R; Liang, Xianping; Stahlhut, Carlos; Delconte, Casey; Stefani, Giovanni; Slack, Frank J.
The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure / Maller Schulman, Betsy R; Liang, Xianping; Stahlhut, Carlos; Delconte, Casey; Stefani, Giovanni; Slack, Frank J.. - In: CELL CYCLE. - ISSN 1551-4005. - 7:24(2008), pp. 3935-3942. [10.4161/cc.7.24.7397]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11572/123636
Citazioni
  • ???jsp.display-item.citation.pmc??? 55
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact