Silks, and in particular silks from silkworms cocoons, have been used for many years as suture filaments, more recently acquiring novel attention for other applications in medicine and namely in tissue en- gineering. The ‘‘silks success’’ should be attributed to the material versatile properties that can be tuned according to the requirements via tailored processing and post-treatment methods that, in turn, affect molecular structure, supramolecular conformation and final properties. By adjusting biopolymer architecture and chemical composition, the formation of the extra cellular matrix (ECM) can be triggered such as to guide cells to the generation of functional tissues. Crystallinity and morphologies at different scale level can induce different blood responses in terms of platelet adhesion and activation, modulate the interaction with the inflammatory system, and control the stem cell fate. Materials source, advanced processing strategies and selective chemical modifications can control chemistry and thus silk’s function. Silk fibroin can be used as polymer model to debate the relationship between material structure, physical and biological properties. The lecture will explore the history, uses and potential future of silk fibroin as elective materials for tissue engineering applications, starting from basic ‘‘primitive’’ bidimensional substrates till the design and fabrication of microniches populated 3D structures able to guide the cell behavior and the regenerative process.
Silk: from textiles to tissue regeneration / Motta, Antonella; Migliaresi, Claudio. - In: TISSUE ENGINEERING, PART A. - ISSN 1937-3341. - ELETTRONICO. - :Volume 21, supplement 1, 2015(2015), pp. 35-36. ((Intervento presentato al convegno TERMIS 2015 World Congress tenutosi a Boston nel 8th-11th september 2015.
|Titolo:||Silk: from textiles to tissue regeneration|
|Autori:||Motta, Antonella; Migliaresi, Claudio|
|Titolo del volume contenente il saggio:||2015 TERMIS World Congress: PAST, PRESENT, FUTURE The Evolution of Regenerative Medicine|
|Luogo di edizione:||USA|
|Casa editrice:||Mary Ann Liebert Inc.|
|Anno di pubblicazione:||2015|
|Citazione:||Silk: from textiles to tissue regeneration / Motta, Antonella; Migliaresi, Claudio. - In: TISSUE ENGINEERING, PART A. - ISSN 1937-3341. - ELETTRONICO. - :Volume 21, supplement 1, 2015(2015), pp. 35-36. ((Intervento presentato al convegno TERMIS 2015 World Congress tenutosi a Boston nel 8th-11th september 2015.|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1089/ten.tea.2015.5000.abstracts.|
|Appare nelle tipologie:||04.2 Abstract in atti di convegno (Abstract in Proceedings)|