Silks, and in particular silks from silkworms cocoons, have been used for many years as suture filaments, more recently acquiring novel attention for other applications in medicine and namely in tissue en- gineering. The ‘‘silks success’’ should be attributed to the material versatile properties that can be tuned according to the requirements via tailored processing and post-treatment methods that, in turn, affect molecular structure, supramolecular conformation and final properties. By adjusting biopolymer architecture and chemical composition, the formation of the extra cellular matrix (ECM) can be triggered such as to guide cells to the generation of functional tissues. Crystallinity and morphologies at different scale level can induce different blood responses in terms of platelet adhesion and activation, modulate the interaction with the inflammatory system, and control the stem cell fate. Materials source, advanced processing strategies and selective chemical modifications can control chemistry and thus silk’s function. Silk fibroin can be used as polymer model to debate the relationship between material structure, physical and biological properties. The lecture will explore the history, uses and potential future of silk fibroin as elective materials for tissue engineering applications, starting from basic ‘‘primitive’’ bidimensional substrates till the design and fabrication of microniches populated 3D structures able to guide the cell behavior and the regenerative process.

Silk: from textiles to tissue regeneration / Motta, Antonella; Migliaresi, Claudio. - In: TISSUE ENGINEERING, PART A. - ISSN 1937-3341. - ELETTRONICO. - Volume 21, supplement 1, 2015(2015), pp. 35-36. ((Intervento presentato al convegno TERMIS 2015 World Congress tenutosi a Boston nel 8th-11th september 2015 [10.1089/ten.tea.2015.5000.abstracts.].

Silk: from textiles to tissue regeneration

Motta, Antonella;Migliaresi, Claudio
2015

Abstract

Silks, and in particular silks from silkworms cocoons, have been used for many years as suture filaments, more recently acquiring novel attention for other applications in medicine and namely in tissue en- gineering. The ‘‘silks success’’ should be attributed to the material versatile properties that can be tuned according to the requirements via tailored processing and post-treatment methods that, in turn, affect molecular structure, supramolecular conformation and final properties. By adjusting biopolymer architecture and chemical composition, the formation of the extra cellular matrix (ECM) can be triggered such as to guide cells to the generation of functional tissues. Crystallinity and morphologies at different scale level can induce different blood responses in terms of platelet adhesion and activation, modulate the interaction with the inflammatory system, and control the stem cell fate. Materials source, advanced processing strategies and selective chemical modifications can control chemistry and thus silk’s function. Silk fibroin can be used as polymer model to debate the relationship between material structure, physical and biological properties. The lecture will explore the history, uses and potential future of silk fibroin as elective materials for tissue engineering applications, starting from basic ‘‘primitive’’ bidimensional substrates till the design and fabrication of microniches populated 3D structures able to guide the cell behavior and the regenerative process.
2015 TERMIS World Congress: PAST, PRESENT, FUTURE The Evolution of Regenerative Medicine
USA
Mary Ann Liebert Inc.
Silk: from textiles to tissue regeneration / Motta, Antonella; Migliaresi, Claudio. - In: TISSUE ENGINEERING, PART A. - ISSN 1937-3341. - ELETTRONICO. - Volume 21, supplement 1, 2015(2015), pp. 35-36. ((Intervento presentato al convegno TERMIS 2015 World Congress tenutosi a Boston nel 8th-11th september 2015 [10.1089/ten.tea.2015.5000.abstracts.].
Motta, Antonella; Migliaresi, Claudio
File in questo prodotto:
File Dimensione Formato  
Silk from textiles to tissue regeneration .pdf

accesso aperto

Descrizione: Abstract
Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 74.87 kB
Formato Adobe PDF
74.87 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11572/115594
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact